The Inner Hair Cell Synaptic Complex: Physiology, Pharmacology and New Therapeutic Strategies

2002 ◽  
Vol 7 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Jean-Luc Puel ◽  
Jérôme Ruel ◽  
Matthieu Guitton ◽  
Jing Wang ◽  
Rémy Pujol
Keyword(s):  
Hair Cell ◽  
Therapeutic Strategies ◽  
Inner Hair Cell ◽  
Synaptic Complex

Physiology, pharmacology and plasticity at the inner hair cell synaptic complex

2007 ◽  
Vol 227 (1-2) ◽  
pp. 19-27 ◽  
Author(s):  
Jérôme Ruel ◽  
Jing Wang ◽  
Guy Rebillard ◽  
Michel Eybalin ◽  
Ruth Lloyd ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Hair Cell ◽  
Synaptic Complex

scholarly journals Inner hair cell stereocilia are embedded in the tectorial membrane

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pierre Hakizimana ◽  
Anders Fridberger
Keyword(s):  
Electron Microscopy ◽  
Hair Cell ◽  
Mechanical Stimulation ◽  
Hair Cells ◽  
Viscous Drag ◽  
Tectorial Membrane ◽  
Inner Hair Cell ◽  
Inner Hair Cells ◽  
Inward Currents

AbstractMammalian hearing depends on sound-evoked displacements of the stereocilia of inner hair cells (IHCs), which cause the endogenous mechanoelectrical transducer channels to conduct inward currents of cations including Ca2+. Due to their presumed lack of contacts with the overlaying tectorial membrane (TM), the putative stimulation mechanism for these stereocilia is by means of the viscous drag of the surrounding endolymph. However, despite numerous efforts to characterize the TM by electron microscopy and other techniques, the exact IHC stereocilia-TM relationship remains elusive. Here we show that Ca2+-rich filamentous structures, that we call Ca2+ ducts, connect the TM to the IHC stereocilia to enable mechanical stimulation by the TM while also ensuring the stereocilia access to TM Ca2+. Our results call for a reassessment of the stimulation mechanism for the IHC stereocilia and the TM role in hearing.

Free radical scavenger protects against inner hair cell loss after cochlear ischemia

Neuroreport ◽  
2003 ◽  
Vol 14 (14) ◽  
pp. 1881-1884 ◽  
Author(s):  
Toshiki Maetani ◽  
Nobuhiro Hakuba ◽  
Masafumi Taniguchi ◽  
Jun Hyodo ◽  
Yoshitaka Shimizu ◽  
...  
Keyword(s):  
Free Radical ◽  
Hair Cell ◽  
Cell Loss ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Hair Cell Loss ◽  
Inner Hair Cell

scholarly journals A Complex of RIM2alpha and RIM-Binding Protein 2 Stabilizes Slow Voltage-Dependent Inactivation of Cochlear Inner Hair Cell Cav1.3 L-Type Ca2+ Channels

2018 ◽  
Vol 114 (3) ◽  
pp. 637a-638a
Author(s):  
Nadine J. Ortner ◽  
Alexandra Pinggera ◽  
Anita Siller ◽  
Nadja Hofer ◽  
Niels Brandt ◽  
...  
Keyword(s):  
Hair Cell ◽  
Binding Protein ◽  
Inner Hair Cell ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Ca2 Channels

scholarly journals THE ULTRASTRUCTURE OF THE SENSORY HAIRS AND ASSOCIATED ORGANELLES OF THE COCHLEAR INNER HAIR CELL, WITH REFERENCE TO DIRECTIONAL SENSITIVITY

1966 ◽  
Vol 29 (3) ◽  
pp. 497-505 ◽  
Author(s):  
Arndt J. Duvall ◽  
Åke Flock ◽  
Jan Wersäll
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Basal Body ◽  
Organ Of Corti ◽  
Sensory Cells ◽  
Directional Sensitivity ◽  
Inner Hair Cell ◽  
Lateral Line Organ ◽  
Sensory Hairs ◽  
Line Organ

From the apical end of the inner hair cell of the organ of Corti in the guinea pig cochlea protrude four to five rows of stereocilia shaped in a pattern not unlike the wings of a bird. In the area devoid of cuticular substance facing toward the tunnel of Corti lies a consistently present centriole. The ultrastructure of this centriole is similar to that of the basal body of the kinocilium located in the periphery of the sensory hair bundles in the vestibular and lateral line organ sensory cells and to that of the centrioles of other cells. The physiological implications of the anatomical orientation of this centriole are discussed in terms of directional sensitivity.

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