Increased Urinary Excretion of Collagen Crosslinks in Type 1 Diabetic Children in the First 5 Years of Disease

1999 ◽  
Vol 51 (4) ◽  
pp. 173-177 ◽  
Author(s):  
G. Valerio ◽  
A. Franzese ◽  
A. Esposito-Del Puente ◽  
S. Formicola ◽  
S. Di Maio ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Collagen Crosslinks ◽  
Diabetic Children

Personalized Hybrid Models for Exercise, Meal, and Insulin Interventions in Type 1 Diabetic Children and Adolescents

2013 ◽  
Vol 52 (36) ◽  
pp. 13020-13033 ◽  
Author(s):  
Naviyn Prabhu Balakrishnan ◽  
Lakshminarayanan Samavedham ◽  
Gade Pandu Rangaiah
Keyword(s):  
Children And Adolescents ◽  
Hybrid Models ◽  
Diabetic Children

Insulin sensitivity in Type 1 diabetic children and adolescents

2008 ◽  
Vol 25 (3) ◽  
pp. 282-288 ◽  
Author(s):  
A. Szadkowska ◽  
I. Pietrzak ◽  
B. Mianowska ◽  
J. Bodalska-Lipińska ◽  
H. A. Keenan ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Children And Adolescents ◽  
Diabetic Children

scholarly journals Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension

2008 ◽  
Vol 36 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Yong Liu ◽  
Ravinder J. Singh ◽  
Kristie Usa ◽  
Brian C. Netzel ◽  
Mingyu Liang
Keyword(s):  
Blood Pressure ◽  
Urinary Excretion ◽  
Molecular Mechanisms ◽  
Renal Medulla ◽  
Hydroxysteroid Dehydrogenase ◽  
Induced Hypertension ◽  
Intensive Investigation ◽  
Salt Sensitive Hypertension ◽  
Interfering Rna

The Dahl salt-sensitive rat is a widely used model of human salt-sensitive forms of hypertension. The kidney plays an important role in the pathogenesis of Dahl salt-sensitive hypertension, but the molecular mechanisms involved remain a subject of intensive investigation. Gene expression profiling studies suggested that 11β-hydroxysteroid dehydrogenase type 1 might be dysregulated in the renal medulla of Dahl salt-sensitive rats. Additional analysis confirmed that renal medullary expression of 11β-hydroxysteroid dehydrogenase type 1 was downregulated by a high-salt diet in SS-13BN rats, a consomic rat strain with reduced blood pressure salt sensitivity, but not in Dahl salt-sensitive rats. 11β-Hydroxysteroid dehydrogenase type 1 is known to convert inactive 11-dehydrocorticosterone to active corticosterone. The urinary corticosterone/11-dehydrocorticosterone ratio as well as urinary excretion of corticosterone was higher in Dahl salt-sensitive rats than in SS-13BN rats. Knockdown of renal medullary 11β-hydroxysteroid dehydrogenase type 1 with small-interfering RNA attenuated the early phase of salt-induced hypertension in Dahl salt-sensitive rats and reduced urinary excretion of corticosterone. Knockdown of 11β-hydroxysteroid dehydrogenase type 1 did not affect blood pressure in SS-13BN rats. Long-term attenuation of salt-induced hypertension was achieved with small hairpin RNA targeting renal medullary 11β-hydroxysteroid dehydrogenase type 1. In summary, we have demonstrated that suppression of 11β-hydroxysteroid dehydrogenase type 1 expression in the renal medulla attenuates salt-induced hypertension in Dahl salt-sensitive rats.

Body Composition Changes in Newly Diagnosed Type 1 Diabetic Children.

2010 ◽  
pp. P3-541-P3-541
Author(s):  
NS Sattar ◽  
K Tafuri ◽  
J Osipoff ◽  
TA Wilson ◽  
AH Lane
Keyword(s):  
Body Composition ◽  
Newly Diagnosed ◽  
Diabetic Children ◽  
Composition Changes

scholarly journals Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus

2011 ◽  
Vol 14 (4) ◽  
pp. 29-31 ◽  
Author(s):  
Irina Arkad'evna Bondar' ◽  
Vadim Valer'evich Klimontov ◽  
Ekaterina Mikhailovna Parfent'eva ◽  
Vyacheslav Vital'evich Romanov ◽  
Alexander Petrovich Nadeev
Keyword(s):  
Type 1 Diabetes ◽  
Urinary Excretion ◽  
Renal Fibrosis ◽  
Type Iv Collagen ◽  
Diagnostic Value ◽  
Control Group ◽  
Type Iv ◽  
Patients With Diabetes

Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes.

scholarly journals PO-0052 Nitric Oxide, Immunoglobulins And Lipid Peroxidation In Type 1 Diabetic Children

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A267.1-A267
Author(s):  
M Smahi ◽  
M Aribi ◽  
L Ysmaildahlok ◽  
L Hamouda ◽  
W Meziane
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Diabetic Children
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