Proteinuria and Renal Tubular Damage: Urinary N-Acetyl- β-D-Glucosaminidase and Isoenzymes in Dissimilar Renal Disease

1998 ◽  
Vol 18 (3) ◽  
pp. 179-185 ◽  
Author(s):  
Rana Rustom ◽  
Michael Costigan ◽  
Alan Shenkin ◽  
J. Michael Bone
Keyword(s):  
Renal Disease ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular

Fractional excretion of magnesium as an early indicator of renal tubular damage in normotensive diabetic nephropathy

2020 ◽  
Vol 45 (5) ◽  
pp. 543-551
Author(s):  
Fatih Ozcelik ◽  
Serif Kactas ◽  
Halime Hanim Pence ◽  
Saadet Kurcenli ◽  
Erdim Sertoglu ◽  
...  
Keyword(s):  
Fractional Excretion ◽  
Study Patient ◽  
Control Group ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular ◽  
Excretion Rates ◽  
Urine And Serum ◽  
Diagnostic And Prognostic Value

AbstractObjectivesThe aim of the present study is to evaluate the diagnostic powers of fractional magnesium, sodium and potassium as markers of renal tubular damage in normotensive type 2 diabetes mellitus (T2DM) patients with respect to microalbuminuria and estimated glomerular filtration rate (eGFR).Materials and methodsForty healthy volunteers and 91 normotensive T2DM patients were included in the study. Patient group was divided into two according to albuminuria level; 49 were normoalbuminuric and 42 were microalbuminuric. In addition to albumin in urine, urine and serum Na, K, Mg and creatinine values were measured to calculate fractional electrolyte excretion rates.ResultsIn normoalbuminuric and microalbuminuric groups, fractional excretion of magnesium (FEMg) values were found to be significantly higher than the control group (p < 0.05). There was a moderate correlation between FEMg and albümin to cratinin ratio (ACR) (Spearman r = 0.3215, p < 0.05). In the ROC analysis for eGFR and FEMg based on microalbuminuria, the areas under the curve were 0.625 and 0.732, respectively (diagnostic sensitivity 59.52% and 66.67%; specificity 70.79% and 77.53%, p < 0.05).ConclusionFor renal tubular damage predicted by microalbuminuria, FEMg could be accepted as a candidate biochemical marker with diagnostic and prognostic value.

Tactical approaxhes to diagnosis and treatment of hepatorenal syndrome in patients with blastomatous obstructive jaundice

2021 ◽  
Vol 42 (2) ◽  
pp. 28-31
Author(s):  
S. V. Kosulin ◽  
◽  
Ju. O. Vinnik ◽  
Ju. V. Ivanova ◽  
◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Hepatorenal Syndrome ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Coagulation System ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular ◽  
Neutrophil Gelatinase

The article discusses problems of early diagnosis and, accordingly, treatment of hepatorenal syndrome (HRS) in case of obstructive jaundice of blastomatous origin. The results of a comprehensive examination of 37 patients with blastomatous obstructive jaundice (OJ) with clinical and laboratory signs of HRS were analyzed. Patients were evaluated for clinical and biochemical parameters of blood and urine, blood electrolytes, indicators of the blood coagulation system according to unified methods. The main work is devoted to the determination of the biomarker of renal tubular damage, neutrophil-gelatinase-associated lipocaine (s-NGAL) as a marker and indicator of HRS severity, careful and detailed analysis, monitoring of levels (s-NGAL) and other bioactive substances as an indicator of treatment efficacy. Introduction of active ultrasound as a replacement for contrast computer tomography to reduce the load on precompromised kidneys. It has been proven that the level of renal tubular damage, neutrophil-gelatinase-associated lipocaine s-NGAL is an early marker of renal damage whose function is to reduce the severity of damage to the proximal tubules of the kidneys, normalize damaged tissue by participating in apoptosis, increase survival of damaged restoration of damaged epithelium, stimulation of differentiation and structural reorganization of renal epithelial cells. The fact that s-NGAL was not significantly reduced in the stage of recovery of diuresis, confirms the presence of patients with blastomatous MF severe and persistent toxic tubulointerstitial disorders. Based on this determination of the biomarker (s-NGAL) in the serum of patients with blastomatous mechanical jaundice and performing in them at primary ultrasound color Doppler mapping and pulsed wave Doppler imaging of the kidneys with the calculation of the resistance index may serve as early signs of damage.

