scholarly journals NIH Consensus Panel Recommends Expanding Access to and Improving Methadone Treatment Programs for Heroin Addiction

1999 ◽  
Vol 5 (1) ◽  
pp. 50-51 ◽  
Keyword(s):  
Methadone Treatment ◽  
Heroin Addiction ◽  
Treatment Programs ◽  
Consensus Panel

Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment

2021 ◽  
Author(s):  
Xiaohu Xie ◽  
Jun Gu ◽  
Dingding Zhuang ◽  
Xiaoyu Chen ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Treatment Response ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Heroin Addiction ◽  
High Dose ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Delta Subunit

Aim: This study determined if gene variants in the GABA receptor delta subunit ( GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in GABRD were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT. Results: No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders. Conclusion: The results indicated that GABRD variants may play a small role in modulating methadone treatment response.

Pharmacogenetic study of methadone treatment for heroin addiction

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yen-Jung Chen ◽  
Ju-Ting Lu ◽  
Chun-Wei Huang ◽  
Wei-Hsin Wu ◽  
Kuei-Fang Lee ◽  
...  
Keyword(s):  
Methadone Treatment ◽  
Heroin Addiction ◽  
Pharmacogenetic Study

scholarly journals Perpetration of Intimate Partner Violence Among Men in Methadone Treatment Programs in New York City

2007 ◽  
Vol 97 (7) ◽  
pp. 1230-1232 ◽  
Author(s):  
Nabila El-Bassel ◽  
Louisa Gilbert ◽  
Elwin Wu ◽  
Mingway Chang ◽  
Jorge Fontdevila
Keyword(s):  
New York ◽  
New York City ◽  
Intimate Partner Violence ◽  
York City ◽  
Partner Violence ◽  
Methadone Treatment ◽  
Intimate Partner ◽  
Treatment Programs

Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts: A Randomized Controlled Trial

2014 ◽  
Vol 42 (03) ◽  
pp. 569-586 ◽  
Author(s):  
Yuan-Yu Chan ◽  
Wan-Yu Lo ◽  
Tsai-Chung Li ◽  
Lih-Jong Shen ◽  
Szu-Nian Yang ◽  
...  
Keyword(s):  
Methadone Maintenance ◽  
Short Form ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Methadone Treatment ◽  
Sham Acupuncture ◽  
Opiate Dependence ◽  
Heroin Addiction ◽  
Daily Consumption ◽  
Heroin Addicts

Scant scientific evidence supports the efficacy of acupuncture in the treatment of opiate dependence. The purpose of this study was to examine the effectiveness of acupuncture for heroin addicts on methadone maintenance by measuring the daily consumption of methadone, variations in the 36-item Short Form Health Survey-36 (SF-36) and Pittsburgh Sleep Quality Index (PSQI) scores, and heroin craving. Sixty heroin addicts were randomly assigned to true acupuncture (electroacupuncture at the Hegu [LI4] and Zusanli [ST36] acupoints, as well as acupuncture at the Ear Shenmen) or sham acupuncture (minimal acupuncture at the Hegu and Zusanli acupoints without electrical stimulation and superficial acupuncture at the Ear Shenmen), twice weekly for 4 weeks. From week 2 onwards, the daily dose of methadone was reduced by a significantly greater amount with true acupuncture compared with sham acupuncture. True acupuncture was also associated with a greater improvement in sleep latency at follow-up. All adverse events were mild in severity. Acupuncture appears to be a useful adjunct to methadone maintenance therapy (MMT) in heroin addiction.

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