scholarly journals Complexes With Biologically Active Ligands. Part 4. Coordination Compounds of Chlorothiazide With Transition Metal Ions Behave as Strong Carbonic Anhydrase Inhibitors

1996 ◽  
Vol 3 (2) ◽  
pp. 79-83 ◽  
Author(s):  
Claudiu T. Supuran
Keyword(s):  
Transition Metal ◽  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Transition Metal Ions ◽  
Biologically Active ◽  
Carbonic Anhydrase Inhibitors

Complexes of the diuretic benzothiadiazine derivative chlorothiazide (6-chloro-7-sulfamoyl- 1,2,4-benzothiadiazine-1,1-dioxide) with V(IV); Fe(II); Co(II); Ni(II); Cu(II), Ag(I) and U(VI) were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes behave as effective inhibitors for two isozymes (I and II) of carbonic anhydrase (CA).

scholarly journals Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations

1996 ◽  
Vol 3 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Claudiu T. Supuran
Keyword(s):  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Main Group ◽  
Pharmacological Agent ◽  
Biologically Active ◽  
Modest Activity

Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA), proving modest activity towards CA II and better inhibition of CA I.

Synthesis and Hg2+ Recognition of Novel Azobenzene Derivatives Bearing Heterocyclic Units

2012 ◽  
Vol 36 (3) ◽  
pp. 146-148
Author(s):  
Yan Gao ◽  
Jian Song ◽  
Wei Wang
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Elemental Analysis ◽  
Fluorescence Spectra ◽  
Transition Metal Ions ◽  
Selective Recognition ◽  
H Nmr ◽  
Azobenzene Derivatives ◽  
C Nmr

Four novel azobenzene derivatives, 4,4'-bis(CH2SAr)azobenzene (Ar = different heterocyclic units), have been prepared and characterised by IR, 1H NMR, 13C NMR, MS and elemental analysis. Their complexation properties to different heavy and transition metal ions have been studied by UV and fluorescence spectra. The compound 4,4'-bis(4,6-dimethyl-pyrimidine-2-ylmethylthio)azobenzene shows selective recognition of Hg2+.

2-Thioxo-tetrahydro-4H-imidazol-4-ones, 2-alkylthio-3,5-dihydro-4H-imidazol-4-ones and their coordination compounds with transition metal ions

2011 ◽  
Vol 1 (4) ◽  
pp. 309-343 ◽  
Author(s):  
E. K. Beloglazkina ◽  
A. G. Majouga ◽  
E. A. Manzhelii ◽  
N. V. Zyk ◽  
N. S. Zefirov
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Transition Metal Ions

scholarly journals Complexes With Biologically Active Ligands. Part 111. Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives

1998 ◽  
Vol 5 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Andrea Scozzafava ◽  
Christine Cavazza ◽  
Claudiu T. Supuran ◽  
Ioana Saramet ◽  
Fabrizio Briganti ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Nmr Spectroscopy ◽  
Animal Models ◽  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Inhibitory Activity ◽  
Biologically Active ◽  
Standard Procedures

Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the ligands were evidenced to interact with the metal ions in the prepared complexes. The original mercaptans and their metal complexes behave as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV, but did not lower intraocular pressure in rabbits in animal models of glaucoma.

Coordination compounds in a pentacyclic aromatic system from 2-aminobenzothiazole derivatives and transition metal ions

Polyhedron ◽  
2006 ◽  
Vol 25 (12) ◽  
pp. 2363-2374 ◽  
Author(s):  
Fabiola Téllez ◽  
Adrian Peña-Hueso ◽  
Noráh Barba-Behrens ◽  
Rosalinda Contreras ◽  
Angelina Flores-Parra
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Transition Metal Ions ◽  
Aromatic System

scholarly journals Complexes With Biologically Active Ligands. Part 61 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase

1996 ◽  
Vol 3 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Joaquin Borràs ◽  
Javier Casanova ◽  
Teodora Cristea ◽  
Adriana Gheorghe ◽  
Andrea Scozzafava ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Biologically Active ◽  
Zinc Enzyme

Ternary Ni(II) complexes of hydrazine and eight heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties, were prepared and characterized by elemental analysis, spectroscopic, magnetic, thermogravimetric, and conductimetric measurements. The complexes behave as strong inhibitors for two isozymes (I and II) of carbonic anhydrase.

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