Assignment1 of the cyclin-dependent kinase inhibitor genes Cdkn2a and Cdkn2b to rat chromosome bands 5q32→q34 and 5q31→q33, respectively by fluorescence in situ hybridization, using small PCR-generated probes

1998 ◽  
Vol 81 (3-4) ◽  
pp. 290-291 ◽  
Author(s):  
J.-F. Laes ◽  
P. van Vooren ◽  
J. Szpirer ◽  
C. Szpirer
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Inhibitor Genes ◽  
Chromosome Bands

scholarly journals Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas

2018 ◽  
Vol 142 (12) ◽  
pp. 1549-1553 ◽  
Author(s):  
Kyra B. Berg ◽  
Sanja Dacic ◽  
Caitlyn Miller ◽  
Simon Cheung ◽  
Andrew Churg
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Internal Control ◽  
Kinase Inhibitor ◽  
Nuclear Staining ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Methylthioadenosine Phosphorylase ◽  
Almost All

Context.— The separation of reactive from malignant mesothelial proliferations is often a difficult morphologic problem. There is contradictory information in the literature on whether methylthioadenosine phosphorylase (MTAP) immunohistochemistry can be used for this purpose. Objective.— To determine the utility of MTAP immunohistochemistry in distinguishing reactive from malignant mesothelial proliferations. Design.— We stained a tissue microarray containing 20 epithelioid malignant mesotheliomas and 17 reactive mesothelial proliferations. For the mesotheliomas, comparisons were made between MTAP staining and BRCA-associated nuclear protein 1 (BAP1) immunohistochemistry, cyclin-dependent kinase inhibitor 2A (CDKN2A) fluorescence in situ hybridization, and neurofibromin 2 (NF2) fluorescence in situ hybridization, which are established techniques for making this separation. Results.— Loss of MTAP was seen in 0 of 17 reactive mesothelial proliferations and 13/20 (65%) malignant mesotheliomas. Almost all cases with loss showed loss in 100% of mesothelial cells. Background inflammatory and stromal cells served as a positive internal control. CDKN2A fluorescence in situ hybridization on the mesotheliomas showed concordance with MTAP staining in 14 of 17 evaluable cases. BAP1 immunohistochemistry showed loss of nuclear staining in 11 of 20 mesotheliomas (55%). No cases showed loss of NF2. A total of 18 of 20 mesotheliomas (90%) showed loss of either MTAP or BAP1. Conclusions.— In the context of a mesothelial proliferation, loss of MTAP staining is 100% specific for malignant mesothelioma. In this study the combination of MTAP and BAP1 immunohistochemical staining allowed separation of reactive from epithelial malignant mesothelial proliferations in 90% of cases.

Assignment of the TCRA/TCRD locus to sheep chromosome bands 7q1.4→q2.2 by fluorescence in situ hybridization

1997 ◽  
Vol 79 (3-4) ◽  
pp. 193-195 ◽  
Author(s):  
S. Massari ◽  
R. Antonacci ◽  
F. De Caro ◽  
M.R. Lipsi ◽  
S. Ciccarese
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Sheep Chromosome ◽  
Chromosome Bands

Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, andCDKN2C) in childhood rhabdomyosarcoma

1996 ◽  
Vol 15 (4) ◽  
pp. 217-222 ◽  
Author(s):  
Achille Iolascon ◽  
Maria Felicia Faienza ◽  
Brigida Coppola ◽  
Angelo Rosolen ◽  
Giuseppe Basso ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Childhood Rhabdomyosarcoma ◽  
Inhibitor Genes

THE ELEVATED EXPRESSION LEVEL IN CYCLIN-DEPENDENT KINASE INHIBITOR GENES IN TUMOR-BEARING MICE LIVER

2000 ◽  
Vol 28 (5) ◽  
pp. A239-A239
Author(s):  
E. Yoshinaga ◽  
H. Matsuo ◽  
R. Uesugi-Hayakawa ◽  
A. Tajima ◽  
C. Nisiwaki ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Expression Level ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Tumor Bearing ◽  
Elevated Expression ◽  
Mice Liver ◽  
Inhibitor Genes

Assignment1 of the STOP gene (MAP6) to human chromosome bands 6p12→p11 by fluorescence in situ hybridization

1999 ◽  
Vol 86 (1) ◽  
pp. 25-25
Author(s):  
C. Jolly ◽  
E. Denarier ◽  
F. Mongelard ◽  
M. Robert-Nicoud ◽  
C. Vourc’h ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Fluorescence In Situ Hybridization ◽  
Chromosome Bands
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