A Study on the Lectin Reactivity of Alpha-Fetoprotein Produced by Hepatoid Adenocarcinomas and Yolk Sac Tumors

Tumor Biology ◽  
1999 ◽  
Vol 20 (4) ◽  
pp. 212-217 ◽  
Author(s):  
Ritsu Yamamoto ◽  
Yukio Wakui ◽  
Kazuhisa Taketa ◽  
Hiroshi Ishikura ◽  
Noriaki Sakuragi ◽  
...  
Keyword(s):  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumors

scholarly journals Ovarian Yolk Sac Tumors; Does Age Matter?

2018 ◽  
Vol 28 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Cecile Faure Conter ◽  
Caihong Xia ◽  
David Gershenson ◽  
Jean Hurteau ◽  
Al Covens ◽  
...  
Keyword(s):  
United States ◽  
Overall Survival ◽  
Clinical Trials ◽  
Germ Cell ◽  
Age Groups ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Event Free Survival ◽  
Free Survival ◽  
Yolk Sac Tumors

BackgroundWhereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors.MethodsThe Malignant Germ Cell International Consortium data set included 6 pediatric clinical trials (United States, United Kingdom, and France) and 2 adult gynecology clinical trials (United States). Any patient with an O-YST that was International Federation of Gynecology and Obstetrics stage IC or higher and treated with a platinum-based chemotherapy was eligible. Age was modeled as a continuous and a categorical variable (children, 0-10 years; adolescents, 11–17 years; and adults, ≥18 years). In addition, analyses to establish the optimal cut point for age were conducted. Tumors were coded as pure YST (YST +/− teratoma), mixed YST (YST + other malignant germ cell component), or putative YST (“mixed” germ cell tumor + alpha-fetoprotein >1000 ng/mL). Histology, stage (II/III vs IV), preoperative alpha-fetoprotein levels (<1000; 1000–10,000, or >10,000 ng/mL), and chemotherapeutic regimen (carboplatin vs cisplatin) were analyzed as covariates.ResultsTwo hundred fifty-one patients (median age, 13 years; range, 0–38 years) were identified (78 children, 139 adolescents, and 34 adults). Histology was pure, mixed, and putative in 129, 56, and 66 cases, respectively. Twenty-six patients had stage IV disease, similarly distributed in the 3 age groups. Median follow-up was 5.8 years. The overall 5-year event-free survival and overall survival was 91% (95% confidence interval, 87%–94%) and 96% (92%–98%), respectively. Age did not affect risk of event or death, modeled either as a categorical or continuous variable. Analysis failed to identify an age cut point that affected risk. None of the other covariates investigated had a prognostic impact on event-free survival or overall survival.ConclusionsOvarian yolk sac tumors have an excellent outcome across all age-groups. Age has no apparent impact on the probability of event or death, allowing pediatric and gynecologic oncologists to enroll patients onto joint pediatric and adult trials.

Yolk sac tumors and alpha-fetoprotein in first year of life

Urology ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 79-80 ◽  
Author(s):  
Jack A. Brewer ◽  
Edward S. Tank
Keyword(s):  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
First Year ◽  
Yolk Sac Tumors ◽  
First Year Of Life

Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors

2016 ◽  
Vol 142 (3) ◽  
pp. 452-457 ◽  
Author(s):  
Thibault de la Motte Rouge ◽  
Patricia Pautier ◽  
Catherine Genestie ◽  
Annie Rey ◽  
Sébastien Gouy ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumors ◽  
Serum Alpha Fetoprotein

scholarly journals Immunocytochemical localization of oncodevelopmental proteins in human germ cell and hepatic tumors.

1978 ◽  
Vol 26 (7) ◽  
pp. 523-531 ◽  
Author(s):  
P E Palmer ◽  
H J Wolfe
Keyword(s):  
Tumor Tissue ◽  
Fetal Liver ◽  
Normal Serum ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Gene Products ◽  
Hepatic Tumors ◽  
Yolk Sac Tumors ◽  
Alpha 1 Antitrypsin ◽  
Tumor Types

In a combined tissue and serum study alpha-1-antitrypsin (AAT) and alpha-fetoprotein are demonstrated in parallel within tumor tissue inclusions in both endodermal sinus (yolk sac) tumors and malignant hepatomas, and AAT is demonstrated as a marker in both neoplastic and preneoplastic liver lesions occurring in oral contraceptive users, all in association with normal serum AAT phenotype. The tumor inclusions in the first two instances differ immunocytochemically from AAT liver cell globules found in inherited AAT deficiency, which are unreactive for alpha-fetoprotein. It is concluded that unlike the molecular basis of storage associated with AAT phenotypic variation, the tumor inclusions reflect a separate, nongenetic mechanism of AAT storage, which may be epigenetic in nature. AAT and alpha-fetoprotein both are synthesized normally in yolk sac and fetal liver, a parallelism which disappears soon after birth. The reexpression of both proteins in two distinct tumor types arising from endodermal origins (yolk sac and liver), suggests that these markers may represent reemerging fetal gene products, a phenomenon previously proposed only for alpha-fetoprotein, a prototypic "oncofetal antigen."

scholarly journals Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xuan Zong ◽  
Ying Zhang ◽  
Xinxin Peng ◽  
Dongyan Cao ◽  
Mei Yu ◽  
...  
Keyword(s):  
Copy Number Alteration ◽  
Germ Cell Tumors ◽  
Gonadal Development ◽  
Yolk Sac ◽  
Mutational Signatures ◽  
Whole Exome ◽  
Genomic Landscape ◽  
Yolk Sac Tumors ◽  
Molecular Aberrations

AbstractYolk sac tumors (YSTs) are a major histological subtype of malignant ovarian germ cell tumors with a relatively poor prognosis. The molecular basis of this disease has not been thoroughly characterized at the genomic level. Here we perform whole-exome and RNA sequencing on 41 clinical tumor samples from 30 YST patients, with distinct responses to cisplatin-based chemotherapy. We show that microsatellite instability status and mutational signatures are informative of chemoresistance. We identify somatic driver candidates, including significantly mutated genes KRAS and KIT and copy-number alteration drivers, including deleted ARID1A and PARK2, and amplified ZNF217, CDKN1B, and KRAS. YSTs have very infrequent TP53 mutations, whereas the tumors from patients with abnormal gonadal development contain both KRAS and TP53 mutations. We further reveal a role of OVOL2 overexpression in YST resistance to cisplatin. This study lays a critical foundation for understanding key molecular aberrations in YSTs and developing related therapeutic strategies.

scholarly journals Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

2021 ◽  
Author(s):  
Clinton Hall ◽  
Johnni Hansen ◽  
Jørn Olsen ◽  
Di He ◽  
Ondine S. von Ehrenstein ◽  
...  
Keyword(s):  
Germ Cell ◽  
Maternal Employment ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Social Contact ◽  
Case Control ◽  
Yolk Sac ◽  
Parental Occupation ◽  
Yolk Sac Tumors ◽  
Control Study

Abstract Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.

scholarly journals Nasopharyngeal Yolk Sac Tumors: A Rare Pediatric Occurrence

2013 ◽  
Vol 92 (8) ◽  
pp. 336-338
Author(s):  
Belinda Mantle ◽  
Ryan F. Osborne
Keyword(s):  
Yolk Sac ◽  
Yolk Sac Tumors
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