Transforming Growth Factor-β1 Inhibits Vascular Permeability Factor Release by T Cells in Normal Subjects and in Patients with Minimal-Change Nephrotic Syndrome

Nephron ◽  
2001 ◽  
Vol 87 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Koichi Matsumoto ◽  
Katsuo Kanmatsuse
Keyword(s):  
T Cells ◽  
Nephrotic Syndrome ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Normal Subjects ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Vascular Permeability Factor ◽  
Factor Release

Leptin, soluble leptin receptor, and transforming growth factor-?1 levels in minimal change nephrotic syndrome

2003 ◽  
Vol 18 (10) ◽  
pp. 1009-1014 ◽  
Author(s):  
Necla Buyan ◽  
Ozan �zkaya ◽  
Aysun Bideci ◽  
Oguz S�ylemezoglu ◽  
Peyami Cinaz ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Growth Factor ◽  
Leptin Receptor ◽  
Transforming Growth Factor ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Soluble Leptin Receptor

Effect of ELAD Liver Support on Plasma HGF and TGF–β1 in Acute Liver Failure

1996 ◽  
Vol 19 (4) ◽  
pp. 240-244 ◽  
Author(s):  
Y. Miwa ◽  
A.J. Ellis ◽  
R.D. Hughes ◽  
P.G. Langley ◽  
J.A. Wendon ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Normal Subjects ◽  
Heparin Binding ◽  
Liver Support ◽  
Subsequent Decrease ◽  
Initial Plasma

The aim of this study was to investigate the effects of treatment with the extracorporeal liver assist device (ELAD) in patients with acute liver failure (ALF) on plasma hepatocyte growth factor (HGF), the most potent growth factor, and transforming growth factor-β1 (TGF-β1), an inhibitory factor for liver regeneration. Initial plasma HGF, measured by ELISA, was significantly increased in the ALF patients (7.86 ± SEM 1.76 ng/ml) compared with normal subjects (0.10 ± 0.02 ng/ml, p<0.001). After 6 hours of ELAD haemoperfusion, plasma HGF increased further (30.5 ± 6.19 ng/ml, p<0.001), with a subsequent decrease towards the initial value by 48 hours. Initial plasma levels of TGF-β1 determined by ELISA were significantly increased in the ALF patients (43.4 ± 5.9 ng/ml) compared with normal subjects (25.1 ± 2.3 ng/ml, p<0.01), but there was no change in plasma TGF-β1 during the study period in either the ELAD or control ALF group. As HGF is a heparin-binding growth factor and similar changes in HGF were observed during CVVHD, one possible explanation is that heparin administered as anticoagulant for extracorporeal circulation is involved in the effects observed on HGF.

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