Adrenomedullin Gene Transcription Is Decreased in Peripheral Blood Mononuclear Cells of Patients with IgA Nephropathy

Nephron ◽  
2000 ◽  
Vol 85 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Atsushi Kubo ◽  
Yoshiharu Nishitani ◽  
Naoto Minamino ◽  
Katsuro Kikumoto ◽  
Hideyuki Kurioka ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Gene Transcription ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers

2005 ◽  
Vol 22 (3) ◽  
pp. 402-411 ◽  
Author(s):  
John J. Eady ◽  
Gary M. Wortley ◽  
Yvette M. Wormstone ◽  
Jackie C. Hughes ◽  
Siân B. Astley ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Interindividual Variation ◽  
Human Tissues ◽  
Healthy Human ◽  
Peripheral Blood Mononuclear ◽  
Transcription Profiles ◽  
Blood Mononuclear Cells

The normal degree of intra- and interindividual variation in gene transcription profiles of healthy human tissues has not been extensively investigated. In the study described here, microarrays were employed to analyze gene transcription in peripheral blood mononuclear cells prepared from serial blood samples that had been obtained, at weekly intervals, from apparently healthy human volunteers. Transcript levels for the majority of genes examined were found to be remarkably consistent within samples from a single donor. Conversely, marked differences were observed in samples obtained from different donors. Genes that exhibited differential expression dependent on sex, age, body mass index, and the presence of varying proportions of different leukocyte subsets were identified. These results emphasize the important contributions of genetic and environmental factors, as well as varying representation of different cell types, in determining the overall gene transcriptional profiles of human tissues. However, the study also provides evidence that, within an individual, the gene transcription profiles of sampled tissues can be comparatively stable over time.

scholarly journals Proto-oncogene expression in peripheral blood mononuclear cells in IgA nephropathy

1991 ◽  
Vol 39 (5) ◽  
pp. 946-953 ◽  
Author(s):  
Isao Ebihara ◽  
Tsukasa Nakamura ◽  
Shigenobu Suzuki ◽  
Yasuhiko Tomino ◽  
Hikaru Koide
Keyword(s):  
Iga Nephropathy ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Oncogene Expression ◽  
Blood Mononuclear Cells

scholarly journals Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy

2009 ◽  
Vol 75 (5) ◽  
pp. 536-541 ◽  
Author(s):  
Rosanna Coppo ◽  
Roberta Camilla ◽  
Alda Alfarano ◽  
Sabrina Balegno ◽  
Domenico Mancuso ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells
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