Linkage Analysis of Quantitative Trait Loci: Sib Pairs or Sibships?

2000 ◽  
Vol 50 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Alexandre Alcaïs ◽  
Laurent Abel
Keyword(s):  
Quantitative Trait Loci ◽  
Linkage Analysis ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Sib Pairs

scholarly journals Using Linkage Analysis to Identify Quantitative Trait Loci for Sleep Apnea in Relationship to Body Mass Index

2008 ◽  
Vol 72 (6) ◽  
pp. 762-773 ◽  
Author(s):  
E. K. Larkin ◽  
S. R. Patel ◽  
R. C. Elston ◽  
C. Gray-McGuire ◽  
X. Zhu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Sleep Apnea ◽  
Quantitative Trait Loci ◽  
Linkage Analysis ◽  
Body Mass ◽  
Quantitative Trait ◽  
Trait Loci

Joint Linkage and Linkage Disequilibrium Mapping of Quantitative Trait Loci in Natural Populations

Genetics ◽  
2002 ◽  
Vol 160 (2) ◽  
pp. 779-792 ◽  
Author(s):  
Rongling Wu ◽  
Chang-Xing Ma ◽  
George Casella
Keyword(s):  
Linkage Disequilibrium ◽  
Quantitative Trait Loci ◽  
Linkage Analysis ◽  
Quantitative Trait ◽  
Genome Mapping ◽  
Linkage Disequilibrium Mapping ◽  
Allelic Association ◽  
Mapping Strategy ◽  
Trait Loci ◽  
New Strategy

AbstractLinkage analysis and allelic association (also referred to as linkage disequilibrium) studies are two major approaches for mapping genes that control simple or complex traits in plants, animals, and humans. But these two approaches have limited utility when used alone, because they use only part of the information that is available for a mapping population. More recently, a new mapping strategy has been designed to integrate the advantages of linkage analysis and linkage disequilibrium analysis for genome mapping in outcrossing populations. The new strategy makes use of a random sample from a panmictic population and the open-pollinated progeny of the sample. In this article, we extend the new strategy to map quantitative trait loci (QTL), using molecular markers within the EM-implemented maximum-likelihood framework. The most significant advantage of this extension is that both linkage and linkage disequilibrium between a marker and QTL can be estimated simultaneously, thus increasing the efficiency and effectiveness of genome mapping for recalcitrant outcrossing species. Simulation studies are performed to test the statistical properties of the MLEs of genetic and genomic parameters including QTL allele frequency, QTL effects, QTL position, and the linkage disequilibrium of the QTL and a marker. The potential utility of our mapping strategy is discussed.

Efficiency Robust Tests for Mapping Quantitative Trait Loci Using Extremely Discordant Sib Pairs

2003 ◽  
Vol 55 (2-3) ◽  
pp. 117-124 ◽  
Author(s):  
Boris Freidlin ◽  
Gang Zheng ◽  
Zhaohai Li ◽  
Joseph L. Gastwirth
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Robust Tests ◽  
Sib Pairs

scholarly journals Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

Twin Research ◽  
2003 ◽  
Vol 6 (4) ◽  
pp. 322-324 ◽  
Author(s):  
Marian Beekman ◽  
Bastiaan T. Heijmans ◽  
Nicholas G. Martin ◽  
John B. Whitfield ◽  
Nancy L. Pedersen ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Linkage Analysis ◽  
Quantitative Trait ◽  
Lipoprotein A ◽  
Trait Loci
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