Frontotemporal Dementia Can Be Distinguished from Alzheimer’s Disease and Subcortical White Matter Dementia by an Anterior-to-Posterior rCBF-SPET Ratio

2000 ◽  
Vol 11 (5) ◽  
pp. 275-285 ◽  
Author(s):  
Magnus Sjögren ◽  
Lars Gustafson ◽  
Carsten Wikkelsö ◽  
Anders Wallin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Subcortical White Matter ◽  
White Matter Dementia

scholarly journals PET imaging of 18F-florbetapir in cognitively impaired individuals: Lack of activity within the cerebellar cortex

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Michael A. Meyer ◽  
Allison Caccia ◽  
Danielle Martinez ◽  
Mark A. Mingos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Cerebellar Cortex ◽  
Pet Imaging ◽  
Parent Compound ◽  
Hepatic Metabolism ◽  
Subcortical White Matter ◽  
Clinical Value ◽  
Type Pattern

Ten individuals suspected of having possible Alzheimer disease underwent PET imaging using 18F-Flubetapir. Only one of ten individuals had a pattern typical for normal elderly control subjects with 9 of the 10 showing a Alzheimer type pattern for the cerebral cortex yet all 10 subjects had uniformly low to absent tracer localization to the cerebellar cortex; significantly high tracer activity was noted within the subcortical white matter of the cerebellum in a symmetric manner in all cases. In consideration of studies that have shown amyloid deposits within the cerebellar cortex in 90% of pathologically proven cases of Alzheimer’s disease, these findings raise questions about the actual clinical value of florbetapir PET imaging in evaluating cerebellar involvement and raises questions whether PET imaging of this tracer accurately portrays patterns of amyloid deposition, as there is rapid hepatic metabolism of the parent compound after intravenous injection. Possible links to Alzheimer’s disease related alterations in blood-brain barrier permeability to the parent compound and subsequent radiolabelled metabolites are discussed as potential mechanisms that could explain the associated localization of the tracer to the brainstem and subcortical white matter within the cerebrum and cerebellum of Alzheimer’s disease patients.

scholarly journals White Matter Changes Associated with Resting Sympathetic Tone in Frontotemporal Dementia vs. Alzheimer’s Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142445 ◽  
Author(s):  
Mario F. Mendez ◽  
Aditi Joshi ◽  
Madelaine Daianu ◽  
Elvira Jimenez ◽  
Paul Thompson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Sympathetic Tone ◽  
White Matter Changes

scholarly journals White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

Brain ◽  
2009 ◽  
Vol 132 (9) ◽  
pp. 2579-2592 ◽  
Author(s):  
Y. Zhang ◽  
N. Schuff ◽  
A.-T. Du ◽  
H. J. Rosen ◽  
J. H. Kramer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Diffusion Mri ◽  
White Matter Damage

scholarly journals An advanced white matter tract analysis in frontotemporal dementia and early-onset Alzheimer’s disease

2015 ◽  
Vol 10 (4) ◽  
pp. 1038-1053 ◽  
Author(s):  
Madelaine Daianu ◽  
Mario F. Mendez ◽  
Vatche G. Baboyan ◽  
Yan Jin ◽  
Rebecca J. Melrose ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
White Matter Tract ◽  
Early Onset Alzheimer’S Disease

P1-083: Interrelation between gray and white matter alterations in Alzheimer's disease and frontotemporal dementia

2009 ◽  
Vol 5 (4S_Part_7) ◽  
pp. P197-P197
Author(s):  
Yu Zhang ◽  
Norbert Schuff ◽  
Christopher Ching ◽  
Duygu Tosun ◽  
Marzieh Nezamzadeh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia

Alzheimer's disease (AD) : AT8 recognizes degenerating ectopic neurons and astrocytes in the subcortical white matter.

2005 ◽  
Vol 161 (3) ◽  
pp. 338-339
Author(s):  
O. Bugiani ◽  
G. Giaccone ◽  
R. Capobianco ◽  
F. Tagliavini ◽  
B. Ghetti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Subcortical White Matter ◽  
Ectopic Neurons
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