Comparative FISH-mapping of the prion protein gene (PRNP) on cattle, river buffalo, sheep and goat chromosomes

1998 ◽  
Vol 81 (3-4) ◽  
pp. 202-204 ◽  
Author(s):  
L. Iannuzzi ◽  
R. Palomba ◽  
G.P. Di Meo ◽  
A. Perucatti ◽  
L. Ferrara
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
River Buffalo ◽  
Fish Mapping

CHARACTERISTICS OF ALLELE POOL OF THE ROMANOV SHEEP BREED FOR THE PRION PROTEIN GENE ASSOCIATED WITH GENETIC SUSTAINABILITY TO SCRAPIE

2017 ◽  
Vol 52 (6) ◽  
pp. 1157-1165
Author(s):  
E.A. Gladyr ◽  
◽  
T.E. Deniskova ◽  
V.A. Bagirov ◽  
O.V. Kostyunina ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Sheep Breed ◽  
Prion Protein Gene ◽  
Allele Pool

scholarly journals The First Report of the Prion Protein Gene (PRNP) Sequence in Pekin Ducks (Anas platyrhynchos domestica): The Potential Prion Disease Susceptibility in Ducks

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 193
Author(s):  
Min-Ju Jeong ◽  
Yong-Chan Kim ◽  
Byung-Hoon Jeong
Keyword(s):  
Prion Protein ◽  
Dna Sequence ◽  
Prion Disease ◽  
Protein Gene ◽  
Prnp Gene ◽  
Pekin Duck ◽  
Prion Protein Gene ◽  
First Report ◽  
Aggregation Propensity ◽  
Pekin Ducks

Pathogenic prion protein (PrPSc), converted from normal prion protein (PrPC), causes prion disease. Although prion disease has been reported in several mammalian species, chickens are known to show strong resistance to prion diseases. In addition to chickens, the domestic duck occupies a large proportion in the poultry industry and may be regarded as a potential resistant host against prion disease. However, the DNA sequence of the prion protein gene (PRNP) has not been reported in domestic ducks. Here, we performed amplicon sequencing targeting the duck PRNP gene with the genomic DNA of Pekin ducks. In addition, we aligned the PrP sequence of the Pekin duck with that of various species using ClustalW2 and carried out phylogenetic analysis using Molecular Evolutionary Genetics Analysis X (MEGA X). We also constructed the structural modeling of the tertiary and secondary structures in avian PrP using SWISS-MODEL. Last, we investigated the aggregation propensity on Pekin duck PrP using AMYCO. We first reported the DNA sequence of the PRNP gene in Pekin ducks and found that the PrP sequence of Pekin ducks is more similar to that of geese than to that of chickens and mallards (wild ducks). Interestingly, Pekin duck PrP showed a high proportion of β-sheets compared to that of chicken PrP, and a high aggregation propensity compared to that of avian PrPs. However, Pekin duck PrP with substitutions of chicken-specific amino acids showed reduced aggregation propensities. To the best of our knowledge, this is the first report on the genetic characteristics of the PRNP sequence in Pekin ducks.

A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene

2006 ◽  
Vol 151 (9) ◽  
pp. 1875-1880 ◽  
Author(s):  
P. L. Acutis ◽  
F. Martucci ◽  
M. Mazza ◽  
S. Peletto ◽  
B. Iulini ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene

Prion protein gene analysis in new variant cases of Creutzfeldt-Jakob disease

The Lancet ◽  
1996 ◽  
Vol 348 (9019) ◽  
pp. 56 ◽  
Author(s):  
John Collinge ◽  
Jonathan Beck ◽  
Tracy Campbell ◽  
Kathy Estibeiro ◽  
Robert G Will
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Gene Analysis ◽  
Prion Protein Gene ◽  
New Variant ◽  
Jakob Disease

Magnetic Resonance Imaging in E200K and V210I Mutations of the Prion Protein Gene

2013 ◽  
Vol 27 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Maren Breithaupt ◽  
Carlos Romero ◽  
Kai Kallenberg ◽  
Christian Begue ◽  
Pascual Sanchez-Juan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Resonance Imaging

Effect of a Polymorphism on the Pathogenic 178Asn Mutation in the Prion Protein Gene

1993 ◽  
Vol 52 (3) ◽  
pp. 293
Author(s):  
R B Petersen ◽  
L Goldfarb ◽  
M Tabaton ◽  
P Brown ◽  
A LeBlanc ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene

Novel prion protein gene mutation at codon 196 (E196A) in a septuagenarian with Creutzfeldt–Jakob disease

2014 ◽  
Vol 21 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Hongliang Zhang ◽  
Meibo Wang ◽  
Limin Wu ◽  
Haining Zhang ◽  
Tao Jin ◽  
...  
Keyword(s):  
Prion Protein ◽  
Gene Mutation ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Jakob Disease

scholarly journals Prion Protein Gene-Deficient Cell Lines: Powerful Tools for Prion Biology

2007 ◽  
Vol 51 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Akikazu Sakudo ◽  
Takashi Onodera ◽  
Kazuyoshi Ikuta
Keyword(s):  
Prion Protein ◽  
Cell Lines ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Deficient Cell

A new allelic variant in the bovine prion protein gene (PRNP) coding region

1999 ◽  
Vol 30 (5) ◽  
pp. 386-387 ◽  
Author(s):  
J Schläpfer ◽  
N Saitbekova ◽  
C Gaillard ◽  
G Dolf
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Allelic Variant ◽  
Prion Protein Gene ◽  
Coding Region
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