Characterization of Endothelium- Dependent Relaxation in Guinea Pig Basilar Artery – Effect of Hypoxia and Role of Cytochrome P450 Mono-Oxygenase

1998 ◽  
Vol 35 (4) ◽  
pp. 285-294 ◽  
Author(s):  
Jesper Petersson ◽  
Peter M. Zygmunt ◽  
Peter Jönsson ◽  
Edward D. Högestätt
Keyword(s):  
Guinea Pig ◽  
Basilar Artery ◽  
Endothelium Dependent Relaxation

Decreased endothelium-dependent relaxation in subarachnoid hemorrhage-induced vasospasm: role of ET-1

1995 ◽  
Vol 269 (3) ◽  
pp. H1009-H1015 ◽  
Author(s):  
M. Zuccarello ◽  
A. Romano ◽  
M. Passalacqua ◽  
R. M. Rapoport
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Receptor Antagonist ◽  
Basilar Artery ◽  
Arterial Blood ◽  
Eta Receptor ◽  
Eta Receptor Antagonist ◽  
Endothelium Dependent Relaxation

The purpose of this study was to test whether endothelium-dependent relaxation is decreased during acute vasospasm following subarachnoid hemorrhage (SAH) and the mechanism underlying the decrease. Basilar artery in situ was 35% constricted 3 days following injection of autologous arterial blood into the rabbit cisterna magna compared with vessels from control rabbits. In situ suffusion with the endothelium-dependent relaxant, acetylcholine (ACh; 10 microM), relaxed resting and serotonin (5-HT)-contracted control vessels but not vasospastic and 5-HT-contracted vasospastic vessels. In contrast, the relaxant potency and efficacy of ACh was similar in control and vasospastic vessels contracted with 5-HT in vitro. In situ suffusion with the ETA-receptor antagonist, BQ-123 (1 microM), reversed the vasospasm by 51% and restored the magnitude of ACh relaxation of vasospastic and 5-HT-contracted vasospastic vessels to that of controls. ACh in situ and in vitro relaxed endothelin-1 (ET-1)-contracted control vessels to a smaller magnitude than 5-HT-contracted control vessels. These results suggest, in contrast to previous studies, that endothelium-dependent relaxation is decreased during acute vasospasm following SAH. The decreased endothelium-dependent relaxation is secondary to the underlying ET-1-mediated spasm. The inhibition of endothelium-dependent relaxation observed in situ following SAH cannot be demonstrated in vitro, presumably due to loss of the ET-1-mediated vasospasm.

Role of NO in endothelium-dependent relaxation of rabbit basilar artery in situ

2000 ◽  
Vol 22 (2) ◽  
pp. 204-208 ◽  
Author(s):  
M. Zuccarello ◽  
R. Boccaletti ◽  
R.M. Rapoport
Keyword(s):  
Basilar Artery ◽  
Endothelium Dependent Relaxation

Characterization of CGRP1 receptors in the guinea pig basilar artery

2001 ◽  
Vol 414 (2-3) ◽  
pp. 249-258 ◽  
Author(s):  
Inger Jansen-Olesen ◽  
Lars Kaarill ◽  
Lars Edvinsson
Keyword(s):  
Guinea Pig ◽  
Basilar Artery
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