Are Uraemic Children Immunologically Compromised?

Nephron ◽  
2001 ◽  
Vol 88 (4) ◽  
pp. 379-381 ◽  
Author(s):  
Cüneyt Ensari ◽  
Mesiha Ekim ◽  
Aydan Ikinciogullari ◽  
Necmiye Tümer ◽  
Arzu Ensari
Keyword(s):  
Uraemic Children

Growth hormone response to growth hormone-releasing hormone in normal and uraemic children. Comparison with hypoglycaemia following insulin administration

1987 ◽  
Vol 114 (1) ◽  
pp. 5-11 ◽  
Author(s):  
D. Bessarione ◽  
F. Perfumo ◽  
M. Giusti ◽  
F. Ginevri ◽  
G. Mazzocchi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Adverse Effects ◽  
Significant Variation ◽  
Growth Hormone Releasing Hormone ◽  
Blood Samples ◽  
Releasing Hormone ◽  
Uraemic Children ◽  
Insulin Test ◽  
Peak Value

Abstract. The uraemic syndrome is characterized by several endocrinological disturbances. This study was undertaken in order to evaluate the GH response to growth hormone-releasing hormone (GRH) in children with chronic renal failure (CRF) and to compare the results with those observed after insulin hypoglycaemia. Twenty-two children with CRF, 10 undergoing continuous ambulatory peritoneal dialysis (CAPD) and 12 on conservative treatment (CT), age ranges 2–15 years, were studied and the data were compared with those from 14 children with normal renal function and normal hormonal behaviour, affected by short stature (NC), and those form 13 healthy adult volunteers (NA). The GRH test (1 μg/kg body weight, iv) was carried out in 8 CAPD, 8 CT, 9 NC and 10 NA subjects. The blood samples were taken every 30 min for 3 h in CAPD and CT and for 2 h in NC and NA starting at 09.00 h. The following hormones were measured: GH, LH, FSH, Prl, TSH and cortisol (F). The insulin test (0.1 U/kg body weight, iv) was carried out in 5 CAPD, 5 CT, 10 NC and 9 NA on blood samples taken every 30 min for 2 h, measuring GH and glycaemia. No adverse effects were observed after the infusion of GRH. GRH administration induced a prompt response in all subjects, but GH plasma levels were significantly higher in uraemic children than in adults (peak value of 43.5 ± 8.2, 45.0 ± 8.4, 27.8 ± 6.0; 13.5 ± 2.6 μg/ml in CAPD, CT, NC and NA, respectively). The secretory areas were significantly narrower in NC (P < 0.05) and NA (P < 0.01) than in CAPD, and in NA than in CT (P < 0.01). The GH response to insulin did not differ in the 4 groups. The secretory area in CAPD and CT was wider after GRH than after insulin. The GH peak value of CAPD and NC was significantly higher after GRH than following insulin. No significant variation in TSH, LH and FSH was observed after the infusion of the neuropeptide, whereas Prl and F showed a reduction. The behaviour of Prl and F in NA and NC was similar after placebo and GRH. Our data show: a) There is a greater response of GH to GRH in children than in adults; b) compared with the insulin test, GRH stimulation seems to be a reliable means of evaluating GH secretion both in normal and uraemic children owing to the absence of qualitatively different responses and to the freedom from the adverse effects or risks which follow insulin infusion; c) GRH administration does not induce any significant variation on other hypophyseal hormones and the reduction of Prl and F seems to follow the normal sleep-wake and circadian behaviour.

The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy

1989 ◽  
Vol 3 (3) ◽  
pp. 305-308 ◽  
Author(s):  
Raphael Drachman ◽  
Menahem Schlesinger ◽  
Hava Shapira ◽  
Alfred Drukker
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Immune Status ◽  
Uraemic Children

On the Inhibitory Effect of the Serum of Uraemic Children on Erythropoiesis

1980 ◽  
Vol 64 (5) ◽  
pp. 256-264 ◽  
Author(s):  
P. Scigalla ◽  
V.I. Gudim ◽  
V.S. Ivanova ◽  
N.A. Fedorov ◽  
P. Grossmann
Keyword(s):  
Inhibitory Effect ◽  
Uraemic Children

Critical care in uraemic children

1992 ◽  
Vol 6 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Jekabs U. Leititis ◽  
Matthias Brandis
Keyword(s):  
Critical Care ◽  
Uraemic Children

8 Renal osteodystrophy in uraemic children

1980 ◽  
Vol 9 (1) ◽  
pp. 151-176 ◽  
Author(s):  
Otto Mehls ◽  
Eberhard Ritz ◽  
Wilhelm Kreusser ◽  
Burkhard Krempien
Keyword(s):  
Renal Osteodystrophy ◽  
Uraemic Children

scholarly journals Free amino acids in plasma, red blood cells, polymorphonuclear leukocytes, and muscle in normal and uraemic children

2002 ◽  
Vol 17 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Alberto Canepa ◽  
José Carolino Divino Filho ◽  
Alberto Gutierrez ◽  
Alba Carrea ◽  
Ann‐Marie Forsberg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Free Amino Acids ◽  
Free Amino ◽  
Polymorphonuclear Leukocytes ◽  
Uraemic Children

scholarly journals Plasma thrombomodulin concentrations in uraemic children

1996 ◽  
Vol 11 (11) ◽  
pp. 2369-2370
Author(s):  
S. Ozdemir ◽  
N. Besbas ◽  
u. Saatci ◽  
A. Bakkalo lu
Keyword(s):  
Uraemic Children
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