Low Nitric Oxide Production in Patients with Chronic Renal Failure

Nephron ◽  
1998 ◽  
Vol 79 (3) ◽  
pp. 265-268 ◽  
Author(s):  
M. Blum ◽  
T. Yachnin ◽  
Y. Wollman ◽  
T. Chernihovsky ◽  
G. Peer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nitric Oxide Production ◽  
Oxide Production

Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure

1999 ◽  
Vol 96 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Akihiro MATSUMOTO ◽  
Yasunobu HIRATA ◽  
Masao KAKOKI ◽  
Daisuke NAGATA ◽  
Shin-ichi MOMOMURA ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Exhaled Nitric Oxide ◽  
Simultaneous Increase ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Endogenous Nitric Oxide

Nitric oxide exerts multiple effects on renal function. It remains unclear whether endogenous nitric oxide production is increased or decreased in patients with chronic renal failure. To evaluate endogenous nitric oxide production in these patients we studied exhaled nitric oxide output by an ozone chemiluminescence method and plasma NO2-/NO3- levels by the Griess method in 40 patients with end-stage chronic renal failure who underwent regular continuous ambulatory peritoneal dialysis (n = 30) or haemodialysis (n = 10), and in 28 healthy subjects. Patients with chronic renal failure had a higher exhaled nitric oxide concentration [39±3 versus 19±1 parts per billion, (mean±S.E.M.), P< 0.0001], a greater nitric oxide output (177±11 versus 96±7 ;nl·min-1·m-2, P< 0.001) and a higher plasma NO2-/NO3- concentration (96±14 versus 33±4 ;μmol, P< 0.01) than controls. These values did not differ between patients on haemodialysis and those on continuous ambulatory peritoneal dialysis. Patients with chronic renal failure had significantly higher plasma concentrations of both interleukin-1β and interferon-γ than controls. The exhaled nitric oxide output did not correlate with plasma NO2-/NO3- or with peritoneal dialysate NO2-/NO3-, but plasma NO2-/NO3- correlated with dialysate NO2-/NO3- in patients who underwent continuous ambulatory peritoneal dialysis (r = 0.77, P< 0.01). Haemodialysis for 4 ;h acutely decreased plasma NO2-/NO3- (92±17 versus 50±8 ;μmol, P< 0.05) and cGMP concentration (16.5±4.3 versus 5.1±1.7 ;pmol/ml, P< 0.01), but did not decrease exhaled nitric oxide output. The increase in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia.

scholarly journals Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production

1995 ◽  
Vol 47 (6) ◽  
pp. 1515-1521 ◽  
Author(s):  
Ishmail Ashab ◽  
Gary Peer ◽  
Miriam Blum ◽  
Yoram Wollman ◽  
Tamara Chernihovsky ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Oral Administration ◽  
Nitric Oxide Production ◽  
Oxide Production

scholarly journals Nitric Oxide Production Is Reduced in Patients With Chronic Renal Failure

1999 ◽  
Vol 19 (5) ◽  
pp. 1168-1172 ◽  
Author(s):  
Robert Wever ◽  
Peter Boer ◽  
Michel Hijmering ◽  
Erik Stroes ◽  
Marianne Verhaar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nitric Oxide Production ◽  
Oxide Production

502: Pressure Induces Nitric Oxide Production by Human Ureteral Cells in Vitro

2005 ◽  
Vol 173 (4S) ◽  
pp. 137-137
Author(s):  
Michael M. Ohebshalom ◽  
Stella K. Maeng ◽  
Jie Chen ◽  
Dix P. Poppas ◽  
Diane Felsen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production

Effect of Nelumbo nucifera on nitric oxide production and co-stimulatory molecules

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
D Mukherjee ◽  
TN Khatua ◽  
A Biswas ◽  
T Biswas ◽  
BP Saha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nelumbo Nucifera ◽  
Nitric Oxide Production ◽  
Oxide Production
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