Left Ventricular Hypertrophy in Hypertensive Patients with Autosomal Dominant Polycystic Kidney Disease: Influence of Blood Pressure and Humoral and Neurohormonal Factors

2000 ◽  
Vol 20 (3) ◽  
pp. 193-200 ◽  
Author(s):  
Alberto Martinez-Vea ◽  
F. Alfredo Valero ◽  
Alfredo Bardaji ◽  
Cristina Gutierrez ◽  
Montse Broch ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Polycystic Kidney Disease ◽  
Ventricular Hypertrophy ◽  
Autosomal Dominant ◽  
Left Ventricular ◽  
Polycystic Kidney ◽  
Hypertensive Patients ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Left ventricular hypertrophy in a contemporary cohort of autosomal dominant polycystic kidney disease patients

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Huanwen Chen ◽  
Terry Watnick ◽  
Susie N. Hong ◽  
Barry Daly ◽  
Yongfang Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Linear Regression ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Autosomal Dominant ◽  
Left Ventricular ◽  
Polycystic Kidney ◽  
Lv Mass ◽  
Autosomal Dominant Polycystic Kidney

Abstract Background Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) often develop hypertension in childhood or early adulthood. Although this could result in left ventricular hypertrophy (LVH), a major risk factor for cardiovascular morbidity and mortality, prior studies of LVH in ADPKD have yielded conflicting results. We estimated the prevalence of LVH using consensus echocardiography criteria and examined the independent association of ADPKD severity with LV mass in a contemporary cohort of ADPKD patients. Methods Adults with ADPKD and eGFR> 15 ml/min/1.73m2 were enrolled in a single-center study. Left Ventricular Mass (LVM) was quantified using 2D echocardiography, and LVH was defined using gender-specific cut-points of LVM and LVM indexed to body surface area (LVMI) from consensus guidelines. Total Kidney Volume (TKV) was quantified using Magnetic Resonance Imaging, and GFR was estimated from serum creatinine using the CKD-Epi equation. Multiple linear regression was used to estimate the association of TKV and eGFR with LVM and LVMI, adjusting for potential confounders. Results Among 126 participants (78% with hypertension), median age was 46 years, median eGFR 63 ml/min/1.73 m2, and median [IQR] systolic blood pressure was 125 [116–133] mmHg. Prevalence of LVH was 21.4% as defined by LVMI and was not significantly different (p = 0.8) between those with and without HTN, and was similar (21.4%) after excluding those (N = 21) with known cardiac disease. Greater TKV and lower eGFR were directly correlated with greater LVMI (p = .016 and p < .001, respectively). In multiple linear regression models accounting for potential confounders including blood pressure, greater TKV was positively associated with LVM ($$ \hat{\beta} $$ β ̂ =0.19, p = 0.04). Conclusions In a contemporary cohort of ADPKD patients with well-controlled blood pressure, the prevalence of LVH is high, and ADPKD severity as reflected by TKV is independently associated with greater LV mass. These results may suggest a relationship between ADPKD pathophysiology and increased LV mass.

scholarly journals The Polymorphism of the ACE Gene Affects Left Ventricular Hypertrophy and Causes Disturbances in Left Ventricular Systolic/Diastolic Function in Patients with Autosomal Dominant Polycystic Kidney Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Wanic-Kossowska ◽  
Bartlomiej Posnik ◽  
Mikolaj Kobelski ◽  
Elzbieta Pawliczak ◽  
Krzysztof Pawlaczyk ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Diastolic Function ◽  
Polycystic Kidney Disease ◽  
Ventricular Hypertrophy ◽  
Autosomal Dominant ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most frequently occurring autosomal diseases inherited in the dominant manner. Due to this, lesions in the cardiovascular system of ADPKD patients have caught the attention of clinical investigators worldwide. The aim of the study was to analyse cardiovascular complications in ADPKD patients with a focus on left ventricular hypertrophy (LVH) and selected components of its systolic/diastolic function based on echocardiography. The study was conducted on 55 patients with ADPKD (24 males, 31 females), subdivided into three groups according to the stage of chronic kidney disease (CKD). The patient group with ADPKD and ESRD (group C) manifested an increased incidence of the D allele as compared to group A and group B (χ2=4.217,P=0.04). In all ADPKD patients with the DD genotype, left ventricular mass (LVM), posterior wall thickness (PWT), and interventricular septal thickness (IVS) were significantly higher compared to patients possessing the II and ID genotypes (P<0.02,P<0.003, andP<0.009, resp.). The DD genotype exists more frequently in ADPKD patients with ESRD and is associated with a higher occurrence of LVH and disturbances in systolic-diastolic function when compared to ADPKD ESRD patients with the II and ID genotypes.

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