Effect of Docosahexaenoic Acid Content of Maternal Diet on Auditory Brainstem Conduction Times in Rat Pups

2000 ◽  
Vol 22 (5-6) ◽  
pp. 494-499 ◽  
Author(s):  
Janet E. Stockard ◽  
Monisha D. Saste ◽  
Valerie J. Benford ◽  
Lewis Barness ◽  
Nancy Auestad ◽  
...  
Neonatology ◽  
2003 ◽  
Vol 84 (1) ◽  
pp. 45-52 ◽  
Author(s):  
A.O. Ajuyah ◽  
Y. Wang ◽  
H. Sunwoo ◽  
G. Cherian ◽  
J.S. Sim

1994 ◽  
Vol 41 (1) ◽  
pp. 23-27 ◽  
Author(s):  
E. Molina Grima ◽  
J. A. S�nchez P�rez ◽  
F. Garc�a Camacho ◽  
J. M. Fern�ndez Sevilla ◽  
F. G. Aci�n Fern�ndez

1998 ◽  
Vol 128 (4) ◽  
pp. 740-743 ◽  
Author(s):  
Monisha D. Saste ◽  
Jane D. Carver ◽  
Janet E. Stockard ◽  
Valerie J. Benford ◽  
Li T. Chen ◽  
...  

1997 ◽  
Vol 41 ◽  
pp. 241-241
Author(s):  
Janet E. Stockard ◽  
Jane D. Carver ◽  
Valerie J. Benford ◽  
Robert M. Nelson ◽  
Lewis A. Barness

Metabolites ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 40 ◽  
Author(s):  
Bo Yang ◽  
Runting Li ◽  
Taeseon Woo ◽  
Jimmy Browning ◽  
Hailong Song ◽  
...  

The abundance of docosahexaenoic acid (DHA) in the mammalian brain has generated substantial interest in the search for its roles in regulating brain functions. Our recent study with a gene/stress mouse model provided evidence to support the ability for the maternal supplement of DHA to alleviate autism-associated behavior in the offspring. DHA and arachidonic acid (ARA) are substrates of enzymatic and non-enzymatic reactions, and lipid peroxidation results in the production of 4-hydroxyhexenal (4-HHE) and 4-hydroxynonenal (4-HNE), respectively. In this study, we examine whether a maternal DHA-supplemented diet alters fatty acids (FAs), as well as lipid peroxidation products in the pup brain, heart and plasma by a targeted metabolite approach. Pups in the maternal DHA-supplemented diet group showed an increase in DHA and a concomitant decrease in ARA in all brain regions examined. However, significant increases in 4-HHE, and not 4-HNE, were found mainly in the cerebral cortex and hippocampus. Analysis of heart and plasma showed large increases in DHA and 4-HHE, but a significant decrease in 4-HNE levels only in plasma. Taken together, the DHA-supplemented maternal diet alters the (n-3)/(n-6) FA ratio, and increases 4-HHE levels in pup brain, heart and plasma. These effects may contribute to the beneficial effects of DHA on neurodevelopment, as well as functional changes in other body organs.


1999 ◽  
Vol 76 (5) ◽  
pp. 563-569 ◽  
Author(s):  
Yugo Iwasaki ◽  
Jeong Jun Han ◽  
Miho Narita ◽  
Roxana Rosu ◽  
Tsuneo Yamane

1994 ◽  
Vol 41 (1) ◽  
pp. 23-27 ◽  
Author(s):  
E. Molina Grima ◽  
J. A. S�nchez P�rez ◽  
F. Garc�a Camacho ◽  
J. M. Fern�ndez Sevilla ◽  
F. G. Aci�n Fern�ndez

Sign in / Sign up

Export Citation Format

Share Document