Influence of Temperature and Concentration on the Postantifungal Effect and the Effects of Sub-MIC Concentrations of Four Antifungal Agents on Previously Treated Candida Species

Chemotherapy ◽  
2000 ◽  
Vol 46 (4) ◽  
pp. 245-252 ◽  
Author(s):  
M.T. García ◽  
M.T. Llorente ◽  
F. Mínguez ◽  
J. Prieto
Keyword(s):  
Antifungal Agents ◽  
Influence Of Temperature ◽  
Previously Treated ◽  
Postantifungal Effect

scholarly journals Postantifungal Effects of Echinocandin, Azole, and Polyene Antifungal Agents against Candida albicans andCryptococcus neoformans

2000 ◽  
Vol 44 (4) ◽  
pp. 1108-1111 ◽  
Author(s):  
Erika J. Ernst ◽  
Michael E. Klepser ◽  
Michael A. Pfaller
Keyword(s):  
Candida Albicans ◽  
Cryptococcus Neoformans ◽  
Amphotericin B ◽  
Antifungal Agents ◽  
Postantifungal Effect

ABSTRACT The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of Candida albicans and Cryptococcus neoformans. Concentrations ranging from 0.125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested againstC. neoformans. Fluconazole displayed no measurable PAFE against Candida albicans or Cryptococcus neoformans, either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h againstCandida spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.

Postantifungal Effect and Effects of Sub-MIC Concentrations on Previously Treated Candida sp. Influence of Growth Phase

2002 ◽  
Vol 45 (4) ◽  
pp. 263-267 ◽  
Author(s):  
M.T. Garcı́a ◽  
M.T. Llorente ◽  
F. Mı́nguez ◽  
J. Prieto
Keyword(s):  
Growth Phase ◽  
Candida Sp ◽  
Previously Treated ◽  
Postantifungal Effect

Influence of Human Serum on the Postantifungal Effect of Four Antifungal Agents on Candida albicans

Chemotherapy ◽  
1996 ◽  
Vol 42 (4) ◽  
pp. 273-279 ◽  
Author(s):  
F. Mínguez ◽  
J.E. Lima ◽  
M.T. García ◽  
J. Prieto
Keyword(s):  
Candida Albicans ◽  
Human Serum ◽  
Antifungal Agents ◽  
Postantifungal Effect

The effect of temperature on high-resolution TEM image contrast

1995 ◽  
Vol 53 ◽  
pp. 640-641
Author(s):  
T. Geipel ◽  
W. Mader ◽  
P. Pirouz
Keyword(s):  
Form Factor ◽  
Inelastic Scattering ◽  
Accurate Method ◽  
Waller Factor ◽  
Effect Of Temperature ◽  
Specimen Thickness ◽  
Influence Of Temperature ◽  
Debye Waller Factor ◽  
Influence Of Temperature On ◽  
Atomic Form Factor

Temperature affects both elastic and inelastic scattering of electrons in a crystal. The Debye-Waller factor, B, describes the influence of temperature on the elastic scattering of electrons, whereas the imaginary part of the (complex) atomic form factor, fc = fr + ifi, describes the influence of temperature on the inelastic scattering of electrons (i.e. absorption). In HRTEM simulations, two possible ways to include absorption are: (i) an approximate method in which absorption is described by a phenomenological constant, μ, i.e. fi; - μfr, with the real part of the atomic form factor, fr, obtained from Hartree-Fock calculations, (ii) a more accurate method in which the absorptive components, fi of the atomic form factor are explicitly calculated. In this contribution, the inclusion of both the Debye-Waller factor and absorption on HRTEM images of a (Oll)-oriented GaAs crystal are presented (using the EMS software.Fig. 1 shows the the amplitudes and phases of the dominant 111 beams as a function of the specimen thickness, t, for the cases when μ = 0 (i.e. no absorption, solid line) and μ = 0.1 (with absorption, dashed line).

Sign in / Sign up

Export Citation Format

Share Document