Inhibition of Guinea Pig Skin Allergic Reactions by Nonpeptide Bradykinin B2 Receptor Antagonist FR173657

1998 ◽  
Vol 116 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Takeshi Mori ◽  
Takahisa Imamura
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Allergic Reactions ◽  
Pig Skin

Inhibitory effects of clonidine on allergic reactions in guinea-pig skin

1987 ◽  
Vol 134 (3) ◽  
pp. 339-343 ◽  
Author(s):  
Björn R. Lindgren ◽  
Chris D. Anderson ◽  
Thomas Frödin ◽  
Rolf G.G. Andersson
Keyword(s):  
Guinea Pig ◽  
Allergic Reactions ◽  
Inhibitory Effects ◽  
Pig Skin

scholarly journals THE SPECIFICITY OF ALLERGIC REACTIONS

1961 ◽  
Vol 114 (2) ◽  
pp. 185-194 ◽  
Author(s):  
S. B. Salvin ◽  
R. F. Smith
Keyword(s):  
Guinea Pig ◽  
Intradermal Injection ◽  
Contact Hypersensitivity ◽  
Allergic Reactions ◽  
Oil Emulsion ◽  
Pig Skin ◽  
Intradermal Administration ◽  
Water In Oil Emulsion ◽  
Circulating Antibody ◽  
Pig Serum

Intradermal injection of a simple hapten (e.g., 1-fluoro-2,4-dinitrobenzene) in water-in-oil emulsion results in contact hypersensitivity to surface application of the homologous hapten and, after appearance of circulating antibody, in Arthus type hypersensitivity to a conjugate of homologous hapten with guinea pig serum. Intradermal administration of this conjugate induces delayed and subsequently Arthus hypersensitivity to the conjugate, but no evidence of a contact reaction to the hapten alone. When a conjugate of hapten plus solubilized guinea pig skin is used as the sensitizing antigen, both contact hypersensitivity to the hapten and delayed and/or Arthus reactions to the conjugate develop. These observations are consistent with the hypothesis that the specificity of contact sensitivity is directed toward some particular protein of the skin which has been modified by combination with hapten.

scholarly journals Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis

1971 ◽  
Vol 12 (3) ◽  
pp. 347-360
Author(s):  
VICTOR R. WHEATLEY ◽  
LEONARD T. HODGINS ◽  
WILLIAM M. COON ◽  
MUTUKUMARA KUMARASIRI ◽  
HAROLD BERENZWEIG ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Lipid Synthesis ◽  
Pig Skin

Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics

2010 ◽  
Vol 29 (6_suppl) ◽  
pp. 244S-273S ◽  
Author(s):  
Christina L. Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Safety Assessment ◽  
Expert Panel ◽  
Kojic Acid ◽  
Tumor Promotion ◽  
Final Report ◽  
Cosmetic Products ◽  
Pig Skin ◽  
Animal Data ◽  
Skin Lightening

Kojic acid functions as an antioxidant in cosmetic products. Kojic acid was not a toxicant in acute, chronic, reproductive, and genotoxicity studies. While some animal data suggested tumor promotion and weak carcinogenicity, kojic acid is slowly absorbed into the circulation from human skin and likely would not reach the threshold at which these effects were seen. The available human sensitization data supported the safety of kojic acid at a use concentration of 2% in leave-on cosmetics. Kojic acid depigmented black guinea pig skin at a concentration of 4%, but this effect was not seen at 1%. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the 2 end points of concern, dermal sensitization and skin lightening, would not be seen at use concentrations below 1%; therefore, this ingredient is safe for use in cosmetic products up to that level.

Phospholipids (PL) in the Arthus reaction sites induced in guinea-pig skin

1994 ◽  
Vol 8 (1) ◽  
pp. 84
Author(s):  
T. Tachibana ◽  
S. Taniguchi ◽  
S. Imamura
Keyword(s):  
Guinea Pig ◽  
Arthus Reaction ◽  
Pig Skin
Sign in / Sign up

Export Citation Format

Share Document