Chronic Renal Tubular Damage Caused by Cyclosporin A

1989 ◽  
pp. 309-314
Author(s):  
P. H. Whiting ◽  
N. J. Saunders ◽  
K. J. Thomson ◽  
J. G. Simpson
Keyword(s):  
Cyclosporin A ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular

Silencing of SOCS‐1 and SOCS‐3 suppresses renal interstitial fibrosis by alleviating renal tubular damage in a rat model of hydronephrosis

2017 ◽  
Vol 119 (2) ◽  
pp. 2200-2211 ◽  
Author(s):  
Gui‐Hong Zheng ◽  
Yong‐Jian Wang ◽  
Xin Wen ◽  
Xin‐Rui Han ◽  
Min Shen ◽  
...  
Keyword(s):  
Rat Model ◽  
Interstitial Fibrosis ◽  
Tubular Damage ◽  
Renal Interstitial Fibrosis ◽  
Renal Tubular Damage ◽  
Renal Tubular

scholarly journals Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury

Biology Open ◽  
2021 ◽  
Author(s):  
Taro Miyagawa ◽  
Yasunori Iwata ◽  
Megumi Oshima ◽  
Hisayuki Ogura ◽  
Koichi Sato ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Advanced Glycation End Products ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Tubular Damage ◽  
Advanced Glycation ◽  
Renal Tubular Damage ◽  
Glycation End Products ◽  
End Products ◽  
Renal Tubular

The full-length receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor. High-mobility group box 1 (HMGB1) is a RAGE ligand of damage-associated molecular patterns that elicits inflammatory reactions. The shedded isoform of RAGE and endogenous secretory RAGE (esRAGE), a splice variant, are soluble isoforms (sRAGE) that act as organ-protective decoys. However, the pathophysiologic roles of RAGE/sRAGE in acute kidney injury (AKI) remain unclear. We found that AKI was more severe, with enhanced renal tubular damage, macrophage infiltration, and fibrosis, in mice lacking both RAGE and sRAGE than in wild-type control mice. Using murine tubular epithelial cells (TECs), we demonstrated that hypoxia upregulated messenger RNA (mRNA) expression of HMGB1 and tumor necrosis factor α (TNF-α), whereas RAGE and esRAGE expressions were paradoxically decreased. Moreover, the addition of recombinant sRAGE canceled hypoxia-induced inflammation and promoted cell viability in cultured TECs. sRAGE administration prevented renal tubular damage in models of ischemia/reperfusion-induced AKI and of anti-glomerular basement membrane (anti-GBM) glomerulonephritis. These results suggest that sRAGE is a novel therapeutic option for AKI.

Renal Tubular Damage After Renal Stone Treatment

1989 ◽  
Vol 141 (2) ◽  
pp. 465-465
Author(s):  
A. Trinchieri ◽  
A. Mandressi ◽  
G. Zanetti ◽  
M. Ruoppolo ◽  
P. Tombolini ◽  
...  
Keyword(s):  
Renal Stone ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Stone Treatment ◽  
Renal Tubular

scholarly journals Benchmark Dose Estimation for Cadmium-Induced Renal Tubular Damage among Environmental Cadmium-Exposed Women Aged 35–54 Years in Two Counties of China

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115794 ◽  
Author(s):  
Jia Hu ◽  
Mei Li ◽  
Tian-xu Han ◽  
Jian-wei Chen ◽  
Lin-xiang Ye ◽  
...  
Keyword(s):  
Benchmark Dose ◽  
Tubular Damage ◽  
Dose Estimation ◽  
Renal Tubular Damage ◽  
Renal Tubular

Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex

2014 ◽  
Vol 38 (1) ◽  
pp. 272-278 ◽  
Author(s):  
Yong-Dae Kim ◽  
Dong-Hyuk Yim ◽  
Sang-Yong Eom ◽  
Sun-In Moon ◽  
Choong-Hee Park ◽  
...  
Keyword(s):  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular
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