Ciliary Beat Frequency, Olfaction and Endoscopic Sinus Surgery

ORL ◽  
1998 ◽  
Vol 60 (4) ◽  
pp. 202-205 ◽  
Author(s):  
Balegh Abdel-Hak ◽  
Andreas Gunkel ◽  
Georg Kanonier ◽  
Anneliese Schrott-Fischer ◽  
Hanno Ulmer ◽  
...  
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Sinus Surgery ◽  
Ciliary Beat

Functional endoscopic sinus surgery in the management of chronic rhinosinusitis. An objective assessment

1991 ◽  
Vol 105 (10) ◽  
pp. 832-835 ◽  
Author(s):  
Valerie J. Lund ◽  
Mats Holmstrom ◽  
Glenis K. Scadding
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Clinical Success ◽  
Objective Assessment ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Quantitative Evidence ◽  
Chronic Rhino Sinusitis ◽  
Ciliary Beat

AbstractConsiderable clinical success has been claimed for functional endoscopic sinus surgery but objective assessment of prospective series is lacking in the literature. Twenty-four patients with chronic rhino-sinusitis underwent assessment of symptoms by visual analogue scoring, nasomucociliary function by ciliary beat frequency, olfaction by qualitative olfactometry and nasal airway resistance by anterior rhinomanometry pre- and post-operatively. This demonstrated a significant improvement in all symptoms examined and in ciliary beat frequency. Quantitative olfaction and anterior rhinomanometry were not improved despite diminished symptoms. These results offer quantitative evidence of clinical improvement following functional endoscopic sinus surgery which supports the pathophysiological concepts on which the technique is based.

Endonasal Sinus Surgery Improves Mucociliary Transport in Severe Chronic Sinusitis

1997 ◽  
Vol 11 (4) ◽  
pp. 271-276 ◽  
Author(s):  
Bernol Hafner ◽  
Spiros Davris ◽  
Herbert Riechelmann ◽  
Wolf J. Mann ◽  
Ronald G. Amedee
Keyword(s):  
Chronic Sinusitis ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Sinus Surgery ◽  
Mucociliary Transport ◽  
Endonasal Sinus Surgery ◽  
Saccharine Test ◽  
Interference Contrast Microscopy ◽  
Respiratory Cells ◽  
Ciliary Beat

A total of 22 patients with extensive chronic sinusitis were examined before and 7.2 ± 1.1 months after microscopic endonasal sinus surgery. Pre- and postoperative nasal mucociliary transport was measured using a modified saccharine test and ciliary beat frequency of nasal respiratory cells using video interference contrast microscopy. In patients suffering from chronic sinusitis, nasal ciliary beat frequency was significantly lower (8.0 ± 1.8 Hz) than in normals (9.5 ± 1.7 Hz, p < 0.02). Following endonasal sinus surgery, ciliary beat frequency in patients with chronic sinusitis remained reduced (8.3 ± 1.2 Hz). Nasal mucociliary transport time was significantly (p < 0.05) longer (20.9 ± 9.4 minutes) in patients with chronic sinusitis than in normals (14.9 ± 8.4 minutes). Nasal mucociliary transport improved significantly (p < 0.05) to 13.8 ± 8.4 minutes in 17 of 22 patients without recurrent sinusitis and remained prolonged (20.6 ± 7.7 minutes) in 5 of 22 patients with recurrent disease. These data suggest that ciliary beat frequency of nasal respiratory cells and nasal mucus transport are impaired in patients suffering from chronic sinusitis. After microscopic endonasal sinus surgery, impaired mucociliary transport is improved, and ciliary beat frequency remains lower than in normals.

scholarly journals The impact of zinc supplementation on the outcome of endoscopic sinus surgery and ciliary function of the nasal mucosa in children with chronic rhinosinusitis

2021 ◽  
pp. 73-82
Author(s):  
С.И. Алексеенко ◽  
А.В. Скальный ◽  
С.А. Карпищенко ◽  
С.А. Артюшкин ◽  
С.В. Барашкова ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Endoscopic Sinus Surgery ◽  
Inductively Coupled Plasma ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Sinus Surgery ◽  
Ciliary Activity ◽  
Ciliary Function ◽  
The Impact

