Acute Natriuretic Effect of Fasidotrilat, a Mixed Inhibitor of Neutral Endopeptidase and Angiotensin I-Converting Enzyme, in Rats with Heart Failure

Pharmacology ◽  
1998 ◽  
Vol 56 (6) ◽  
pp. 291-296 ◽  
Author(s):  
Christine Marie ◽  
Claude Mossiat ◽  
Jeanne-Marie Lecomte ◽  
Jean Bralet
Keyword(s):  
Heart Failure ◽  
Neutral Endopeptidase ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme ◽  
Natriuretic Effect

scholarly journals Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans

2004 ◽  
Vol 18 (2) ◽  
pp. 119-125 ◽  
Author(s):  
J E Jalil ◽  
M P Ocaranza ◽  
C Oliveri ◽  
S Córdova ◽  
I Godoy ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Neutral Endopeptidase ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme

Inhibition of peptidases in the control of blood pressure

2002 ◽  
Vol 38 ◽  
pp. 129-139 ◽  
Author(s):  
Eiji Kubota ◽  
Rachel G Dean ◽  
Leanne C Balding ◽  
Louise M Burrell
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Single Molecule ◽  
Neutral Endopeptidase ◽  
Electrolyte Balance ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Vasopeptidase Inhibitor ◽  
Membrane Bound ◽  
Simultaneous Inhibition

The natriuretic peptide and renin-angiotensin systems are physiological counterparts with opposite roles in the regulation of electrolyte balance and blood pressure. In both systems, membrane-bound, zinc-dependent peptidases play an important role in the inactivation or activation of the system. Angiotensin-converting enzyme (ACE) converts angiotensin I into angiotensin II, and neutral endopeptidase (NEP) degrades the natriuretic peptides. Simultaneous inhibition NEP and ACE by a single molecule (a vasopeptidase inhibitor) is a new therapeutic approach in hypertension. Wider applications for vasopeptidase inhibitors being studied include their role as cardioprotective agents in heart failure, as renoprotective agents in chronic renal failure and diabetic nephropathy, and as vasculoprotective agents in endothelial dysfunction and athersclerosis.

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