Fever, Weight Loss and Night Sweat on Corticosteroid Therapy for COPD

Jens Schreiber; Ulf Greinert; Sabine Rüsch-Gerdes; Werner Lotz; Max Schlaak; Joachim Müller-Quernheim

doi:10.1159/000029437

Prognostic value of different B symptoms in upper aerodigestive tract NK/T-cell lymphoma

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e19544 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e19544-e19544

Author(s):

J. Xiao ◽

C. Guo ◽

L. Zhai ◽

H. Li ◽

X. Fu ◽

...

Keyword(s):

Weight Loss ◽

T Cell ◽

Prognostic Value ◽

Cell Lymphoma ◽

Univariate Analysis ◽

Night Sweat ◽

Aerodigestive Tract ◽

T Cell Lymphoma ◽

Upper Aerodigestive Tract ◽

Ann Arbor

e19544 Background: Extranodal NK/T-cell lymphoma (ENKL) is a rare disease originated from NK or toxic T cells. ENKL arising from the upper aerodigestive tract (UNKTL) is a newly recognized subtype and commonly presents with B symptoms. This study is to investigate the prognostic value of different B symptoms in UNKTL. Methods: UNKTL cases with detailed clinical, pathological and prognostic data in our center since 2001 to 2007 were retrospectively analyzed with the major study endpoint of overall survival (OS). Central pathological review was performed. Survival curves were estimated by Kaplan-Meier method and tested by Log Rank method. Statistically significant factors in univariate analysis were then included in multivariate analysis. B symptoms were defined as fever, night sweat and weight loss according to the Ann Arbor Cotswolds meeting. The predictive values of survival for each type of B symptoms were studied independently. Results: 172 cases of UNKTL with a median follow-up duration of 27.4 months were included. 45 ladies and 127 gentlemen had a median age of 43 years. 98 cases were Ann Arbor stage I, 54 were stage II and the remaining 20 cases were stage III or IV. About half of the patients present B symptoms: 82 had fever, 5 had night sweat and 6 present weight loss. Totally 18 patients had ECOG PS larger than 1. The 5-year OS rate of the whole group is 41.8%. Patients with persistent fever before treatment indicated a poor outcome in the univariate analysis (p=.033) and its prognostic value was also confirmed by the Cox regression (p=.030) whereas those of night sweat and weight loss were not (p= .960 and .824 respectively). Conclusions: B symptoms were common in UNKTL patients. Our data suggested that only fever among the three types of B symptoms was independent prognostic factor for UNKTL but it still needs further confirmation. No significant financial relationships to disclose.

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Cronkhite-Canada Syndrome Successfully Treated by Corticosteroids before Presenting Typical Ectodermal Symptoms

Case Reports in Gastroenterology ◽

10.1159/000510920 ◽

2020 ◽

Vol 14 (3) ◽

pp. 561-569

Author(s):

Kazumoto Murata ◽

Kiichi Sato ◽

Shinya Okada ◽

Daisuke Suto ◽

Takaaki Otake ◽

...

Keyword(s):

Weight Loss ◽

Family History ◽

Corticosteroid Therapy ◽

Terminal Ileum ◽

Chronic Diarrhea ◽

Endoscopic Examination ◽

Hyperplastic Polyps ◽

Gastrointestinal Polyposis ◽

History Of ◽

Gastric Polyposis

Cronkhite-Canada syndrome (CCS) is a rare disease characterized by diffuse gastrointestinal polyposis with chronic diarrhea and ectodermal change, but its etiology is unknown. We present a case at the age of 26 years complaining of epigastralgia and weight loss. Endoscopic examination revealed extensive diffuse polypoid lesions of the stomach and the terminal ileum, all of which showed hyperplastic polyps pathologically. There were no polypoid lesions in his colon. He has no family history of diffuse gastrointestinal polyposis. Diffuse gastrointestinal hyperplastic polyposis without any hereditary association led us to suspect this case as CCS although he did not show chronic diarrhea and any ectodermal symptoms such as onychodystrophy, alopecia, and hyperpigmentation. After initiation of a corticosteroid therapy, his epigastralgia disappeared and he gained appetite and weight, accompanied by normalization of serum albumin levels. Endoscopic examination 1 year after initiation of corticosteroid therapy revealed a decrease in the number of gastric polyposis and those inflammations. This rare young case may suggest that early therapeutic intervention with corticosteroids could improve the prognosis of CCS, preventing not only malnutrition but also appearance of several ectodermal symptoms.

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