Comparative Effects of Retinoic Acid, Glycolic Acid and a Lipophilic Derivative of Salicylic Acid on Photodamaged Epidermis

Dermatology ◽  
1999 ◽  
Vol 199 (1) ◽  
pp. 50-53 ◽  
Author(s):  
G.E. Piérard ◽  
A.M. Kligman ◽  
T. Stoudemayer ◽  
J.L. Lévêque
Keyword(s):  
Salicylic Acid ◽  
Retinoic Acid ◽  
Glycolic Acid ◽  
Lipophilic Derivative

scholarly journals Comparison of the Cerumenolytic Activities of New and Currently Used Agents

2021 ◽  
pp. 014556132098606
Author(s):  
Nguyen Quynh Anh ◽  
Pawin Numthavaj ◽  
Thongchai Bhongmakapat
Keyword(s):  
Salicylic Acid ◽  
Sodium Bicarbonate ◽  
Potassium Hydroxide ◽  
Glycolic Acid ◽  
Statistical Significance ◽  
In Vitro Study ◽  
Distilled Water ◽  
Moderate Amount ◽  
All Solutions

Objectives: This study compared the cerumen dissolution activities of 7.5% sodium bicarbonate, 5% potassium hydroxide, 10% lactic acid, 3% salicylic acid, 10% glycolic acid, and distilled water. Methods: An in vitro study was conducted with 36 cerumen samples. The cerumenolytic activities of the 6 agents were assessed by recording the degree of cerumen disintegration using digital photography at 15 minutes, 30 minutes, 1 hour, 2 hours, and 12 hours. The undissolved cerumen that remained after 12 hours was removed from the solutions and weighed after drying. Results: Potassium hydroxide showed the fastest cerumenolytic activity, dissolving a moderate amount of cerumen at 30 minutes, while glycolic acid and salicylic acid caused no visible changes in the cerumen samples. Samples treated with potassium hydroxide and sodium bicarbonate exhibited higher degrees of disintegration compared to samples treated with distilled water (odds ratio and 95% CI: 273.237 [0.203-367 470.4] and 1.129 [0.002-850.341], respectively). The greatest reduction in cerumen weight was associated with the use of sodium bicarbonate; however, this result did not reach statistical significance. Conclusions: Among the solutions tested, 5% potassium hydroxide showed the fastest dissolution activity, yielding moderate disintegration within only 30 minutes. In terms of residual cerumen weight within 12 hours, all solutions exhibited equivalent effectiveness in the disintegration of cerumen.

scholarly journals Study of glycolic acid and salicylic acid peels as a sole therapy in treatment of acne vulgaris

2016 ◽  
Vol 4 (12) ◽  
pp. 2205-2210 ◽  
Author(s):  
Dr. Parikshit Sharma ◽  
◽  
Dr. Akhil Shah ◽  
Dr. Alamjit singh Dhillon ◽  
◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris

scholarly journals Efficacious and safe management of thick scales, redness and flaky scalp condition using a specific shampoo containing urea, glycolic acid, salicylic acid, icthyol pale and laureth 9

2018 ◽  
Vol 5 (1) ◽  
pp. 1475095
Author(s):  
Bianca Maria Piraccini ◽  
Nicolò Brandi ◽  
Aurora Alessandrini ◽  
Francesca Bruni ◽  
Michela Starace
Keyword(s):  
Salicylic Acid ◽  
Glycolic Acid ◽  
Safe Management

Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris

2017 ◽  
Vol 17 (5) ◽  
pp. 797-801
Author(s):  
Jeong In Jae ◽  
Hyun Dong Ju ◽  
Kim Dong Hyun ◽  
Moon Soo Yoon ◽  
Hee Jung Lee
Keyword(s):  
Salicylic Acid ◽  
Acid Solution ◽  
Comparative Study ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Acid Ph

Intramolecular deactivation processes in complexes of salicylic acid or glycolic acid with Eu(III)

2010 ◽  
Vol 75 (4) ◽  
pp. 1333-1340 ◽  
Author(s):  
S. Kuke ◽  
B. Marmodée ◽  
S. Eidner ◽  
U. Schilde ◽  
M.U. Kumke
Keyword(s):  
Salicylic Acid ◽  
Glycolic Acid

scholarly journals Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 193 ◽  
Author(s):  
Ana Luiza C. de S. L. Oliveira ◽  
Raimundo Fernandes de Araújo Júnior ◽  
Thaís Gomes de Carvalho ◽  
Alan B. Chan ◽  
Timo Schomann ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Retinoic Acid ◽  
Antitumor Activity ◽  
Glycolic Acid ◽  
Plga Nanoparticles ◽  
Ki 67 ◽  
Apoptotic Proteins

Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-co-Glycolic Acid) (PLGA) nanoparticles for effective encapsulation and delivery of retinoic acid and oxaliplatin to analyze their antitumor activity in colorectal cancer. The cell viability and proliferation of tumoral cells lines (CT-26 and SW-480) decreased when compared to control in vitro after treatment with the nanoparticles. In addition, apoptosis of CT-26 cells increased. Importantly, cytoprotection of nontumor cells was detected. Expression of pro-apoptotic proteins was upregulated, while anti-apoptotic proteins were downregulated either in vitro or in vivo. In addition, drug resistance and metastasis factors were downregulated in vivo. Human colorectal tumors that highly expressed BCL-2 and Ki-67 had a greater tendency towards death within 60 months. Our results show that loading oxaliplatin combined with retinoic acid and cholesterol in a nanoparticle formulation enables determination of optimal antitumor activity and subsequent treatment efficacy.

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