Vascular Endothelial Growth Factor in Pulmonary Lavage Fluid from Premature Infants: Effects of Age and Postnatal Dexamethasone

Neonatology ◽  
1999 ◽  
Vol 76 (5) ◽  
pp. 266-273 ◽  
Author(s):  
Carl T. D’Angio ◽  
William M. Maniscalco ◽  
Rita M. Ryan ◽  
Nelly E. Avissar ◽  
Kumar Basavegowda ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Premature Infants ◽  
Lavage Fluid ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid in Sulfur Mustard Exposed Lung Patients

2011 ◽  
Vol 26 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Ali Karami ◽  
Mostafa Ghanei ◽  
Farshid Alaeddini ◽  
Mohammad Javad Soltanpour ◽  
Fatemeh Pourali ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Sulfur Mustard ◽  
Lavage Fluid ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor‐121 Administration Mitigates Halogen Inhalation‐Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
Dylan R. Addis ◽  
James A. Lambert ◽  
Changchun Ren ◽  
Stephen Doran ◽  
Saurabh Aggarwal ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Vascular Endothelial ◽  
Pregnant Mice ◽  
Endothelial Growth Factor

Background Circulating levels of sFLT‐1 (soluble fms‐like tyrosine kinase 1), the extracellular domain of vascular endothelial growth factor (VEGF) receptor 1, and its ratio to levels of placental growth factor are markers of the occurrence and severity of preeclampsia. Methods and Results C57BL/6 pregnant mice on embryonic day 14.5 (E14.5), male, and non‐pregnant female mice were exposed to air or to Br 2 at 600 ppm for 30 minutes and were treated with vehicle or with VEGF‐121 (100 μg/kg, subcutaneously) daily, starting 48 hours post‐exposure. Plasma, bronchoalveolar lavage fluid, lungs, fetuses, and placentas were collected 120 hours post‐exposure. In Br 2 ‐exposed pregnant mice, there was a time‐dependent and significant increase in plasma levels of sFLT‐1 which correlated with increases in mouse lung wet/dry weights and bronchoalveolar lavage fluid protein content. Supplementation of exogenous VEGF‐121 improved survival and weight gain, reduced lung wet/dry weights, decreased bronchoalveolar lavage fluid protein levels, enhanced placental development, and improved fetal growth in pregnant mice exposed to Br 2 . Exogenous VEGF‐121 administration had no effect in non‐pregnant mice. Conclusions These results implicate inhibition of VEGF signaling driven by sFLT‐1 overexpression as a mechanism of pregnancy‐specific injury leading to lung edema, maternal mortality, and fetal growth restriction after bromine gas exposure.

Sign in / Sign up

Export Citation Format

Share Document