The Nitric Oxide Synthase/ Nitric Oxide and Heme Oxygenase/ Carbon Monoxide Pathways in the Human Ureter

1998 ◽  
Vol 33 (2) ◽  
pp. 214-221 ◽  
Author(s):  
C.E. Iselin ◽  
L. Ny ◽  
B. Larsson ◽  
N.C. Schaad ◽  
P. Alm ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Oxide Synthase ◽  
Human Ureter

Contribution of the Heme Oxygenase Pathway to the Maintenance of the Hypothalamic Blood Flow during Diminished Nitric Oxide Synthesis

2003 ◽  
Vol 23 (6) ◽  
pp. 653-657 ◽  
Author(s):  
Béla Horváth ◽  
András Hrabák ◽  
Krisztina Káldi ◽  
Péter Sándor ◽  
Zoltán Benyó
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Intraperitoneal Administration ◽  
Nitric Oxide Synthesis ◽  
Oxide Synthase ◽  
Pharmacologic Inhibition

The cerebrovascular effects of the heme oxygenase–carbon monoxide pathway were studied in the rat hypothalamus. Intraperitoneal administration of the heme oxygenase inhibitor zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG, 45 μmol/kg) had no significant effect on the resting cerebral blood flow, but increased hypothalamic nitric oxide synthase activity by 67% without changing the CSF cyclic GMP concentration. After pharmacologic inhibition of nitric oxide synthase, the diminished cerebral blood flow was further reduced by 22% after administration of ZnDPBG, and the effect showed direct correlation with the baseline perfusion level. Therefore, endogenous carbon monoxide may significantly contribute to the cerebral vasoregulation under resting conditions and in pathophysiologic states associated with diminished nitric oxide synthesis.

scholarly journals Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 ◽  
Vol 89 (23) ◽  
pp. 11141-11145 ◽  
Author(s):  
K. McMillan ◽  
D. S. Bredt ◽  
D. J. Hirsch ◽  
S. H. Snyder ◽  
J. E. Clark ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase

Interrelation between nitric oxide synthase and heme oxygenase in rat endothelial cells

1997 ◽  
Vol 331 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Toshirou Seki ◽  
Mitsuhide Naruse ◽  
Kiyoko Naruse ◽  
Takanobu Yoshimoto ◽  
Akiyo Tanabe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Oxide Synthase

Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase

2000 ◽  
Vol 278 (1) ◽  
pp. G148-G155 ◽  
Author(s):  
Raman Battish ◽  
Gao-Yuan Cao ◽  
Richard B. Lynn ◽  
Sushanta Chakder ◽  
Satish Rattan
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Anal Verge ◽  
Neuronal Cell ◽  
Neuronal Nitric Oxide Synthase ◽  
High Rate ◽  
Neuronal Cell Bodies ◽  
Oxide Synthase ◽  
Messenger Molecule

Recent investigations have suggested carbon monoxide (CO) as a putative messenger molecule. Although several studies have implicated the heme oxygenase (HO) pathway, responsible for the endogenous production of CO, in the neuromodulatory control of the internal anal sphincter (IAS), its exact role is not known. Nitric oxide, produced by neuronal nitric oxide synthase (nNOS) of myenteric neurons, is an important inhibitory neural messenger molecule mediating nonadrenergic noncholinergic (NANC) relaxation of the IAS. The present studies were undertaken to investigate in detail the presence and coexistence of heme oxygenase-2 (HO-2) with nNOS in the opossum anorectum. In perfusion-fixed, frozen-sectioned tissue, HO-2 immunoreactive (IR) and nNOS IR nerves were identified using immunocytochemistry. Ganglia containing HO-2 IR neuronal cell bodies were present in the myenteric and submucosal plexuses throughout the entire anorectum. Colocalization of HO-2 IR and nNOS IR was nearly 100% in the IAS and decreased proximally from the anal verge. In the rectum, colocalization of HO-2 IR and nNOS IR was ∼70%. Additional confocal microscopy studies using c-Kit staining demonstrated the localization of HO-2 IR and nNOS IR in interstitial cells of Cajal (ICC) of the anorectum. From the high rate of colocalization of HO-2 IR and nNOS IR in the IAS as well as the localization of HO-2 IR and nNOS IR in ICC in conjunction with earlier studies of the HO pathway, we speculate an interaction between HO and NOS pathways in the NANC inhibitory neurotransmission of the IAS and rectum.

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