Safety and Efficacy of Cefpirome in Comparison with Ceftazidime in Chinese Patients with Sepsis due to Bacterial Infections

Chemotherapy ◽  
2000 ◽  
Vol 46 (5) ◽  
pp. 371-378 ◽  
Author(s):  
Chi-Tai Fang ◽  
Yee-Chun Chen ◽  
Seng-Fong Lin ◽  
Wen-Yi Shau ◽  
Chieh-Ju Liu ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Chinese Patients ◽  
Safety And Efficacy

scholarly journals The Safety and Efficacy of Phage Therapy for Superficial Bacterial Infections: A Systematic Review

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 754
Author(s):  
Angharad Steele ◽  
Helen J. Stacey ◽  
Steven de Soir ◽  
Joshua D. Jones
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Bacterial Infections ◽  
Chronic Wound ◽  
Phage Therapy ◽  
Data Extraction ◽  
Primary Data ◽  
Burn Wound ◽  
Promising Alternative ◽  
Safety And Efficacy

Superficial bacterial infections, such as dermatological, burn wound and chronic wound/ulcer infections, place great human and financial burdens on health systems globally and are often complicated by antibiotic resistance. Bacteriophage (phage) therapy is a promising alternative antimicrobial strategy with a 100-year history of successful application. Here, we report a systematic review of the safety and efficacy of phage therapy for the treatment of superficial bacterial infections. Three electronic databases were systematically searched for articles that reported primary data about human phage therapy for dermatological, burn wound or chronic wound/ulcer infections secondary to commonly causative bacteria. Two authors independently assessed study eligibility and performed data extraction. Of the 27 eligible reports, eight contained data on burn wound infection (n = 156), 12 on chronic wound/ulcer infection (n = 327) and 10 on dermatological infections (n = 1096). Cautionary pooled efficacy estimates from the studies that clearly reported efficacy data showed clinical resolution or improvement in 77.5% (n = 111) of burn wound infections, 86.1% (n = 310) of chronic wound/ulcer infections and 94.14% (n = 734) of dermatological infections. Over half of the reports that commented on safety (n = 8/15), all published in or after 2002, did not express safety concerns. Seven early reports (1929–1987), described adverse effects consistent with the administration of raw phage lysate and co-administered bacterial debris or broth. This review strongly suggests that the use of purified phage to treat superficial bacterial infections can be highly effective and, by various routes of administration, is safe and without adverse effects.

scholarly journals Safety and efficacy of obinutuzumab in Chinese patients with B-cell lymphomas: a secondary analysis of the GERSHWIN trial

2018 ◽  
Vol 38 (1) ◽  
pp. 31 ◽  
Author(s):  
Yan Qin ◽  
Yuqin Song ◽  
Zhixiang Shen ◽  
Xin Du ◽  
Wei Ji ◽  
...  
Keyword(s):  
B Cell ◽  
Secondary Analysis ◽  
Chinese Patients ◽  
B Cell Lymphomas ◽  
Safety And Efficacy

scholarly journals Safety and Efficacy of Atorvastatin for Chronic Subdural Hematoma in Chinese Patients

2018 ◽  
Vol 75 (11) ◽  
pp. 1338 ◽  
Author(s):  
Rongcai Jiang ◽  
Shiguang Zhao ◽  
Renzhi Wang ◽  
Hua Feng ◽  
Jianmin Zhang ◽  
...  
Keyword(s):  
Subdural Hematoma ◽  
Chronic Subdural Hematoma ◽  
Chinese Patients ◽  
Safety And Efficacy
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