Несмотря на указания на роль цинка в функции реснитчатого эпителия, данные относительно влияния коррекции обмена цинка на цилиарную функцию у пациентов с хроническим риносинуситом отсутствуют. Целью настоящего исследования явилась оценка эффективности хирургического лечения, активности мукоцилиарного аппарата, а также местной воспалительной реакции слизистой оболочки носа в послеоперационном периоде у детей с хроническим риносинуситом на фоне применения цинка. Методы. Обследовано 192 ребенка с хроническим риносинуситом, в лечении которых применялась эндоскопическая риносинусохирургия. Из них 131 ребенок в послеоперационном периоде получал стандартные назначения, тогда как 61 ребенок дополнительно получал цинк в суточной дозе 10 мг в течение 90 дней. Оценка концентрации цинка в сыворотке крови осуществлялась методом ИСП-МС. Для определения функции цилий использована видеоцитоморфометрия. Определение эффективности лечения осуществлялось с использованием опросника SNOT-20, а также шкал Лунд-Кеннеди и Лунд-Маккей. Результаты. Проведение эндоскопической операции приводило к достоверному снижению значений шкал SNOT-20, Лунд-Кеннеди и Лунд-Маккей у пациентов вне зависимости от приема цинка. В то же время, пациенты, принимавшие цинк, характеризовались достоверно меньшим риском ревизионной хирургии. Цинк также оказывал значительное влияние на функционирование реснитчатого эпителия. В частности, к 12-му месяцу наблюдения количество клеток с подвижными цилиями, частота биения цилий, длина цилий и выживаемость клеток у пациентов, принимавших цинк, превышала соответствующие показатели в контрольной группе. Повышение уровня цинка в организме также сопровождалось многократным снижением количества инфильтрирующих слизистую оболочку нейтрофилов и лимфоцитов. Заключение. Предполагается, что цинк ускоряет репаративные процессы в слизистой оболочке носа и обладает противовоспалительным действием. Despite the presence of certain indications of the role of zinc in ciliated epithelium functioning, data on the potential effect of Zn supplementation in ciliary function in patients with chronic rhinosinusitis are absent. The aim of this study was to evaluate the efficiency of surgical treatment, ciliary activity, as well as local inflammation of nasal mucosa in children with chronic rhinosinusitis undergoing functional endoscopic surgery. Methods. 192 pediatric patients with chronic rhinosinusitis were examined. 131 patients received standard postoperative prescriptions, whereas 61 children received 10 mg Zn daily for 90 days. Serum Zn concentrations were measured by inductively coupled plasma mass spectrometry. Ciliary function was evaluated by video cytomorphometry. Surgery efficiency was assessed with a SNOT-20 questionnaire, as well as with Lund-Kennedy and Lund-Mackay scales. Results. Functional endoscopic sinus surgery resulted in a significant decrease in total SNOT-20, Lund-Kennedy, and Lund-Mackay scores independent of Zn supplementation. At the same time, Zn supplemented patients had a significantly lower risk of revision surgery. Zn also had a significant impact on ciliary function. Specifically, up to the 12th mo postoperatively, Zn supplementation resulted in higher number of cells with motile cilia, ciliary beat frequency, ciliary length, and cell viability as compared to controls. Increased Zn status was also associated with a manyfold decrease in mucosal neutrophil and lymphocyte infiltration. Conclusions. It is proposed that Zn enhances reparative processes in nasal mucosa and possesses anti-inflammatory activity.

Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
S. Alekseenko ◽  
S. Karpischenko ◽  
S. Artyushkin ◽  
S. Barashkova ◽  
I. Anikin
Keyword(s):  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
High Speed ◽  
Beat Frequency ◽  
Neutrophil Infiltration ◽  
Ciliary Beat Frequency ◽  
Substantial Improvement ◽  
Sinus Surgery ◽  
Cell Height ◽  
Ciliary Function

