A Study of Peripheral Airway Findings Using an Ultrathin Bronchofiberscope and Bronchoalveolar Lavage Fluid with Diffuse Panbronchiolitis

Respiration ◽  
1998 ◽  
Vol 65 (6) ◽  
pp. 433-440 ◽  
Author(s):  
Masayuki Kikawada ◽  
Yuichi Ichinose ◽  
Kazushige Minemura ◽  
Masaru Takasaki ◽  
Keisuke Toyama
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Diffuse Panbronchiolitis ◽  
Peripheral Airway

scholarly journals Elastase Activity in Bronchoalveolar Lavage Fluid from Patients with Diffuse Panbronchiolitis

1991 ◽  
Vol 65 (6) ◽  
pp. 672-680 ◽  
Author(s):  
Hideaki NINOMIYA ◽  
Yoichiro ICHIKAWA ◽  
Hideyuki KOGA ◽  
Takafumi YANO ◽  
Kotaro OIZUMI
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Elastase Activity ◽  
Diffuse Panbronchiolitis

Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways

1996 ◽  
Vol 81 (3) ◽  
pp. 1255-1263 ◽  
Author(s):  
C. Omori ◽  
P. Tagari ◽  
A. N. Freed
Keyword(s):  
Bronchoalveolar Lavage ◽  
Wall Temperature ◽  
Airway Resistance ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Airway Wall ◽  
Airway Reactivity ◽  
Dry Air ◽  
Peripheral Airways ◽  
Peripheral Airway

We examined the role of leukotrienes (LTs) in the development of dry air-induced bronchoconstriction (AIB) in canine peripheral airways. Airway reactivity to exogenous LTs was first tested by using an LTD4 aerosol challenge: peripheral airway resistance increased approximately 130 +/- 51% (n = 4) above baseline when compared with its vehicle control. AIB was then assessed by measuring peripheral airway resistance after, and airway wall temperature during, a dry air challenge (DAC). Treatment with a peptidoleukotriene biosynthesis inhibitor (MK-0591) attenuated AIB by approximately 65% without altering airway wall temperature. The fact that MK-0591 did not alter airway reactivity to aerosolized acetylcholine and completely inhibited Ca2+ ionophore-induced LTB4 generation in canine whole blood attests to the specificity of the drug. Treatment with MK-0591 did not affect the increased number of epithelial cells recovered in bronchoalveolar lavage fluid 5 min after DAC. Concentrations of LTs and other eicosanoids in bronchoalveolar lavage fluid from vehicle-treated DAC airways were increased above baseline values; only LTs were reduced by MK-0591. Before MK-0591, AIB was significantly correlated with the dry air-induced generation of LTC4, LTD4, and LTE4. After treatment with MK-0591, AIB was correlated with thromboxane B2, prostaglandin (PG) F2 alpha, and PGE2. We conclude that hyperpnea with dry air stimulates local production and release of LTs in canine bronchi and, alone with the generation of bronchoconstricting and bronchodilating PGs, plays a central role in the modulation of AIB.

Neutrophilia in Bronchoalveolar Lavage Fluid of Diffuse Panbronchiolitis

CHEST Journal ◽  
1990 ◽  
Vol 98 (4) ◽  
pp. 917-923 ◽  
Author(s):  
Yoichim Ichikawa ◽  
Hideyuki Koga ◽  
Masako Tanaka ◽  
Masahiro Nakamura ◽  
Naoto Tokunaga ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Diffuse Panbronchiolitis

Leukotriene B4 in Bronchoalveolar Lavage Fluid of Patients With Diffuse Panbronchiolitis

CHEST Journal ◽  
1995 ◽  
Vol 108 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Hiroshige Oda ◽  
Jun-Ichi Kadota ◽  
Shigeru Kohno ◽  
Kohei Hara
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Leukotriene B4 ◽  
Diffuse Panbronchiolitis
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