Oral Lichenoid Lesions after Thalidomide Treatment

Dermatology ◽  
1999 ◽  
Vol 199 (2) ◽  
pp. 195-195 ◽  
Author(s):  
C. Bez ◽  
G. Lodi ◽  
A. Sardella ◽  
A. Della Volpe ◽  
A. Carrassi
2021 ◽  
Vol 8 (2) ◽  
pp. 84-88
Author(s):  
Marwa Zohdy ◽  
Simone Cazzaniga ◽  
Helga Nievergelt ◽  
Roland Blum ◽  
Valérie G. A. Suter ◽  
...  

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) can both present with histological dysplasia. Despite the presence of WHO-defined criteria for the evaluation of epithelial dysplasia, its assessment is frequently subjective (inter-observer variability). The lack of reproducibility in the evaluation of dysplasia is even more complex in the presence of a lichenoid inflammation. We evaluated dysplasia in 112 oral biopsies with lichenoid inflammation in order to study the inter-observer and the intra-observer variability.


2021 ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Risa Shimizu ◽  
Hiroyuki Harada

Oral Oncology ◽  
2021 ◽  
Vol 117 ◽  
pp. 105282
Author(s):  
Miguel Ángel González-Moles ◽  
Pablo Ramos-García ◽  
Saman Warnakulasuriya

2020 ◽  
Vol 7 (2) ◽  
pp. 18-25
Author(s):  
Alexandre Perez ◽  
Benjamin Lazzarotto ◽  
Jean-Pierre Carrel ◽  
Tommaso Lombardi

Background: Lichen planus is a chronic mucocutaneous inflammatory disease. Oral manifestations are common, and may remain exclusive to the oral mucosa without involvement of the skin or other mucosae. A differential diagnosis includes oral lichenoid drug reactions. Allopurinol, which is the first line hypo-uricemic treatment, is often quoted as being a possible offending drug, though oral reactions have rarely been reported. Case presentation: We describe a 59-year-old male gout patient, successfully treated with allopurinol, who developed acute onset of oral lichenoid lesions, involving bilaterally the buccal mucosa, the tongue and the labial mucosa. Histopathology was consistent with a lichen planus or a drug-induced lichenoid reaction. Improvement of the patient’s condition after withdrawal of allopurinol confirmed the lichenoid nature of the lesion. Remission was complete after a few weeks. Discussion: Although unusual, allopurinol may induce a lichenoid drug reaction. These reactions may mimic clinically and histopathologically idiopathic lichen planus. Improvement or complete regression of the lesions may be attempted to confirm the diagnosis. According to the latest WHO recommendations, these lesions have a potential for malignant transformation.


2006 ◽  
Vol 77 (5) ◽  
pp. 453-454 ◽  
Author(s):  
Patrizia Zappasodi ◽  
Silvia Mangiacavalli ◽  
Virginio Terulla ◽  
Francesca Airò ◽  
Catherine Klersy ◽  
...  

Development ◽  
1966 ◽  
Vol 16 (2) ◽  
pp. 289-300
Author(s):  
A. Jurand

Since the first observations of hypoplastic and aplastic thalidomide deformities in infants (McBride, 1961; Lenz, 1962), the literature on this subject has grown to many hundreds of communications. Experimental investigations in almost all cases have been undertaken to show whether thalidomide and its metabolites have any teratogenic effects in experimental animals. Numerous review papers are available on this subject, e.g. Giroud, Tuchmann-Duplessis & Mercier-Parot (1962), Somers (1963), and Salzgeber & Wolff (1964). Chick embryos did not seem for some time to be suitable for experimental production of typical thalidomide deformities. However, Kemper (1962a, b), Yang, Yang & Liang (1962). Boylen, Home & Johnson (1963) and Leone (1963) have shown that thalidomide can produce a whole range of ectromelian deformities provided that it is introduced into the egg at a particular period of embryonic development.


Nephrology ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 1065-1067
Author(s):  
Ugo Vertolli ◽  
Tamara Berno ◽  
Marcello Riva ◽  
Fausto Adami ◽  
Annalisa Angelini ◽  
...  

1993 ◽  
Vol 28 (2) ◽  
pp. 271-272 ◽  
Author(s):  
Giovanni Ghigliotti ◽  
Tiziana Repetto ◽  
Alessandro Farris ◽  
Maria Teresa Roy ◽  
Roberto De Marchi

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