Effects of Perinatal Hypoxia on Serum Unbound Free Fatty Acids and Lung Inflammatory Mediators

Neonatology ◽  
2001 ◽  
Vol 79 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Barry Weinberger ◽  
Tracy Carbone ◽  
Sandra England ◽  
Alan M. Kleinfeld ◽  
Mark Hiatt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Inflammatory Mediators ◽  
Perinatal Hypoxia ◽  
Unbound Free Fatty Acids

scholarly journals The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

2008 ◽  
Vol 54 (6) ◽  
pp. 945-955 ◽  
Author(s):  
Sarah de Ferranti ◽  
Dariush Mozaffarian
Keyword(s):  
Fatty Acids ◽  
Endoplasmic Reticulum ◽  
Free Fatty Acids ◽  
Health Effects ◽  
Inflammatory Mediators ◽  
Laboratory Evaluation ◽  
Energy Imbalance ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
Adipocyte Hypertrophy

Abstract Background: As the prevalence of adiposity soars in both developed and developing nations, appreciation of the close links between obesity and disease increases. The strong relationships between excess adipose tissue and poor health outcomes, including cardiovascular disease, diabetes, and cancer, mandate elucidation of the complex cellular, hormonal, and molecular pathophysiology whereby adiposity initiates and maintains adverse health effects. Content: In this report we review adipocyte metabolism and function in the context of energy imbalance and postprandial nutrient excess, including adipocyte hypertrophy and hyperplasia, adipocyte dysfunction, and other systemic consequences. We also discuss implications for laboratory evaluation and clinical care, including the role of lifestyle modifications. Chronic energy imbalance produces adipocyte hypertrophy and hyperplasia, endoplasmic reticulum stress, and mitochondrial dysfunction. These processes lead to increased intracellular and systemic release of adipokines, free fatty acids, and inflammatory mediators that cause adipocyte dysfunction and induce adverse effects in the liver, pancreatic β-cells, and skeletal muscle as well as the heart and vascular beds. Several specialized laboratory tests can quantify these processes and predict clinical risk, but translation to the clinical setting is premature. Current and future pharmacologic interventions may target these pathways; modest changes in diet, physical activity, weight, and smoking are likely to have the greatest impact. Summary: Adipocyte endoplasmic reticulum and mitochondrial stress, and associated changes in circulating adipokines, free fatty acids, and inflammatory mediators, are central to adverse health effects of adiposity. Future investigation should focus on these pathways and on reversing the adverse lifestyle behaviors that are the fundamental causes of adiposity.

scholarly journals Fatty Acid-Specific Fluorescent Probes and Their Use in Resolving Mixtures of Unbound Free Fatty Acids in Equilibrium with Albumin†

Biochemistry ◽  
2006 ◽  
Vol 45 (48) ◽  
pp. 14263-14274 ◽  
Author(s):  
Andrew H. Huber ◽  
J. Patrick Kampf ◽  
Thomas Kwan ◽  
Baolong Zhu ◽  
Alan M. Kleinfeld
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Fluorescent Probes ◽  
Unbound Free Fatty Acids

scholarly journals Effects of Soybean Lipid Infusion on Unbound Free Fatty Acids and Unbound Bilirubin in Preterm Infants

2017 ◽  
Vol 184 ◽  
pp. 45-50.e1 ◽  
Author(s):  
Thomas Hegyi ◽  
Alan Kleinfeld ◽  
Andrew Huber ◽  
Barry Weinberger ◽  
Naureen Memon ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Preterm Infants ◽  
Lipid Infusion ◽  
Unbound Bilirubin ◽  
Unbound Free Fatty Acids

Serum levels of unbound free fatty acids. I: Normative data in term newborn infants.

1997 ◽  
Vol 16 (1) ◽  
pp. 81-84 ◽  
Author(s):  
M N Patel ◽  
A M Kleinfeld ◽  
G V Richeiri ◽  
S Ruben ◽  
M Hiatt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Normative Data ◽  
Newborn Infants ◽  
Serum Levels ◽  
Term Newborn ◽  
Unbound Free Fatty Acids

Unbound Free Fatty Acids from Preterm Infants Treated with Intralipid Decouples Unbound from Total Bilirubin Potentially Making Phototherapy Ineffective

Neonatology ◽  
2013 ◽  
Vol 104 (3) ◽  
pp. 184-187 ◽  
Author(s):  
Thomas Hegyi ◽  
Suganya Kathiravan ◽  
Gary E. Stahl ◽  
Andrew H. Huber ◽  
Alan Kleinfeld
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Preterm Infants ◽  
Total Bilirubin ◽  
Unbound Free Fatty Acids
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