scholarly journals Modification of Interleukin-15 Serum Levels in Workers Exposed to Chemotherapeutic Agents

2005 ◽  
Vol 2005 (1) ◽  
pp. 60-62 ◽  
Author(s):  
Giovanna Spatari ◽  
Concettina Fenga ◽  
Paola Lucia Minciullo ◽  
Giuseppe Di Pasquale ◽  
Anna Cacciola ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Serum Levels ◽  
Chemotherapeutic Agents ◽  
Care Workers ◽  
Occupationally Exposed ◽  
Interleukin 15 ◽  
Circulating Levels ◽  
Anticancer Response

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer.

scholarly journals Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers

2021 ◽  
Author(s):  
Ricardo da Silva Antunes ◽  
Suresh Pallikkuth ◽  
Erin Williams ◽  
Esther Dawen Yu ◽  
Jose Mateus ◽  
...  
Keyword(s):  
Health Care ◽  
T Cell ◽  
Health Care Workers ◽  
Cross Reactivity ◽  
Cell Reactivity ◽  
Cell Responses ◽  
Care Workers ◽  
Community Controls ◽  
T Cell Reactivity

AbstractHerein we measured CD4+ T cell responses against common cold corona (CCC) viruses and SARS-CoV-2 in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC reactive T cells in SARS-CoV-2 seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC reactivity was decreased in SARS-CoV-2 infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego.

scholarly journals Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

2021 ◽  
Author(s):  
Ricardo da Silva Antunes ◽  
Suresh Pallikkuth ◽  
Erin Williams ◽  
Dawen Yu Esther ◽  
Jose Mateus ◽  
...  
Keyword(s):  
Health Care ◽  
T Cell ◽  
Health Care Workers ◽  
Cross Reactivity ◽  
Cell Reactivity ◽  
Cell Responses ◽  
Care Workers ◽  
Community Controls ◽  
T Cell Reactivity

Abstract Herein we measured CD4 + T cell responses against common cold corona (CCC) viruses and SARS-CoV-2 in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC reactive T cells in SARS-CoV-2 seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 T cell reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC T cell reactivity was decreased in SARS-CoV-2 infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego.

Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: A multi-biomarker approach

2009 ◽  
Vol 212 (4) ◽  
pp. 414-431 ◽  
Author(s):  
Nevenka Kopjar ◽  
Verica Garaj-Vrhovac ◽  
Vilena Kašuba ◽  
Ružica Rozgaj ◽  
Snježana Ramić ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Cytotoxic Drugs ◽  
Care Workers ◽  
Occupationally Exposed

scholarly journals SERUM ANTIBODY ANALYSIS FOLLOWING HEPATITIS B VACCINATION FOR OCCUPATIONAL RISK ASSESSMENT AMONG DENTAL STUDENTS

2014 ◽  
Vol 04 (01) ◽  
pp. 052-056
Author(s):  
Shruthi Hegde ◽  
Praveen B. N. ◽  
Sumona Pal ◽  
Shishir Ram Shetty ◽  
Vidya Ajila ◽  
...  
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Health Care Workers ◽  
Booster Vaccination ◽  
Serum Levels ◽  
Dental Students ◽  
Male Gender ◽  
Smoking History ◽  
Low Responders ◽  
Care Workers

Abstract: Background & Objectives: Hepatitis B is the most important infectious occupational disease for the health care workers. Dental surgeons are frequently in contact with blood and saliva and hence are at high risk for Hepatitis B Virus (HBV) exposure. HBV infection is a major public health problem in India, as there are 45 million estimated carriers. Immunization against HBV reduces the risk of transmission of HBV to dental personnel and from dental personnel to patients. The present study was aimed to evaluate the serum levels of anti-HBs in vaccinated dental health care workers. Methods: In this study, estimation of serum levels of Anti- HBs in 40 dental students vaccinated against HBV was done. Data was obtained regarding vaccination data, age, sex, weight, height and smoking history. Anti-HBs level was evaluated two years after the 1st dose of vaccination. Low responders were given booster vaccination and post booster anti HBs assay was done. Results: The study included 110 hepatitis B vaccinated dental students. Out of 110 students only 40 students had documented history of complete vaccination and volunteered to be a part of the study. Among these 40 students, three students (7.5%) had less than 100 IU/L anti–HBs level and 37 students (92.5%) had more than 100 IU/L anti–HBs level. Anti- HBS level above 100 IU/L is identified to be protective. Following booster vaccination, low responders showed anti -HBs titre more than 100 IU/L. Conclusion: In this study majority dental students had desirable immune response to the HBV vaccine. Male gender and positive smoking history could have attributed to low anti-HBs titre in subjects who had inadequate levels in our study. Hence, all Health Care Workers, in particular dental surgeons with contributory factors like smoking habit, male gender should undergo periodic assessment of anti-HBs titre.

In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex

2003 ◽  
Vol 111 (3) ◽  
pp. 610-616 ◽  
Author(s):  
David I. Bernstein ◽  
Raymond E. Biagini ◽  
Ravi Karnani ◽  
Robert Hamilton ◽  
Karen Murphy ◽  
...  
Keyword(s):  
Health Care ◽  
Natural Rubber ◽  
Health Care Workers ◽  
Hevea Brasiliensis ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Care Workers
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