Combination of Bolus 5-Fluorouracil, Folinic Acid and Mitomycin C in Advanced Gastric Cancer: Results of a Phase II Trial

2000 ◽  
Vol 23 (5) ◽  
pp. 444-447 ◽  
Author(s):  
G. Hartung ◽  
R. Hofheinz ◽  
D. Buchheidt ◽  
A. Rost ◽  
A. Brecht ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Folinic Acid ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Phase Ii ◽  
Phase Ii Trial

A Phase II Trial of 5-Fluorouracil, Leucovorin and Mitomycin C in Patients with Advanced Gastric Cancer

2011 ◽  
Vol 97 (6) ◽  
pp. 698-703
Author(s):  
Sung Rok Kim ◽  
Young Jin Yuh ◽  
Byeong Seok Sohn ◽  
Sung Hyun Yang
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Phase Ii ◽  
Phase Ii Trial

scholarly journals Combination 5-fluorouracil (FU), folinic acid (FA), and α-interferon 2B in advanced gastric cancer: Results of a phase II trial

1995 ◽  
Vol 6 (2) ◽  
pp. 153-156 ◽  
Author(s):  
E. Jäger ◽  
H. Bernhard ◽  
O. Klein ◽  
B. Wächter ◽  
F. Theiss ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Folinic Acid ◽  
Advanced Gastric Cancer ◽  
Phase Ii ◽  
Phase Ii Trial

A phase II trial of paclitaxel and weekly 24 h infusion of 5-fluorouracil/folinic acid in patients with advanced gastric cancer

1997 ◽  
Vol 8 (4) ◽  
pp. 396-399 ◽  
Author(s):  
Carsten Bokemeyer ◽  
Christine S Lampe ◽  
Michael R Clemens ◽  
J??rg T Hartmann ◽  
Detlev Quietzsch ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Folinic Acid ◽  
Advanced Gastric Cancer ◽  
Phase Ii ◽  
Phase Ii Trial

Weekly Infusional High-Dose Fluorouracil (HD-FU), HD-FU Plus Folinic Acid (HD-FU/FA), or HD-FU/FA Plus Biweekly Cisplatin in Advanced Gastric Cancer: Randomized Phase II Trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie

2007 ◽  
Vol 25 (18) ◽  
pp. 2580-2585 ◽  
Author(s):  
Manfred P. Lutz ◽  
Hansjochen Wilke ◽  
D.J. Theo Wagener ◽  
Udo Vanhoefer ◽  
Krzysztof Jeziorski ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Folinic Acid ◽  
Advanced Gastric Cancer ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Progression Free Survival ◽  
Phase Iii ◽  
High Dose ◽  
Phase Iii Trials ◽  
Minimum Number

Purpose This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. Patients and Methods A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Results Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Conclusion Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

High-Dose 5-Fluorouracil / Folinic Acid in Combination with Three-Weekly Mitomycin C in the Treatment of Advanced Gastric Cancer. A Phase II Study

2002 ◽  
Vol 25 (3) ◽  
pp. 255-260 ◽  
Author(s):  
R.-D. Hofheinz ◽  
G. Hartung ◽  
S. Samel ◽  
A. Hochhaus ◽  
U. Pichlmeier ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Folinic Acid ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Phase Ii ◽  
Phase Ii Study ◽  
High Dose
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