Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura

1999 ◽  
Vol 102 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Javier de la Rubia ◽  
Aurelio López ◽  
Francisco Arriaga ◽  
Ana Rosa Cid ◽  
Ana Isabel Vicente ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Combined Therapy ◽  
Thrombocytopenic Purpura

scholarly journals Elevated platelet-bound IgG associated with an episode of thrombotic thrombocytopenic purpura

Blood ◽  
1981 ◽  
Vol 58 (4) ◽  
pp. 682-684 ◽  
Author(s):  
PJ Sims ◽  
EB Boswell
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Successful Treatment ◽  
Combined Therapy ◽  
Complete Recovery ◽  
Antiplatelet Drugs ◽  
High Dose ◽  
Normal Range ◽  
Thrombocytopenic Purpura

Abstract The level of platelet-associated IgG (PAIgG) were measured during the successful treatment of a patient with thrombotic thrombocytopenic purpura. Prior to therapy. PAIgG was found to be markedly elevated to 195 fg/cell (normal range 0--3.5 fg/cell). The institution of combined therapy with intensive plasma exchange transfusions, high-dose steroids, and antiplatelet drugs resulted in a complete recovery and a decline in PAIgG to the normal range. The possible role of platelet antibody in the pathogenesis of this disorder is discussed.

scholarly journals Elevated platelet-bound IgG associated with an episode of thrombotic thrombocytopenic purpura

Blood ◽  
1981 ◽  
Vol 58 (4) ◽  
pp. 682-684
Author(s):  
PJ Sims ◽  
EB Boswell
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Successful Treatment ◽  
Combined Therapy ◽  
Complete Recovery ◽  
Antiplatelet Drugs ◽  
High Dose ◽  
Normal Range ◽  
Thrombocytopenic Purpura

The level of platelet-associated IgG (PAIgG) were measured during the successful treatment of a patient with thrombotic thrombocytopenic purpura. Prior to therapy. PAIgG was found to be markedly elevated to 195 fg/cell (normal range 0--3.5 fg/cell). The institution of combined therapy with intensive plasma exchange transfusions, high-dose steroids, and antiplatelet drugs resulted in a complete recovery and a decline in PAIgG to the normal range. The possible role of platelet antibody in the pathogenesis of this disorder is discussed.

scholarly journals A Signet Ring Cell Carcinoma Presented as Refractory Acquired Thrombotic Thrombocytopenic Purpura

2020 ◽  
Vol 13 (3) ◽  
pp. 1368-1372
Author(s):  
Umit Yavuz Malkan ◽  
Murat Albayrak ◽  
Hacer Berna Ozturk ◽  
Merih Reis Aras ◽  
Bugra Saglam ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Unknown Origin ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Thrombocytopenic Purpura ◽  
Signet Ring ◽  
Gastric Endoscopy ◽  
Ring Cell

Microangiopathic hemolytic anemia (MAHA) can be observed as a paraneoplastic syndrome (PS) in certain tumors. MAHA-related signet ring cell carcinoma (SRCC) of an unknown origin is very infrequent. Herein we present a SRCC case presented with refractory acquired thrombotic thrombocytopenic purpura (TTP). A 35-year-old man applied to the emergency service with fatigue and headache. His laboratory tests resulted as white blood cell 9,020/µL, hemoglobin 3.5 g/dL, platelet 18,000/µL. Schistocytes, micro-spherocytes, and thrombocytopenia were observed in his blood smear. MAHA was present and he was considered as having TTP. Plasma exchange treatment was initiated; however, he was refractory to this treatment. Thorax and abdomen computerized tomography revealed thickening of minor curvature in stomach corpus with hepatogastric and paraceliac lymphadenopathy. Bone marrow (BM) investigation by our clinic resulted as the metastasis of adenocarcinoma. Ulceration and necrosis were observed by gastric endoscopy procedure. Biopsy was taken during endoscopic intervention, which resulted as SRCC. MAHA may be seen as a PS in some tumors, especially gastric cancers. Tumor-related MAHA is generally accompanied by BM metastases. As a result, BM investigation may be used as the main diagnostic method to find the underlying cancer. The clinical course of cases with tumor-related MAHA is usually poor, and these cases are usually refractory to plasma exchange treatment. In conclusion, physicians should suspect a malignancy and BM involvement when faced with a case of refractory TTP.

Thrombotic Thrombocytopenic Purpura Associated with Transient Chromosomal Aberrations: Successful Treatment with Plasma Exchange

1990 ◽  
Vol 84 (4) ◽  
pp. 209-211
Author(s):  
Yoshitoshi Itoh ◽  
Tomoyuki Taniguchi ◽  
Naoshi Takeyama ◽  
Hideki Kuriki ◽  
Takaya Tanaka
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Successful Treatment ◽  
Chromosomal Aberrations ◽  
Thrombocytopenic Purpura

Plasma exchange for treatment of thrombotic thrombocytopenic purpura in critically ill patients

1997 ◽  
Vol 23 (1) ◽  
pp. 44-50 ◽  
Author(s):  
P. Knöbl ◽  
C. Rintelen ◽  
G. Kornek ◽  
C. Wiltschke ◽  
P. Kalhs ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Thrombocytopenic Purpura
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