The Serum Paraoxonase Activity in Patients with Chronic Renal Failure and Hyperlipidemia

Nephron ◽  
1998 ◽  
Vol 80 (2) ◽  
pp. 166-170 ◽  
Author(s):  
György Paragh ◽  
Ildikó Seres ◽  
Zoltán Balogh ◽  
Zsuzsa Varga ◽  
István Kárpáti ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity ◽  
Serum Paraoxonase

Serum Paraoxonase Activity and Protein Thiols in Chronic Renal Failure Patients

2007 ◽  
Vol 2 (4) ◽  
pp. 274-278 ◽  
Author(s):  
Jeevan K. Shetty . ◽  
Mungli Prakash . ◽  
Sudeshna Tripathy . ◽  
Manish Verma . ◽  
Nagaraj K. Shashidha . ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity ◽  
Protein Thiols ◽  
Serum Paraoxonase

scholarly journals Decrease of serum paraoxonase activity in chronic renal failure.

1998 ◽  
Vol 9 (11) ◽  
pp. 2082-2088
Author(s):  
T F Dantoine ◽  
J Debord ◽  
J P Charmes ◽  
L Merle ◽  
P Marquet ◽  
...  
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Chronic Hemodialysis ◽  
Phenyl Acetate ◽  
Paraoxonase Activity ◽  
Control Subjects ◽  
Transplant Patients ◽  
End Stage ◽  
Serum Paraoxonase

Paraoxonase is an esterase that hydrolyzes organophosphate compounds. The enzyme is associated with HDL and could protect LDL against peroxidation, which suggests a possible involvement of paraoxonase in the antiatherogenic properties of HDL. Paraoxonase activity has been shown to be low in patients with myocardial infarction, diabetes mellitus, or familial hypercholesterolemia. Because cardiovascular disease is the main cause of death in chronic renal failure, serum paraoxonase activity was measured by spectrophotometry using three synthetic substrates (phenyl acetate, paraoxon, and 4-nitrophenyl acetate) in 305 patients with kidney disease, including 47 patients with non-end-stage chronic renal failure, 104 patients treated with hemodialysis, 22 patients treated with peritoneal dialysis, and 132 renal transplant patients. Patients were compared with two groups of aged-matched control subjects (total number = 195). Especially with 4-nitrophenyl acetate, paraoxonase activity was lower in patients with some degree of renal insufficiency (chronic renal failure [P < 0.05], chronic hemodialysis [P < 10(-4)], chronic peritoneal dialysis [P < 10(-4)]) than in control subjects. In transplant patients, paraoxonase activity was not found to be different from that in control subjects. The decrease of paraoxonase activity and thus the reduction of its antiatherogenic properties in renal failure could be an essential factor of premature vascular aging, especially when dialysis is used. Renal transplantation seems to restore paraoxonase activity.

3.P.85 The serum paraoxonase activity changes in patients with chronic renal failure and in patients with hyperlipidemia

1997 ◽  
Vol 134 (1-2) ◽  
pp. 216
Author(s):  
Gy. Paragh ◽  
I. Seres ◽  
Z. Balogh ◽  
Zs. Varga ◽  
I. Kárpáti ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity ◽  
Serum Paraoxonase

scholarly journals Serum paraoxonase activity and protein thiols in chronic renal failure patients

2008 ◽  
Vol 18 (1) ◽  
pp. 13 ◽  
Author(s):  
M Prakash ◽  
JK Shetty ◽  
L Rao ◽  
S Sharma ◽  
A Rodrigues ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity ◽  
Protein Thiols ◽  
Serum Paraoxonase

scholarly journals Serum Paraoxonase (Arylesterase) Activity in Chronic Renal Failure

2011 ◽  
Vol 12 (1) ◽  
pp. 17-20
Author(s):  
Balasubramaniam Gayathri ◽  
Anand Usha ◽  
Duraisamy Vijaya
Keyword(s):  
Risk Factors ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Predictive Accuracy ◽  
Background Mortality ◽  
Anti Oxidant ◽  
Traditional Risk Factors ◽  
Artery Disease ◽  
Serum Paraoxonase ◽  
Control Study

Background: Mortality rates are higher among patients with chronic renal failure with a good proportion of this excess burden being attributable to cardiovascular disease. This excess risk is not entirely explained by elevated traditional risk factors. Among the non-traditional risk factors, serum paraoxonase (Arylesterase) activity is an important one. Materials and Methods: It was a case-control study which included total 127 subjects, 44 were non-dialysis CKD patients, 33 Heamodialysis dependent patients and 50 healthy controls. HDL-C, Apo-A and serum paraoxonase (Arylesterase) activity was estimated and compared with normal control population. Results: Serum Arylesterase activity, a measure of PON was significantly lower in CRF (on conservative management and on hemodialysis) compared to controls. Conclusion: Measurement of anti oxidant capacity of HDL-C may improve the predictive accuracy of atherosclerotic coronary artery disease, providing new strategies for the prevention and treatment of accelerated atherosclerosis in chronic renal failure. Keyword: Serum paraoxonase (Arylesterase); chronic renal failure; AtherosclerosisDOI: 10.3329/jom.v12i1.5638J Medicine 2011; 12 : 17-20

scholarly journals Serum Paraoxonase and Platelet-Activating Factor Acetylhydrolase in Chronic Renal Failure

1998 ◽  
Vol 44 (1) ◽  
pp. 179-181 ◽  
Author(s):  
Oliver Hasselwander ◽  
Dorothy McMaster ◽  
Damian G Fogarty ◽  
A Peter Maxwell ◽  
D Paul Nicholls ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Platelet Activating Factor ◽  
Platelet Activating Factor Acetylhydrolase ◽  
Serum Paraoxonase

scholarly journals Paraoxonase activity stimulation by salts is higher in chronic renal failure patients than in controls.

1998 ◽  
Vol 13 (3) ◽  
pp. 816-816 ◽  
Author(s):  
T. Dantoine ◽  
J. Debord ◽  
J. P. Charmes ◽  
L. Merle ◽  
C. Leroux-Robert
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity

scholarly journals Paraoxonase activity stimulation by salts is higher in chronic renal failure patients than in controls

1998 ◽  
Vol 13 (3) ◽  
pp. 845-845 ◽  
Author(s):  
T. Dantoine ◽  
J. Debord ◽  
J. Charmes ◽  
L. Merle ◽  
C. Leroux-Robert
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Paraoxonase Activity

Serum Paraoxonase (Arylesterase) activity in chronic renal failure

2011 ◽  
Vol 1 (1) ◽  
pp. 32-33
Author(s):  
Gayathri Balasubramaniam ◽  
Mohana Priya ◽  
Usha Anand ◽  
Viyaya Duraiswamy ◽  
Anand C V
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Paraoxonase
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