In vitro and in vivo Antibacterial Activities of S-1090, a New Oral Cephalosporin, in the Fields of Obstetrics and Gynecology

Chemotherapy ◽  
1998 ◽  
Vol 44 (3) ◽  
pp. 153-156 ◽  
Author(s):  
Hiroshige Mikamo ◽  
Kyoko Kawazoe ◽  
Yasumasa Sato ◽  
Koji Izumi ◽  
Teruhiko Tamaya
Keyword(s):  
Antibacterial Activities ◽  
Obstetrics And Gynecology ◽  
Oral Cephalosporin

In vitro and in vivo Antibacterial Activities of AM-1155 in the Fields of Obstetrics and Gynecology

Chemotherapy ◽  
1998 ◽  
Vol 44 (4) ◽  
pp. 238-242 ◽  
Author(s):  
Hiroshige Mikamo ◽  
Kyoko Kawazoe ◽  
Yasumasa Sato ◽  
Yoh Hayasaki ◽  
Koji Izumi ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Obstetrics And Gynecology

In vitro and in vivo Antibacterial Activities of a New Carbapenem BO-2727 for Use in Obstetrics and Gynecology

Chemotherapy ◽  
1997 ◽  
Vol 44 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Hiroshige Mikamo ◽  
Kyoko Kawazoe ◽  
Koji Izumi ◽  
Yasumasa Sato ◽  
Teruhiko Tamaya
Keyword(s):  
Antibacterial Activities ◽  
Obstetrics And Gynecology

scholarly journals In vitro and in vivo antibacterial activities of ME1207, a new oral cephalosporin.

1988 ◽  
Vol 32 (9) ◽  
pp. 1421-1426 ◽  
Author(s):  
A Tamura ◽  
R Okamoto ◽  
T Yoshida ◽  
H Yamamoto ◽  
S Kondo ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Oral Cephalosporin

In vitro and in vivo Antibacterial Activities of Biapenem in the Fields of Obstetrics and Gynecology

Chemotherapy ◽  
2000 ◽  
Vol 46 (2) ◽  
pp. 95-99
Author(s):  
Hiroshige Mikamo ◽  
Yasumasa Sato ◽  
Yoh Hayasaki ◽  
Teruhiko Tamaya
Keyword(s):  
Antibacterial Activities ◽  
Obstetrics And Gynecology

scholarly journals In vitro and in vivo antibacterial activities of S-1090, a new oral cephalosporin

1995 ◽  
Vol 39 (11) ◽  
pp. 2544-2551 ◽  
Author(s):  
M. Tsuji ◽  
Y. Ishii ◽  
A. Ohno ◽  
S. Miyazaki ◽  
K. Yamaguchi
Keyword(s):  
Antibacterial Activities ◽  
Oral Cephalosporin

scholarly journals In Vitro and In Vivo Antibacterial Activities of DW-224a, a New Fluoronaphthyridone

2006 ◽  
Vol 50 (6) ◽  
pp. 2261-2264 ◽  
Author(s):  
Hee-Soo Park ◽  
Hyun-Joo Kim ◽  
Min-Jung Seol ◽  
Dong-Rack Choi ◽  
Eung-Chil Choi ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
The Other ◽  
Vitro Activity ◽  
Gram Negative Bacteria ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

ABSTRACT DW-224a showed the most potent in vitro activity among the quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, DW-224a was slightly less active than the other fluoroquinolones. The in vivo activities of DW-224a against gram-positive bacteria were more potent than those of other quinolones.

scholarly journals Uncovering and Engineering a Mini-Regulatory Network of the TetR-Family Regulator SACE_0303 for Yield Improvement of Erythromycin in Saccharopolyspora erythraea

2021 ◽  
Vol 9 ◽  
Author(s):  
Ying Liu ◽  
Sabir Khan ◽  
Panpan Wu ◽  
Bowen Li ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Regulatory Network ◽  
Target Genes ◽  
Antibacterial Activities ◽  
Saccharopolyspora Erythraea ◽  
High Yield ◽  
Yield Strain ◽  
Yield Improvement ◽  
Erythromycin Production

Erythromycins produced by Saccharopolyspora erythraea have broad-spectrum antibacterial activities. Recently, several TetR-family transcriptional regulators (TFRs) were identified to control erythromycin production by multiplex control modes; however, their regulatory network remains poorly understood. In this study, we report a novel TFR, SACE_0303, positively correlated with erythromycin production in Sac. erythraea. It directly represses its adjacent gene SACE_0304 encoding a MarR-family regulator and indirectly stimulates the erythromycin biosynthetic gene eryAI and resistance gene ermE. SACE_0304 negatively regulates erythromycin biosynthesis by directly inhibiting SACE_0303 as well as eryAI and indirectly repressing ermE. Then, the SACE_0303 binding site within the SACE_0303-SACE_0304 intergenic region was defined. Through genome scanning combined with in vivo and in vitro experiments, three additional SACE_0303 target genes (SACE_2467 encoding cation-transporting ATPase, SACE_3156 encoding a large transcriptional regulator, SACE_5222 encoding α-ketoglutarate permease) were identified and proved to negatively affect erythromycin production. Finally, by coupling CRISPRi-based repression of those three targets with SACE_0304 deletion and SACE_0303 overexpression, we performed stepwise engineering of the SACE_0303-mediated mini-regulatory network in a high-yield strain, resulting in enhanced erythromycin production by 67%. In conclusion, the present study uncovered the regulatory network of a novel TFR for control of erythromycin production and provides a multiplex tactic to facilitate the engineering of industrial actinomycetes for yield improvement of antibiotics.

scholarly journals SCE-963, a New Broad-Spectrum Cephalosporin: In Vitro and In Vivo Antibacterial Activities

1978 ◽  
Vol 14 (4) ◽  
pp. 557-568 ◽  
Author(s):  
K. Tsuchiya ◽  
M. Kida ◽  
M. Kondo ◽  
H. Ono ◽  
M. Takeuchi ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Activities
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