Targeted Deletion of the Cytosolic Cu/Zn-Superoxide Dismutase Gene (Sod1) Increases Susceptibility to Noise-Induced Hearing Loss

1999 ◽  
Vol 4 (5) ◽  
pp. 237-246 ◽  
Author(s):  
Kevin K. Ohlemiller ◽  
Sandra L. McFadden ◽  
Da-Lian Ding ◽  
Dorothy G. Flood ◽  
Andrew G. Reaume ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Targeted Deletion ◽  
Superoxide Dismutase Gene ◽  
Susceptibility To Noise

scholarly journals SOD2 V16A SNP in the Mitochondrial Targeting Sequence is Associated with Noise Induced Hearing Loss in Chinese Workers

2010 ◽  
Vol 28 (3) ◽  
pp. 137-147 ◽  
Author(s):  
Yi-Min Liu ◽  
Xu-Dong Li ◽  
Xiao Guo ◽  
Bin Liu ◽  
Ai-Hua Lin ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Noise Induced Hearing Loss ◽  
Nucleotide Polymorphisms ◽  
Mitochondrial Targeting ◽  
Chinese Han ◽  
Chinese Workers ◽  
Superoxide Dismutase Gene ◽  
Susceptibility To Noise ◽  
Main Effects

Objective:To investigate whether single nucleotide polymorphisms (SNPs) in the Mn-superoxide dismutase gene (SOD2) underlie the susceptibility to noise-induced hearing loss (NIHL).Methods:Audiometric data from 2400 Chinese Han workers who exposed to occupational noise were analyzed. DNA samples were collected from the 10% most susceptible and the 10% most resistant individuals, and five SNPs (SOD2 rs2842980, rs5746136, rs2758331, rs4880 and rs5746092) were genotyped by Taqman SNP Genotyping Kits. The SNP main effects and interactions between noise exposure and SNP were analyzed using logistic regression. Haplotypes were analyzed by using Haploview software.Results:The CT genotype of rs4880 (SOD2 V16A SNP) was associated with a higher risk of NIHL (covariates-adjusted OR, 2.18; 95% CI, 1.34–3.54,P= 0.002). Haplotype analysis revealed that the frequency of AGCCG at the five SNP loci was significantly higher in the susceptible group (P= 0.020). With AGCTG as the reference, the OR (95% CI) was 2.63 (1.14, 6.06). The rs4880 polymorphisms imposed larger effects when the carriers were exposed to higher levels of noise, indicating the interaction between SNP and noise exposure.Conclusions:Our results suggest that SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers, and this effect was enhanced by higher levels of noise exposure.

scholarly journals Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

PLoS Genetics ◽  
2015 ◽  
Vol 11 (4) ◽  
pp. e1005094 ◽  
Author(s):  
Joel Lavinsky ◽  
Amanda L. Crow ◽  
Calvin Pan ◽  
Juemei Wang ◽  
Ksenia A. Aaron ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Noise Induced Hearing Loss ◽  
Genome Wide ◽  
Susceptibility To Noise

Individual Susceptibility to Noise-Induced Hearing loss

1993 ◽  
Vol 14 (3) ◽  
pp. 152-168 ◽  
Author(s):  
Donald Henderson ◽  
Malini Subramaniam ◽  
Flint A. Boettcher
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Individual Susceptibility ◽  
Susceptibility To Noise

Susceptibility to Noise-Induced Hearing Loss: Review and Future Directions

1984 ◽  
Vol 149 (3) ◽  
pp. 154-158 ◽  
Author(s):  
Ernest L. Hepler ◽  
Michael J. Moul ◽  
Kenneth J. Gerhardt
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
Future Directions ◽  
Susceptibility To Noise

Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice

2002 ◽  
Vol 164 (1-2) ◽  
pp. 231-239 ◽  
Author(s):  
Peter J Kozel ◽  
Rickie R Davis ◽  
Edward F Krieg ◽  
Gary E Shull ◽  
Lawrence C Erway
Keyword(s):  
Hearing Loss ◽  
Plasma Membrane ◽  
Calcium Atpase ◽  
Noise Induced Hearing Loss ◽  
Plasma Membrane Calcium Atpase ◽  
Susceptibility To Noise
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