Significance of Nitric Oxide and Peroxynitrite in Permeability Changes of the Retinal Microvascular Endothelial Cell Monolayer Induced by Vascular Endothelial Growth Factor

1999 ◽  
Vol 36 (6) ◽  
pp. 510-515 ◽  
Author(s):  
Takeshi Marumo ◽  
Thomas Noll ◽  
Valérie B. Schini-Kerth ◽  
Elizabeth A. Harley ◽  
Jacques Duhault ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Monolayer ◽  
Microvascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Endothelial Cell Monolayer ◽  
Permeability Changes ◽  
Endothelial Growth Factor

Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties

2000 ◽  
Vol 59 (2) ◽  
pp. 265-277 ◽  
Author(s):  
Yong S. Chang ◽  
Lance L. Munn ◽  
Mechteld V. Hillsley ◽  
Randal O. Dull ◽  
Jin Yuan ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Transport Properties ◽  
Cell Monolayer ◽  
Vascular Endothelial ◽  
Endothelial Cell Monolayer ◽  
Endothelial Growth Factor

scholarly journals Vascular endothelial growth factor regulation of Weibel-Palade–body exocytosis

Blood ◽  
2005 ◽  
Vol 105 (1) ◽  
pp. 207-214 ◽  
Author(s):  
Kenji Matsushita ◽  
Munekazu Yamakuchi ◽  
Craig N. Morrell ◽  
Michitaka Ozaki ◽  
Brian O'Rourke ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Vascular Inflammation ◽  
Vascular Endothelial ◽  
Vasoactive Substances ◽  
Oxide Synthase ◽  
Endothelial Growth Factor ◽  
Endothelial Nitric Oxide

Abstract Vascular endothelial growth factor (VEGF) not only regulates angiogenesis, vascular permeability, and vasodilation but also promotes vascular inflammation. However, the molecular basis for the proinflammatory effects of VEGF is not understood. We now show that VEGF activates endothelial cell exocytosis of Weibel-Palade bodies, releasing vasoactive substances capable of causing vascular thrombosis and inflammation. VEGF triggers endothelial exocytosis in part through calcium and phospholipase C-γ (PLC-γ) signal transduction. However, VEGF also modulates endothelial cell exocytosis by activating endothelial nitric oxide synthase (eNOS) production of nitric oxide (NO), which nitrosylates N-ethylmaleimide sensitive factor (NSF) and inhibits exocytosis. Thus, VEGF plays a dual role in regulating endothelial exocytosis, triggering pathways that both promote and inhibit endothelial exocytosis. Regulation of endothelial exocytosis may explain part of the proinflammatory effects of VEGF.

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