Correlation between MRI and Short-Term Clinical Activity in Multiple Sclerosis: Comparison between Standard- and Triple-Dose Gd-Enhanced MRI

1999 ◽  
Vol 41 (3) ◽  
pp. 123-127 ◽  
Author(s):  
M. Rovaris ◽  
M. Rodegher ◽  
G. Comi ◽  
M. Filippi
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Activity ◽  
Short Term ◽  
Enhanced Mri ◽  
Triple Dose

Short-term evolution of new multiple sclerosis lesions enhancing on standard and triple dose gadolinium-enhanced brain MRI scans

1999 ◽  
Vol 164 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Marco Rovaris ◽  
Giovanna Mastronardo ◽  
Francesca Prandini ◽  
Stefano Bastianello ◽  
Giancarlo Comi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
Short Term ◽  
Term Evolution ◽  
Mri Scans ◽  
Triple Dose

Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity

1993 ◽  
Vol 240 (2) ◽  
pp. 79-82 ◽  
Author(s):  
M. Eoli ◽  
M. Ferrarini ◽  
A. Dufour ◽  
S. Heltaj ◽  
L. Bevilacqua ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Cell Subset ◽  
Clinical Activity ◽  
Newly Diagnosed ◽  
Short Term ◽  
T Cell Subset

Short-term and long-term safety and tolerability of interferon β-1b in multiple sclerosis

2014 ◽  
Vol 3 (3) ◽  
pp. 294-302 ◽  
Author(s):  
Anthony T. Reder ◽  
Joel F. Oger ◽  
Ludwig Kappos ◽  
Paul O’Connor ◽  
Mark Rametta
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Β ◽  
Short Term

Monocyte activation in multiple sclerosis

1998 ◽  
Vol 4 (3) ◽  
pp. 162-168 ◽  
Author(s):  
Anthony T Reder ◽  
Kursad Genc ◽  
Paul V Byskosh ◽  
Anna Maria Porrini
Keyword(s):  
Multiple Sclerosis ◽  
Stable Disease ◽  
Immune Therapy ◽  
Surface Proteins ◽  
Clinical Activity ◽  
Blood Monocytes ◽  
Monocyte Activation ◽  
Cns Inflammation ◽  
Activation Markers ◽  
Peripheral Blood Monocytes

Monocytes, macrophages, and microglia have a central role in the CNS inflammation of MS. Monocytes are important in the earliest events in MS. Peripheral blood monocytes secrete prostaglandins before MS attacks. During clinical activity monocyte activation markers increase and IL-1 and TNF-a levels are elevated. Other monocyte products such as IL-10 reduce inflammation. IL-10 mRNA in MNC is increased during stable disease. Manipulation of monokine secretion and expression of monocyte surface proteins are reasonable approaches for immune therapy of MS.

Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study

2006 ◽  
Vol 12 (5) ◽  
pp. 662-665 ◽  
Author(s):  
A Charil ◽  
D Caputo ◽  
R Cavarretta ◽  
M P Sormani ◽  
P Ferrante ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Relapse Rate ◽  
Magnetization Transfer ◽  
Small Sample ◽  
Cervical Cord ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Disease Evolution ◽  
Transfer Ratio ◽  
Relapsing Remitting

Background Magnetization transfer ratio (MTR) permits the quantitative estimation of cervical cord tissue damage in patients with multiple sclerosis (MS). Objective To determine whether a single time-point MTR scan of the cervical cord is associated with short-term disease evolution in patients with relapsing-remitting (RR) MS. Methods Using a 1.5-T magnetic resonance imaging (MRI) system with a tailored cervical cord phased array coil, fast short-tau inversion recovery (fast-STIR) and MTR scans were obtained from 14 untreated patients with RRMS at baseline. Cervical cord MTR histograms were derived. Over the 18- month follow-up period, relapse rate was measured and disability assessed by the Expanded Disability Status Scale (EDSS) score. Results Average cervical cord MTR was correlated with relapse rate ( r= -0.56, P = 0.037). A moderate correlation ( r values ranging from -0.33 to -0.36) between baseline cervical cord MTR metrics and EDSS changes over 18 months was also noted, albeit statistical significance was not reached ( P = 0.26 and 0.21, respectively) perhaps because of the relatively small sample size. Conclusions This study suggests that a ‘snapshot’ MT MRI assessment of the cervical cord may detect cervical cord tissue changes associated with short-term disease evolution in RRMS.

Sign in / Sign up

Export Citation Format

Share Document