h-sgk Serine-Threonine Protein Kinase as Transcriptional Target of p38/MAP Kinase pathway in HepG2 Human Hepatoma Cells

2000 ◽  
Vol 10 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Siegfried Waldegger ◽  
Sabine Gabrysch ◽  
Petra Barth ◽  
Sophie Fillon ◽  
Florian Lang
Keyword(s):  
Protein Kinase ◽  
Map Kinase ◽  
Hepatoma Cells ◽  
P38 Map Kinase ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Map Kinase Pathway ◽  
Kinase Pathway ◽  
Transcriptional Target

scholarly journals The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1006010 ◽  
Author(s):  
Serena A. D’Souza ◽  
Luckshi Rajendran ◽  
Rachel Bagg ◽  
Louis Barbier ◽  
Derek M. van Pel ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Motor Neurons ◽  
Leading Edge ◽  
P38 Map Kinase ◽  
Endosomal Trafficking ◽  
Guidance Cue ◽  
Map Kinase Pathway ◽  
Kinase Pathway

The proper display of transmembrane receptors on the leading edge of migrating cells and cell extensions is essential for their response to guidance cues. We previously discovered that MADD-4, which is an ADAMTSL secreted by motor neurons in Caenorhabditis elegans, interacts with an UNC-40/EVA-1 co-receptor complex on muscles to attract plasma membrane extensions called muscle arms. In nematodes, the muscle arm termini harbor the post-synaptic elements of the neuromuscular junction. Through a forward genetic screen for mutants with disrupted muscle arm extension, we discovered that a LAMMER kinase, which we call MADD-3, is required for the proper display of the EVA-1 receptor on the muscle’s plasma membrane. Without MADD-3, EVA-1 levels decrease concomitantly with a reduction of the late-endosomal marker RAB-7. Through a genetic suppressor screen, we found that the levels of EVA-1 and RAB-7 can be restored in madd-3 mutants by eliminating the function of a p38 MAP kinase pathway. We also found that EVA-1 and RAB-7 will accumulate in madd-3 mutants upon disrupting CUP-5, which is a mucolipin ortholog required for proper lysosome function. Together, our data suggests that the MADD-3 LAMMER kinase antagonizes the p38-mediated endosomal trafficking of EVA-1 to the lysosome. In this way, MADD-3 ensures that sufficient levels of EVA-1 are present to guide muscle arm extension towards the source of the MADD-4 guidance cue.

scholarly journals The PI 3-kinase-Rac-p38 MAP kinase pathway is involved in the formation of signet-ring cell carcinoma

Oncogene ◽  
2003 ◽  
Vol 22 (36) ◽  
pp. 5537-5544 ◽  
Author(s):  
Qingyun Xu ◽  
Yutaka Karouji ◽  
Michimoto Kobayashi ◽  
Sayoko Ihara ◽  
Hiroaki Konishi ◽  
...  
Keyword(s):  
Map Kinase ◽  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
P38 Map Kinase ◽  
Signet Ring ◽  
Ring Cell ◽  
Map Kinase Pathway ◽  
Kinase Pathway

Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib

2009 ◽  
pp. 1-13 ◽  
Author(s):  
Disha Dumka ◽  
Poonam Puri ◽  
Nathalie Carayol ◽  
Crystal Lumby ◽  
Harikrishnan Balachandran ◽  
...  
Keyword(s):  
Map Kinase ◽  
P38 Map Kinase ◽  
Map Kinase Pathway ◽  
Kinase Pathway

scholarly journals Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178769 ◽  
Author(s):  
Tsuyoshi Uchiyama ◽  
Fumikazu Okajima ◽  
Chihiro Mogi ◽  
Ayaka Tobo ◽  
Shoichi Tomono ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Map Kinase ◽  
P38 Map Kinase ◽  
Map Kinase Pathway ◽  
Leptin Expression ◽  
Kinase Pathway
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