Mouse centromere protein F (Cenpf) gene maps to the distal region of Chromosome 1 by interspecific backcross analysis

1998 ◽  
Vol 82 (3-4) ◽  
pp. 180-181
Author(s):  
K.J. Fowler ◽  
R. Saffery ◽  
D.V. Irvine ◽  
H.E. Trowell ◽  
K.H.A. Choo
Keyword(s):  
Interspecific Backcross ◽  
Distal Region ◽  
Chromosome 1 ◽  
Centromere Protein ◽  
Protein F ◽  
Gene Maps ◽  
Backcross Analysis ◽  
I Gene ◽  
Interspecific Backcross Analysis

Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis

Genomics ◽  
1991 ◽  
Vol 11 (2) ◽  
pp. 479-480 ◽  
Author(s):  
Nancy A. Jenkins ◽  
M.-Genevieve Mattei ◽  
Debra J. Gilbert ◽  
Christian G. Linard ◽  
Majambu Mbikay ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mouse Chromosome ◽  
Interspecific Backcross ◽  
Chromosome 2 ◽  
Mouse Chromosome 2 ◽  
Secretogranin I ◽  
Backcross Analysis ◽  
Interspecific Backcross Analysis

Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma

2013 ◽  
Vol 436 (4) ◽  
pp. 711-718 ◽  
Author(s):  
Yongdong Dai ◽  
Lulu Liu ◽  
Tingting Zeng ◽  
Ying-Hui Zhu ◽  
Jiangchao Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Centromere Protein ◽  
Protein F ◽  
Oncogenic Function

Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

Pathology ◽  
2015 ◽  
Vol 47 ◽  
pp. S94
Author(s):  
Fiona Moghaddas ◽  
Fredrick Joshua ◽  
Bobbie Taylor ◽  
Marv Fritzler ◽  
Ban Hock Toh
Keyword(s):  
Gene Mutation ◽  
Brca1 Gene ◽  
Brca1 Gene Mutation ◽  
Centromere Protein ◽  
Protein F

scholarly journals Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex–mediated acute lupus glomerulonephritis

2013 ◽  
Vol 210 (11) ◽  
pp. 2387-2401 ◽  
Author(s):  
Yan Ge ◽  
Chao Jiang ◽  
Sun-Sang J. Sung ◽  
Harini Bagavant ◽  
Chao Dai ◽  
...  
Keyword(s):  
Immune Complex ◽  
Organ Damage ◽  
Distal Region ◽  
Chromosome 1 ◽  
Chronic Glomerulonephritis ◽  
Female Mice ◽  
Inflammatory Parameters ◽  
Stage Renal Disease ◽  
End Stage ◽  
Lupus Glomerulonephritis

Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) and acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J region where Cgnz1 is located to NZM2328. R27 female mice developed aGN mediated by immune complex (IC) deposition and complement activation without progression to cGN with severe proteinuria. End stage renal disease (ESRD) was not seen in R27 mice as old as 15 mo. Thus, aGN and cGN are under separate genetic control, and IC-mediated proliferative GN need not progress to cGN and ESRD. NZM2328 and R27 female mice have comparable immune and inflammatory parameters. In contrast to NZM2328, R27 mice were resistant to sheep anti–mouse GBM serum-induced nephritis, supporting the hypothesis that aGN is mediated by autoimmunity and resistance to the development of cGN is mediated by end organ resistance to damage. Thus, autoimmunity should be considered distinct from end organ damage. The Cgnz1 region has been mapped to a 1.34 MB region with 45 genes. Nine candidate genes were identified. Clinical relevance of these observations is supported by case studies. Clinical implications and the significance to human lupus and other diseases are presented.

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