Expression of Insulin-Like Growth Factor-2 Can Predict the Prognosis of Human Colorectal Cancer Patients: Correlation with Tumor Progression, Proliferative Activity and Survival

Oncology ◽  
1998 ◽  
Vol 55 (3) ◽  
pp. 242-248 ◽  
Author(s):  
Kazuyuki Kawamoto ◽  
Hisashi Onodera ◽  
Shohei Kondo ◽  
Shugen Kan ◽  
Daisuke Ikeuchi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Proliferative Activity ◽  
Insulin Like Growth Factor ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Patients

scholarly journals Transforming Growth Factor Beta-1 in Human Colorectal Cancer Patients

2011 ◽  
Vol 8 (1) ◽  
Author(s):  
Özgür Kemik ◽  
Ahu Sarbay Kemik ◽  
Sevim Purisa ◽  
İsmail Hasırcı ◽  
Ahmet Cumhur Dülger ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Cancer Patients ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Human Colorectal Cancer ◽  
Growth Factor Beta ◽  
Colorectal Cancer Patients

scholarly journals Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan

2010 ◽  
Vol 127 (8) ◽  
pp. 1941-1947 ◽  
Author(s):  
Mario Scartozzi ◽  
Alessandra Mandolesi ◽  
Riccardo Giampieri ◽  
Chiara Pierantoni ◽  
Fotios Loupakis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Clinical Outcome ◽  
Cancer Patients ◽  
Insulin Like Growth Factor ◽  
Wild Type ◽  
Colorectal Cancer Patients

Preoperative Vascular Endothelial Growth Factor Levels as a Prognostic Marker for Stage II or III Colorectal Cancer Patients

2011 ◽  
Vol 4 ◽  
pp. CGM.S7113 ◽  
Author(s):  
Ozgur Kemik ◽  
Ahu Sarbay Kemik ◽  
Aziz Sümer ◽  
Sevim Purisa ◽  
A. Cumhur Dulger ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Patients ◽  
Elevated Serum ◽  
Stage Ii ◽  
Vascular Endothelial ◽  
Poor Survival ◽  
Colorectal Cancer Patients ◽  
Endothelial Growth Factor

Background The aim of the present study was to determine whether serum vascular endothelial growth factor (VEGF) can provide prognostic information independent of carcinoembryonic antigen levels in patients undergoing curative surgery. Methods Serum samples were collected from 158 patients with colorectal cancer and from 100 controls. Serum and tissue levels of VEGF were measured by enzyme-linked immunosorbent assay. Serum VEGF levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum VEGF levels and clinicopathologic findings and survival. Results VEGF expression was significantly higher in colorectal cancer tissue compared with nontumor tissue. Mean serum VEGF levels in patients were significantly higher than those in controls, and significantly higher in patients with large tumors, lymph node involvement, and distant metastases. Conclusion Elevated serum VEGF was significantly associated with poor survival, but was only an independent risk factor for poor survival in Stage II and/or III disease. Elevated serum VEGF is significantly associated with development of colorectal cancer, and lymph or distant invasive phenotypes and survival, especially in Stage II and III patients.

MACC1 Induces Tumor Progression in Transgenic Mice and Colorectal Cancer Patients via Increased Pluripotency Markers Nanog and Oct4

2016 ◽  
Vol 22 (11) ◽  
pp. 2812-2824 ◽  
Author(s):  
Clara Lemos ◽  
Markus S. Hardt ◽  
Manisha Juneja ◽  
Cynthia Voss ◽  
Susann Förster ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transgenic Mice ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Pluripotency Markers ◽  
Colorectal Cancer Patients
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