Frequencies of Fetal Nucleated Red Blood Cells in Maternal Blood during Different Stages of Gestation

1998 ◽  
Vol 13 (6) ◽  
pp. 375-379 ◽  
Author(s):  
Pao-Lin Kuo
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells

scholarly journals A Silicon-based Coral-like Nanostructured Microfluidics to Isolate Rare Cells in Human Circulation: Validation by SK-BR-3 Cancer Cell Line and Its Utility in Circulating Fetal Nucleated Red Blood Cells

Micromachines ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 132 ◽  
Author(s):  
Gwo-Chin Ma ◽  
Wen-Hsiang Lin ◽  
Chung-Er Huang ◽  
Ting-Yu Chang ◽  
Jia-Yun Liu ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Pregnant Women ◽  
Blood Cells ◽  
De Novo ◽  
Capture Rate ◽  
Genetic Diagnosis ◽  
Maternal Blood ◽  
Capture Efficiency ◽  
Nucleated Red Blood Cells ◽  
Silicon Based

Circulating fetal cells (CFCs) in maternal blood are rare but have a strong potential to be the target for noninvasive prenatal diagnosis (NIPD). “Cell RevealTM system” is a silicon-based microfluidic platform capable to capture rare cell populations in human circulation. The platform is recently optimized to enhance the capture efficiency and system automation. In this study, spiking tests of SK-BR-3 breast cancer cells were used for the evaluation of capture efficiency. Then, peripheral bloods from 14 pregnant women whose fetuses have evidenced non-maternal genomic markers (e.g., de novo pathogenic copy number changes) were tested for the capture of circulating fetal nucleated red blood cells (fnRBCs). Captured cells were subjected to fluorescent in situ hybridization (FISH) on chip or recovered by an automated cell picker for molecular genetic analyses. The capture rate for the spiking tests is estimated as 88.1%. For the prenatal study, 2–71 fnRBCs were successfully captured from 2 mL of maternal blood in all pregnant women. The captured fnRBCs were verified to be from fetal origin. Our results demonstrated that the Cell RevealTM system has a high capture efficiency and can be used for fnRBC capture that is feasible for the genetic diagnosis of fetuses without invasive procedures.

Isolation of fetal nucleated red blood cells from maternal blood

2000 ◽  
Vol 20 (2) ◽  
pp. 169-171 ◽  
Author(s):  
Zou Li ◽  
Ye Xiaojing ◽  
Xu Keshu ◽  
Zhu Jianwen
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells

Fetal nucleated red blood cells in maternal blood: A potential marker for preterm deliveries?

2000 ◽  
Vol 70 ◽  
pp. B71-B71
Author(s):  
I. Hoesli ◽  
W. Holzgreve ◽  
M. Danek ◽  
C.J. Li ◽  
E. Daly-Grandeau ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells ◽  
Potential Marker

scholarly journals Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

2020 ◽  
Vol 34 (9) ◽  
Author(s):  
Dragos Nemescu ◽  
Daniela Constantinescu ◽  
Vlad Gorduza ◽  
Alexandru Carauleanu ◽  
Lavinia Caba ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Cell Sorting ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells ◽  
Magnetic Activated Cell Sorting

Frequency of nucleated red blood cells in maternal blood during the different gestational ages

1998 ◽  
Vol 103 (6) ◽  
pp. 723-726 ◽  
Author(s):  
L. P. Shulman ◽  
Owen P. Phillips ◽  
Elizabeth Tolley ◽  
David Sammons ◽  
S. S. Wachtel
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells

Spectroscopic and Fluorescence Microscopy for Isolating Fetal Nucleated Red Blood Cells from Maternal Blood

2013 ◽  
Author(s):  
Vladimir Turzhitsky ◽  
Lianyu Guo ◽  
Le Qiu ◽  
Alla Turshudzhyan ◽  
Edward Vitkin ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Maternal Blood ◽  
Nucleated Red Blood Cells
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