Expression of Cathepsin B in Small Cell Lung Carcinoma Cells in Relation to in vitro Invasiveness

Tumor Biology ◽  
1998 ◽  
Vol 19 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Tatsuhito Nakae ◽  
Takeshi Horai ◽  
Fumio Imamura ◽  
Hitoshi Akedo ◽  
Kazuya Higashino NIL
Keyword(s):  
Lung Carcinoma ◽  
Cathepsin B ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cells ◽  
In Vitro Invasiveness

scholarly journals No-Modified Saquinavir is Equally Efficient Against Doxorubicin Sensitive and Resistant Non-Small Cell Lung Carcinoma Cells / MODIFIKOVANA KOVANA FORMA SAKVINAVIRA EFIKASNO SU PRIMI RA RAST ĆELIJA NESITNOĆELIJSKOG KARCINOMA PLUĆA RAZLIČITE OSETUIVOSTI NA DOKSORUBICIN

2013 ◽  
Vol 32 (4) ◽  
pp. 406-416 ◽  
Author(s):  
Sanja Mijatović ◽  
Milica Pešić ◽  
Marija Mojić ◽  
Jasna Banković ◽  
Đorde Miljković ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Antineoplastic Agent ◽  
Small Cell ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cells ◽  
Hiv Inhibitor

Summary Background: The NO-modified form of the HIV inhibitor saquinavir (Saq-NO) inhibited the growth of a variety of can- cer cell lines in vitro and in vivo more potently than the orig- inal compound in a nontoxic fashion. In addition, chemo- and immunosensitizing properties were observed. The aim of the present study was to evaluate its anticancer action against non-small cell lung carcinoma cells in their doxoru- bicin (DOXO) sensitive and resistant phenotype (NCI-H460 and NCI-H460/R). Methods: The viability of cells was analyzed by MTT and crystal violet assays. DR5 expression was estimated by real time RT-PCR and flow cytometry. Activity of P-glycoprotein (P-gp) pumps was evaluated by the Rho123 accumulation assay. Results: Saq-NO diminished the viability of lung cancer cells through induction of cell cycle arrest in the Gq/G1 phase in- dependently of the overexpression of the P-gp pumps. In addition, Saq-NO elevated or completely reconstituted the doxorubicin efficacy in NCI-H460 and NCI-H460/R, respec- tively. The chemosensitizing effect in DOXO resistant cells was a consequence of P-gp inhibition which was found to be more potent than that observed with dex-verapamil, a con- ventional inhibitor of P-gp. Sensitization to DOXO upon Saq- NO was accompanied by elevated DR5 expression, but the resistance to TRAIL was not abrogated. Conclusions: The NO-modified HIV inhibitor saquinavir dis- played equal antiproliferative and chemosensitizing proper- ties in DOXO sensitive and resistant non-small cell lung car- cinoma cells, suggesting the importance of the evaluation of this drug as an antineoplastic agent.

scholarly journals LSD1 modulates the non-canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
So-Young Lim ◽  
Iris Macheleidt ◽  
Priya Dalvi ◽  
Stephan C. Schäfer ◽  
Martin Kerick ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Integrin Β3 ◽  
Lung Carcinoma Cells

scholarly journals PKCα Mediates mTORC1 Activation in Non‐Small Cell Lung Carcinoma Cells with EGFR Deletion Mutation

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mohamed Fouda Salama ◽  
Mengling Liu ◽  
Christopher Clarke ◽  
Mel Pilar Espaillat ◽  
John Haley ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Deletion Mutation ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cells ◽  
Mtorc1 Activation
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