Connective Tissue Formation in Subcutaneous Cellulose Sponge Implants in the Rat

1998 ◽  
Vol 30 (6) ◽  
pp. 419-425 ◽  
Author(s):  
M. Märtson ◽  
J. Viljanto ◽  
P. Laippala ◽  
P. Saukko
Keyword(s):  
Connective Tissue ◽  
Tissue Formation ◽  
Cellulose Sponge

scholarly journals The action of demineralized bovine bone matrix on bone neoformation in rats submitted to experimental alcoholism

2013 ◽  
Vol 65 (3) ◽  
pp. 715-721 ◽  
Author(s):  
R.L. Buchaim ◽  
J.C. Andreo ◽  
A. C. Rodrigues ◽  
D.V. Buchaim ◽  
D.V. Dias ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Bone Repair ◽  
Blood Clot ◽  
Bone Matrix ◽  
Male Rats ◽  
Bovine Bone ◽  
Filling Material ◽  
Tissue Formation ◽  
Bone Trabeculae ◽  
Bone Tissue Formation

The objective of this study was to evaluate whether demineralized bovine bone (Gen-ox®) alters bone neoformation in rats submitted to alcoholism. Forty male rats were separated into two groups of 20 rats and distributed as follows: Group E1, which received 25% ethanol and a surgical cavity filled only by a blood clot, and Group E2, which received 25% ethanol and a surgical cavity filled with Gen-ox®. The animals were euthanized at 10, 20, 40 and 60 days after surgery and necropsy was performed. The histomorphological and histometric analyses of the area of connective tissue and bone neoformation showed that the reorganization of the bone marrow and full repair of the surgical cavity in Group E1 occurred more quickly than in Group E2. It was also noted that in the final period the animals in Group E2 showed areas of connective tissue and thick bone trabeculae around the particles of the implant. It can be concluded that the use of Gen-ox® delayed the process of bone repair in alcoholic rats, although it can be used as filling material because it shows osteoconductive activity, as evidenced by bone tissue formation around the graft particles.

scholarly journals Polymer-Based Instructive Scaffolds for Endodontic Regeneration

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2347 ◽  
Author(s):  
Naimah Zein ◽  
Ezeddine Harmouch ◽  
Jean-Christophe Lutz ◽  
Gabriel Fernandez De Grado ◽  
Sabine Kuchler-Bopp ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Stem Cell Differentiation ◽  
Tissue Formation ◽  
Polymer Scaffolds ◽  
Collagen Scaffolds ◽  
Pulp Tissue ◽  
Endodontic Regeneration ◽  
Clinical Conditions ◽  
Dentin Formation ◽  
Microporous Scaffolds

The challenge of endodontic regeneration is modulated by clinical conditions which determine five kinds of tissue requirements: pulp connective-tissue formation, dentin formation, revascularization, reinnervation and radicular edification. Polymer scaffolds constitute keystone of the different endodontic regenerative strategies. Indeed, scaffolds are crucial for carrying active molecules and competent cells which optimize the regeneration. Hydrogels are very beneficial for controlling viscosity and porosity of endodontic scaffolds. The nanofibrous and microporous scaffolds mimicking extracellular matrix are also of great interest for promoting dentin-pulp formation. Two main types of polymer scaffolds are highlighted: collagen and fibrin. Collagen scaffolds which are similar to native pulp tissue, are adequate for pulp connective tissue formation. Functionnalization by active biomolecules as BMP, SDF-1, G-CSF enhances their properties. Fibrin or PRF scaffolds present the advantage of promoting stem cell differentiation and concomitant revascularisation. The choice of the type of polymers (polypeptide, PCL, chitosan) can depend on its ability to deliver the active biomolecule or to build as suitable hydrogel as possible. Since 2010s, proposals to associate different types of polymers in a same scaffold have emerged for adding advantages or for offsetting a disadvantage of a polymer. Further works would study the synergetic effects of different innovative polymers composition.

Transforming Growth Factors-?1 and ?2 Enhance Connective Tissue Formation in Animal Models of Dermal Wound Healing by Secondary Intent

1990 ◽  
Vol 593 (1 Transforming) ◽  
pp. 135-147 ◽  
Author(s):  
GEORGE A. KSANDER ◽  
GEORGE H. CHU ◽  
HUGH McMULLIN ◽  
YASUSHI OGAWA ◽  
BRUCE M. PRATT ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Animal Models ◽  
Connective Tissue ◽  
Tissue Formation ◽  
Transforming Growth Factors ◽  
Dermal Wound Healing ◽  
Dermal Wound

scholarly journals The Underlying Mechanisms of Endovascular Exclusion of Intracranial Aneurysms by Coils

2003 ◽  
Vol 9 (2) ◽  
pp. 127-140 ◽  
Author(s):  
H. Henkes ◽  
S. Brew ◽  
E. Miloslavski ◽  
S. Fischer ◽  
I. Tavrovski ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Surface Properties ◽  
Intracranial Aneurysms ◽  
New Technologies ◽  
Aneurysm Rupture ◽  
Haemodynamic Effects ◽  
Tissue Formation ◽  
Limited Evidence ◽  
Spontaneous Thrombosis ◽  
Underlying Mechanisms

Endovascular coil treatment of intracranial aneurysms is now widely accepted. We discuss some of the arguments for the relative roles of electrothrombosis, spontaneous thrombosis, mechanical filling, haemodynamic effects and surface properties in successful coil treatment. Despite an enormous body of literature, with many theories and much data, there is limited evidence for, or understanding of, the mechanisms by which coil treatment protects against aneurysm rupture. It seems likely that electrothrombosis plays no part. Dense packing is probably important in preventing recurrence. New technologies aiming to encourage endothelialisation and increased connective tissue formation appear promising.

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