Background: The objective of the study is evaluation of ciliary function and mucosal cytology after endoscopic sinus surgery in children with chronic rhinosinusitis (CRS). Methodology: A total of 132 children with CRS who underwent endoscopic sinus surgery, as well as 15 healthy controls were involved in the study. In this follow-up study patients were examined preoperatively, as well as 3, 6, 9, and 12 months after endoscopic sinus surgery. Assessment of ciliary function and sinonasal mucosal cytology was performed using high-speed videomicroscopy. Lund-Kennedy, Lund-Mackay, and sinonasal outcome test 20 (SNOT20) scores were also evaluated. Results: Total SNOT-20, Lund-Mackay, and Lund-Kennedy values significantly decreased after sinus surgery. In contrast, ciliary function and mucosal cytology only tended to improve after 6 months. 9 months after surgery the number of ciliated cells, ciliary beat frequency, cell viability, and ciliary length were significantly higher than preoperatively. The most significant improvement of ciliary function and cell height was observed 12 months after operation, whereas epithelial dystrophy and neutrophil infiltration were significantly reduced. Conclusions: Substantial improvement was observed only in a year after surgery, whereas 0 to 3 months after the surgery ciliary function was severely impaired thus predisposing to recurrent sinusitis or other complications.

Objective assessment of endoscopic sinus surgery in the management of chronic rhinosinusitis: an update

1994 ◽  
Vol 108 (9) ◽  
pp. 749-753 ◽  
Author(s):  
Valerie J. Lund ◽  
Glenis K. Scadding
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Success ◽  
Subjective Evaluation ◽  
Objective Assessment ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Acoustic Rhinometry ◽  
Sinus Surgery ◽  
Ostiomeatal Complex ◽  
Ciliary Beat

AbstractWhilst clinical success of endoscopic surgery for chronic rhinosinusitis has necessarily depended primarily upon subjective evaluation, a range of objective techniques are now available which may facilitate our interpretation of results. A group of 200 patients underwent assessment of symptoms by sequential visual analogue scoring, olfaction by qualitative and quantitative testing, nasal airflow by forced inspiratory peak flow, anterior rhinomanometry, nasomucociliary function by ciliary beat frequency and nasal topography by acoustic rhinometry performed pre- and post-operatively. Significant improvement was demonstrated in all symptoms examined, olfactory tests and ciliary beat frequency whilst acoustic rhinometry provided an attempt to quantify the surgical cavities. These results offer an interesting perspective on the pathology of rhinosinusitis and the rationale for surgery within the ostiomeatal complex.

Effects of Prostaglandins D, and E2on Ciliary Beat Frequency of Human Upper Respiratory Ciliain Vitro

1995 ◽  
Vol 115 (3) ◽  
pp. 438-442 ◽  
Author(s):  
P. J. Schuil ◽  
M. Ten Berge ◽  
J. M. E. Van Gelder ◽  
K. Graamans ◽  
E. H. Huizing
Keyword(s):  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Upper Respiratory ◽  
Ciliary Beat

Apparatus for endoscopical, laser-based determination of ciliary beat frequency

2005 ◽  
Author(s):  
N. Bogdanovic ◽  
B. Krattiger ◽  
J. Ricka ◽  
M. Frenz
Keyword(s):  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Ciliary Beat

Betadine has a ciliotoxic effect on ciliated human respiratory cells

2014 ◽  
Vol 129 (S1) ◽  
pp. S45-S50 ◽  
Author(s):  
J H Kim ◽  
J Rimmer ◽  
N Mrad ◽  
S Ahmadzada ◽  
R J Harvey
Keyword(s):  
Epithelial Cells ◽  
High Speed ◽  
Imaging System ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Positive Control ◽  
Clinical Dose ◽  
Significant Difference ◽  
Sinonasal Mucosa ◽  
Ciliary Beat

AbstractObjective:This study investigated the effect of Betadine on ciliated human respiratory epithelial cells.Methods:Epithelial cells from human sinonasal mucosa were cultured at the air–liquid interface. The cultures were tested with Hanks' balanced salt solution containing 10 mM HEPES (control), 100 µM ATP (positive control), 5 per cent Betadine or 10 per cent Betadine (clinical dose). Ciliary beat frequency was analysed using a high-speed camera on a computer imaging system.Results:Undiluted 10 per cent Betadine (n = 6) decreased the proportion of actively beating cilia over 1 minute (p < 0.01). Ciliary beat frequency decreased from 11.15 ± 4.64 Hz to no detectable activity. The result was similar with 5 per cent Betadine (n = 7), with no significant difference compared with the 10 per cent solution findings.Conclusion:Betadine, at either 5 and 10 per cent, was ciliotoxic. Caution should be applied to the use of topical Betadine solution on the respiratory mucosal surface.

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