Focal Segmental Glomerulosclerosis in a 32-Year-Old Kidney Allograft after7 Years without Immunosuppression

Nephron ◽  
1999 ◽  
Vol 82 (3) ◽  
pp. 270-273 ◽  
Author(s):  
Hernan M. Trimarchi ◽  
Juan M. Gonzalez ◽  
Luan D. Truong ◽  
T. Stephen Brennan ◽  
Roberto Barrios ◽  
...  
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Kidney Allograft ◽  
Segmental Glomerulosclerosis

Plasmapheresis for Prevention of Recurrent Focal Segmental Glomerulosclerosis of Kidney Allograft in Adult Recipients

1997 ◽  
Vol 1 (2) ◽  
pp. 191-194 ◽  
Author(s):  
Yasuhiro Iguchi ◽  
Kazunari Tanabe ◽  
Takashi Yagisawa ◽  
Syohei Fuchinoue ◽  
Tatsuro Kawai ◽  
...  
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Kidney Allograft ◽  
Segmental Glomerulosclerosis

scholarly journals A Specific Tubular ApoA-I Distribution Is Associated to FSGS Recurrence after Kidney Transplantation

2021 ◽  
Vol 10 (10) ◽  
pp. 2174
Author(s):  
Conxita Jacobs-Cachá ◽  
Natàlia Puig-Gay ◽  
Ander Vergara ◽  
Maria-Alejandra Gabaldon ◽  
Joana Sellarés ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Brush Border ◽  
Diagnostic Tool ◽  
Apical Membrane ◽  
Major Complication ◽  
Kidney Allograft ◽  
Tubular Cells ◽  
Apolipoprotein A ◽  
Segmental Glomerulosclerosis

A major complication of primary focal segmental glomerulosclerosis (FSGS) is its recurrence after kidney transplantation that happens in 30 to 40% of the patients. The diagnosis of these relapses is not always easy as the histological lesions are not highly specific and appear after the proteinuria increase. Currently, there are no accurate biomarkers to detect FSGS recurrence. Our group identified a modified form of Apolipoprotein A-I (ApoA-I), named ApoA-Ib, specifically present in the urine of recurrent FSGS patients after kidney transplantation. Aberrant forms of ApoA-I have also been described in the urine of native primary FSGS patients; this feature has been associated with prominent staining of ApoA-I at the apical membrane of the tubular cells. In this study, we aim to analyze the ApoA-I distribution in kidney allograft biopsies of recurrent FSGS patients. We detected ApoA-I by immunohistochemistry in kidney allograft biopsies of patients with FSGS relapse after kidney transplantation and in kidney allograft biopsies of patients with a disease different from FSGS in the native kidney (non-FSGS). In recurrent FSGS patients, ApoA-I was prominently localized at the brush border of the tubular cells, while in the non-FSGS patients, ApoA-I was found along the cytoplasm of the tubular cells. The localization of ApoA-I at the brush border of the tubular cells is a specific feature of primary FSGS in relapse. This suggests that ApoA-I staining in kidney biopsies, coupled with ApoA-Ib measurement in urine, could be used as a diagnostic tool of primary FSGS relapse after kidney transplantation due to its highly specific tubular distribution.

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