Glucose Tolerance and Insulin Secretion in Children before and during Recombinant Growth Hormone Treatment

1998 ◽  
Vol 50 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Guido Filler ◽  
Peter Amendt ◽  
Klaus-Dieter Kohnert ◽  
Siegmar Devaux ◽  
Jochen H.H. Ehrich
Keyword(s):  
Growth Hormone ◽  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Recombinant Growth Hormone

Long-Term Mortality after Recombinant Growth Hormone Treatment for Isolated Childhood Short Stature: Report of the French SAGhE Study

2011 ◽  
pp. LB-5-LB-5 ◽  
Author(s):  
Jean-Claude Carel ◽  
Emmanuel Ecosse ◽  
Fabienne Landier ◽  
Djamila Meguellati-Hakkas ◽  
Florentia Kaguelidou ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Recombinant Growth Hormone ◽  
Long Term Mortality

Effect of growth hormone treatment on insulin secretion and glucose metabolism in prepubertal boys with short stature

1994 ◽  
Vol 131 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Jan Åman ◽  
Sten Rosberg ◽  
Kerstin Albertsson-Wikland
Keyword(s):  
Growth Hormone ◽  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Growth Hormone Treatment ◽  
Gh Deficiency ◽  
Hormone Treatment ◽  
Glucose Disposal ◽  
First Year ◽  
Gh Treatment ◽  
Prepubertal Boys

Aman J. Rosberg S, Albertsson-Wikland K. Effect of growth hormone treatment on insulin secretion and glucose metabolism in prepubertal boys with short stature. Eur Endocrinol 1994;131:246–50. ISSN 0804–4643 The purpose of this study was to evaluate the effect on insulin secretion and glucose metabolism of daily growth hormone (GH) treatment, 0.1 U/kg. for up to 3 years in 42 short prepubertal boys without GH deficiency. Their median height standard deviation (sd) score increased from −2.7 to −1.7, whereas their weight for height sd score was unchanged after 3 years of treatment. Fasting plasma glucose concentrations were unchanged, but median fasting insulin concentrations increased from 6.0 mU/l before treatment to 7.8 mU/l (p < 0.05) after the first year. No further increase was seen during the second or third years. The median insulin area under the curve 10–60 min after an intravenous glucose tolerance test increased from 480 mU·1−1·min−1 before treatment to 799 mU·1−1 · min−1 (p < 0.05) after 1 year. The median glucose disposal rate (K value) before GH treatment, 2.2%/min, was unchanged after 1 year of treatment. A significant positive correlation was found between the change in the height sd score and the change in fasting insulin concentration during the first (r = 0.45; p < 0.01) and second (r = 0.56; p < 0.05) years of GH treatment. It was concluded that GH treatment in prepubertal children without GH deficiency caused a moderate increase in fasting and stimulated insulin concentrations during the first year of treatment. There was no further change during the following years of treatment, and there were no negative effects on fasting plasma glucose concentrations or glucose disposal rates. The increase in insulin concentration was related positively to the growth response. Jan Åman, Department of Pediatrics, Örebro Medical Centre Hospital, S-701 85 Örebro, Sweden

scholarly journals In vivo Investigations of the Effect of Short- and Long-Term Recombinant Growth Hormone Treatment on DNA-Methylation in Humans

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120463 ◽  
Author(s):  
Julia Kolarova ◽  
Ole Ammerpohl ◽  
Jana Gutwein ◽  
Maik Welzel ◽  
Inka Baus ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Recombinant Growth Hormone ◽  
Short And Long Term

scholarly journals A Study of Chromosomal Aberrations and Chromosomal Fragility after Recombinant Growth Hormone Treatment

2000 ◽  
Vol 47 (5) ◽  
pp. 634-639 ◽  
Author(s):  
Arnold H Slyper ◽  
Jeffrey D Shadley ◽  
Peter Van Tuinen ◽  
Samuel M Richton ◽  
Raymond G Hoffmann ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Chromosomal Aberrations ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Recombinant Growth Hormone ◽  
Chromosomal Fragility
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