Regeneration Processes in the Kidney after Acute Injury: Role of Infiltrating Cells

1998 ◽  
Vol 6 (6) ◽  
pp. 502-507 ◽  
Author(s):  
Manuela Ghielli ◽  
Walter A Verstrepen ◽  
Etienne J. Nouwen ◽  
Marc E. De Broe
Keyword(s):  
Acute Injury ◽  
Infiltrating Cells ◽  
Regeneration Processes

ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

2018 ◽  
pp. 32-37 ◽  
Author(s):  
Z. A. Shafigullina ◽  
S. Yu. Medvedeva ◽  
I. G. Danilova
Keyword(s):  
Toxic Hepatitis ◽  
Intraperitoneal Administration ◽  
Sharp Decrease ◽  
Cellular Component ◽  
Ki 67 ◽  
Sinusoidal Cells ◽  
Toxic Damage ◽  
Stromal Component ◽  
Regeneration Processes

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells

2021 ◽  
Author(s):  
Ana M. Giménez-Arnau ◽  
Laurence DeMontojoye ◽  
Riccardo Asero ◽  
Massimo Cugno ◽  
Kanokvalai Kulthanan ◽  
...  
Keyword(s):  
Chronic Spontaneous Urticaria ◽  
Infiltrating Cells

scholarly journals Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3

2002 ◽  
Vol 39 (8) ◽  
pp. 1399-1403 ◽  
Author(s):  
Yoshinori Seko ◽  
Nobuhiko Kayagaki ◽  
Ken-ichiro Seino ◽  
Hideo Yagita ◽  
K.o Okumura ◽  
...  
Keyword(s):  
Acute Myocarditis ◽  
Coxsackievirus B3 ◽  
Infiltrating Cells

scholarly journals Role of PDGF B-Chain and PDGF Receptors in Rat Tubular Regeneration after Acute Injury

1999 ◽  
Vol 155 (5) ◽  
pp. 1689-1699 ◽  
Author(s):  
Takahiko Nakagawa ◽  
Masakiyo Sasahara ◽  
Masakazu Haneda ◽  
Hideo Kataoka ◽  
Hiroko Nakagawa ◽  
...  
Keyword(s):  
Acute Injury

Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes

2013 ◽  
Vol 454 (1) ◽  
pp. 133-145 ◽  
Author(s):  
Satomi Nadanaka ◽  
Shoji Kagiyama ◽  
Hiroshi Kitagawa
Keyword(s):  
Liver Injury ◽  
Knockout Mice ◽  
Weight Ratio ◽  
Hepatocyte Proliferation ◽  
Chain Elongation ◽  
Wild Type ◽  
Ccl4 Administration ◽  
Ccl4 Treatment ◽  
Regeneration Processes

The gene products of two members of the EXT (exostosin) gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate. EXTL2 (EXT-like 2), one of the three EXTL genes in the human genome that are homologous to EXT1 and EXT2, encodes an N-acetylhexosaminyltransferase. We have demonstrated that EXTL2 terminates chain elongation of GAGs (glycosaminoglycans), and thereby regulates GAG biosynthesis. The abnormal GAG biosynthesis caused by loss of EXTL2 had no effect on normal development or normal adult homoeostasis. Therefore we examined the role of EXTL2 in CCl4 (carbon tetrachloride)-induced liver failure, a model of liver disease. On the fifth day after CCl4 administration, the liver/body weight ratio was significantly smaller for EXTL2-knockout mice than for wild-type mice. Consistent with this observation, hepatocyte proliferation following CCl4 treatment was lower in EXTL2-knockout mice than in wild-type mice. EXTL2-knockout mice experienced less HGF (hepatocyte growth factor)-mediated signalling than wild-type mice specifically because GAG synthesis was altered in these mutant mice. In addition, GAG synthesis in hepatic stellate cells was up-regulated during liver repair in EXTL2-knockout mice. Taken together, the results of the present study indicated that EXTL2-mediated regulation of GAG synthesis was important to the tissue regeneration processes that follow liver injury.

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