Cytokine Gene Expression in Adriamycin Nephropathy: Effects of Antioxidant Nuclear Factor κB Inhibitors in Established Disease

Nephron ◽  
2000 ◽  
Vol 86 (4) ◽  
pp. 482-490 ◽  
Author(s):  
Gopala K. Rangan ◽  
Yiping Wang ◽  
Yuet-Ching Tay ◽  
David C.H. Harris
Keyword(s):  
Gene Expression ◽  
Nuclear Factor Κb ◽  
Cytokine Gene Expression ◽  
Nuclear Factor ◽  
Cytokine Gene ◽  
Adriamycin Nephropathy ◽  
Established Disease

Thyroid hormone-induced oxidative stress triggers nuclear factor-κB activation and cytokine gene expression in rat liver

2003 ◽  
Vol 35 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Gladys Tapia ◽  
Virginia Fernández ◽  
Patricia Varela ◽  
Pamela Cornejo ◽  
Julia Guerrero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Thyroid Hormone ◽  
Rat Liver ◽  
Nuclear Factor Κb ◽  
Cytokine Gene Expression ◽  
Nuclear Factor ◽  
Cytokine Gene

scholarly journals Nfat

2002 ◽  
Vol 156 (5) ◽  
pp. 771-774 ◽  
Author(s):  
Valerie Horsley ◽  
Grace K. Pavlath
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Transcription Factors ◽  
Immune System ◽  
Cell Types ◽  
Cytokine Gene Expression ◽  
Nuclear Factor ◽  
Cytokine Gene ◽  
Activated T Cells ◽  
Control Of Gene Expression

The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.

scholarly journals TLR4 overexpression enhances saturated fatty acid–induced inflammatory cytokine gene expression in sheep

2018 ◽  
Vol 16 ◽  
pp. 205873921879297 ◽  
Author(s):  
Xue Xu ◽  
Mei-Yu Qi ◽  
Shuang Liu ◽  
Xu-Ting Song ◽  
Jia-Nan Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Inflammatory Cytokine ◽  
Saturated Fatty Acids ◽  
Nuclear Factor Κb ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Factor Α

Saturated fatty acids (SFAs) can directly stimulate innate immune responses, thereby exacerbating inflammatory aspects of metabolic syndrome. Dietary SFAs act as ligands of Toll-like receptor 4 (TLR4), triggering associated signaling pathways. In this study, we investigated the role of TLR4 in palm oil SFA-associated inflammatory cytokine gene expression in monocytes/macrophages and adipose tissue using TLR4-overexpressing genetically modified sheep. SFA stimulation resulted in upregulation of interleukin-6 ( IL-6), tumor necrosis factor-α ( TNF-α), interleukin-8 ( IL-8), interferon-γ ( IFN-γ), and interleukin-10 ( IL-10), and TLR4 overexpression enhanced such SFA-induced inflammatory cytokine expression. Moreover, SFAs markedly activated MyD88-dependent signaling, including IL-1 receptor–associated kinase 4 ( IRAK4), TNF receptor–associated factor 6 ( TRAF6), and nuclear factor-κB ( NF-κB). Taken together, our results indicate that TLR4 overexpression enhances the SFA-induced inflammatory response through MyD88-dependent signaling in monocytes/macrophages and adipose tissue.

Nuclear Factor-Kappa B Activation in the Nasal Polyp Epithelium: Relationship to Local Cytokine Gene Expression

2002 ◽  
Vol 112 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Sachio Takeno ◽  
Katsuhiro Hirakawa ◽  
Tsutomu Ueda ◽  
Kyosuke Furukido ◽  
Rika Osada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nasal Polyp ◽  
Nuclear Factor Kappa B ◽  
Cytokine Gene Expression ◽  
Nuclear Factor ◽  
Cytokine Gene ◽  
Nuclear Factor Kappa ◽  
Local Cytokine
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