Modulation of an Allergic Immune Response via the Mucosal Route in a Murine Model of Inhalative Type–I Allergy

1999 ◽  
Vol 118 (2-4) ◽  
pp. 129-132 ◽  
Author(s):  
U. Wiedermann ◽  
B. Jahn-Schmid ◽  
A. Repa ◽  
D. Kraft ◽  
C. Ebner
Keyword(s):  
Immune Response ◽  
Murine Model ◽  
Type I ◽  
Type I Allergy ◽  
Mucosal Route ◽  
Allergic Immune Response

Formalin-Fixed Staphylococcus aureus Particles Prevent Allergic Sensitization in a Murine Model of Type I Allergy

2007 ◽  
Vol 144 (3) ◽  
pp. 183-196 ◽  
Author(s):  
Karina Gisch ◽  
Nadine Gehrke ◽  
Matthias Bros ◽  
Christina Priesmeyer ◽  
Jürgen Knop ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Murine Model ◽  
Allergic Sensitization ◽  
Type I ◽  
Type I Allergy ◽  
Formalin Fixed

scholarly journals Tolerization of a Type I Allergic Immune Response through Transplantation of Genetically Modified Hematopoietic Stem Cells

2008 ◽  
Vol 180 (12) ◽  
pp. 8168-8175 ◽  
Author(s):  
Ulrike Baranyi ◽  
Birgit Linhart ◽  
Nina Pilat ◽  
Martina Gattringer ◽  
Jessamyn Bagley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Immune Response ◽  
Hematopoietic Stem Cells ◽  
Genetically Modified ◽  
Type I ◽  
Hematopoietic Stem ◽  
Allergic Immune Response

scholarly journals Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy

1999 ◽  
Vol 11 (10) ◽  
pp. 1715-1715 ◽  
Author(s):  
Ursula Wiedermann ◽  
Beatrice Jahn-Schmid ◽  
Marianne Lindblad ◽  
Carola Rask ◽  
Jan Holmgren ◽  
...  
Keyword(s):  
Murine Model ◽  
Type I ◽  
Type I Allergy

scholarly journals Pathogenic Effects of IFIT2 and Interferon-β during Fatal SystemicCandida albicansInfection

mBio ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. e00365-18 ◽  
Author(s):  
Marcin Stawowczyk ◽  
Shamoon Naseem ◽  
Valeria Montoya ◽  
Darren P. Baker ◽  
James Konopka ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Nadph Oxidase ◽  
Murine Model ◽  
Viral Infections ◽  
Attributable Mortality ◽  
Type I ◽  
Content Type ◽  
Innate Defense ◽  
Gene Coding

ABSTRACTA balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense. Interferons (IFNs) are critical mediators of the innate defense to infection, and in this study we evaluated the contribution of a specific gene coding for IFIT2 induced by type I IFNs in a murine model of disseminatedCandida albicans. Invasive candidiasis is a frequent challenge during immunosuppression or surgical medical interventions, andC. albicansis a common culprit that leads to high rates of mortality. When IFIT2 knockout mice were infected systemically withC. albicans, they were found to have improved survival and reduced fungal burden compared to wild-type mice. One of the mechanisms by which IFIT2 increases the pathological effects of invasiveC. albicansappears to be suppression of NADPH oxidase activation. Loss of IFIT2 increases production of reactive oxygen species by leukocytes, and we demonstrate that IFIT2 is a binding partner of a critical regulatory subunit of NADPH oxidase, p67phox. Since the administration of IFN has been used therapeutically to combat viral infections, cancer, and multiple sclerosis, we evaluated administration of IFN-β to mice prior toC. albicansinfection. IFN-β treatment promoted pathology and death fromC. albicansinfection. We provide evidence that IFIT2 increases the pathological effects of invasiveC. albicansand that administration of IFN-β has deleterious effects during infection.IMPORTANCEThe attributable mortality associated with systemicC. albicansinfections in health care settings is significant, with estimates greater than 40%. This life-threatening disease is common in patients with weakened immune systems, either due to disease or as a result of therapies. Type I interferons (IFN) are cytokines of the innate defense response that are used as immune modulators in the treatment of specific cancers, viral infections, and multiple sclerosis. In this study, we show using a murine model that the loss of a specific IFN-stimulated gene coding for IFIT2 improves survival following systemicC. albicansinfection. This result infers a harmful effect of IFN duringC. albicansinfection and is supported by our finding that administration of IFN-β prior to invasive infection promotes fatal pathology. The findings contribute to our understanding of the innate immune response toC. albicans, and they suggest that IFN therapies present a risk factor for disseminated candidiasis.

scholarly journals 9-cis retinoic acid modulates the type I allergic immune response

2018 ◽  
Vol 141 (2) ◽  
pp. 650-658.e5 ◽  
Author(s):  
Guido Heine ◽  
Tim Hollstein ◽  
Sandra Treptow ◽  
Andreas Radbruch ◽  
Margitta Worm
Keyword(s):  
Immune Response ◽  
Retinoic Acid ◽  
Type I ◽  
Allergic Immune Response

Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy

1999 ◽  
Vol 11 (10) ◽  
pp. 1717-1724 ◽  
Author(s):  
Ursula Wiedermann ◽  
Beatrice Jahn-Schmid ◽  
Marianne Lindblad ◽  
Carola Rask ◽  
Jan Holmgren ◽  
...  
Keyword(s):  
Murine Model ◽  
Type I ◽  
Type I Allergy

scholarly journals Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy

1999 ◽  
Vol 11 (7) ◽  
pp. 1131-1138 ◽  
Author(s):  
Ursula Wiedermann ◽  
Beatrice Jahn-Schmid ◽  
Marianne Lindblad ◽  
Carola Rask ◽  
Jan Holmgren ◽  
...  
Keyword(s):  
Murine Model ◽  
Type I ◽  
Type I Allergy

Long-Term Tolerance in a Murine Model of Type I Allergy Through Transplantation of Genetically Modified Hematopoietic Stem Cells

2007 ◽  
Vol 123 ◽  
pp. S77
Author(s):  
Ulrike Baranyi ◽  
Birgit Linhart ◽  
Nina Pilat ◽  
John Iacomini ◽  
Jessamyn Bagely ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Murine Model ◽  
Genetically Modified ◽  
Type I ◽  
Hematopoietic Stem ◽  
Type I Allergy
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