Correlations among Expression of Glomerular Intercellular Adhesion Molecule 1 (ICAM-1), Levels of Serum Soluble ICAM-1, and Renal Histopathology in Patients with IgA Nephropathy

1999 ◽  
Vol 19 (4) ◽  
pp. 495-499 ◽  
Author(s):  
Tat Thang Nguyen ◽  
Ichiyu Shou ◽  
Kazuhiko Funabiki ◽  
Isao Shirato ◽  
Kiichi Kubota ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Renal Histopathology

Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis

1991 ◽  
Vol 81 (s25) ◽  
pp. 477-481 ◽  
Author(s):  
K. Lhotta ◽  
H. P. Neumayer ◽  
M. Joannidis ◽  
D. Geissler ◽  
P. KöNig
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Adhesion Molecule ◽  
Membranoproliferative Glomerulonephritis ◽  
Rapidly Progressive Glomerulonephritis ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Segmental Glomerulosclerosis ◽  
Mesangioproliferative Glomerulonephritis

1. Expression of intercellular adhesion molecule-1 was investigated in five normal kidneys and 47 renal biopsies with the use of monoclonal antibody 7F7 and immunoperoxidase staining. 2. In the normal kidney, intercellular adhesion molecule-1 was expressed on endothelial cells of glomerular and peritubular capillaries, on Bowman's capsule, on some interstitial cells and weakly in the mesangium. 3. Increased glomerular staining was detected in early cases of rapidly progressing glomerulonephritis (5/8) and in some cases of non-IgA mesangioproliferative glomerulonephritis (5/9), IgA nephropathy (3/5), Henoch-Schoenlein purpura (2/2), lupus nephritis (5/6) and focal segmental glomerulosclerosis (1/3). A decrease in intercellular adhesion molecule-1 expression was noted in advanced rapidly progressive glomerulonephritis (3/8), two cases of membraneous nephropathy, one severe mesangioproliferative glomerulonephritis biopsy, the two membranoproliferative glomerulonephritis biopsies and in sclerotic loops in focal segmental glomerulosclerosis. 4. Expression de novo on tubular epithelial cells occurred in rapidly progressive glomerulonephritis, in membranoproliferative glomerulonephritis, and to a lesser extent in some cases of membranous nephropathy, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, a severe case of mesangioproliferative glomerulonephritis and in the mixed essential cryoglobulinaemia case. In 63% of positive tubuli, intraluminal cells which expressed CD18, the common β-chain of leucocyte-function-associated antigen-1, Mac-1 and p150,95, were present. 5. Intercellular adhesion molecule-1 was also found on the majority (59%) of infiltrating mononuclear cells in all forms of glomerulonephritis.

Expression of Intercellular Adhesion Molecule-1 and Infiltration of Lymphocytes in Glomeruli of Patients with IgA Nephropathy

Nephron ◽  
1994 ◽  
Vol 67 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Yasuhiko Tomino ◽  
Hiroyuki Ohmuro ◽  
Takao Kuramoto ◽  
Isao Shirato ◽  
Kazuhiko Eguchi ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

Control of islet intercellular adhesion molecule-1 expression by interferon-alpha and hypoxia

Diabetes ◽  
1996 ◽  
Vol 45 (10) ◽  
pp. 1336-1343 ◽  
Author(s):  
D. Chakrabarti ◽  
X. Huang ◽  
J. Beck ◽  
J. Henrich ◽  
N. McFarland ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1
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