scholarly journals The Insulin-Like Growth Factor System

2003 ◽  
Vol 4 (4) ◽  
pp. 205-212 ◽  
Author(s):  
Derek Le Roith
Keyword(s):  
Growth Factor ◽  
Essential Role ◽  
Binding Proteins ◽  
The Body ◽  
Normal Adult ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Major Player ◽  
Factor System

The insulin-like growth factor (IGF) system in ubiquitous and plays a role in every tissue of the body. It is comprised of ligands, receptors and binding proteins, each with specific functions. While it plays an essential role in embryonic and post-natal development, the IGF system is also important in normal adult physiology. There are now numerous examples of diseases such as diabetes, cancer, and malnutrition in which the IGF system is a major player and, not surprisingly, there are attempts to affect these disorders by manipulating the system.

Physical capacity influences the response of insulin-like growth factor and its binding proteins to training

2002 ◽  
Vol 93 (5) ◽  
pp. 1669-1675 ◽  
Author(s):  
Lars Rosendal ◽  
Henning Langberg ◽  
Allan Flyvbjerg ◽  
Jan Frystyk ◽  
Hans Ørskov ◽  
...  
Keyword(s):  
Growth Factor ◽  
Physical Training ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Initial Training ◽  
Serum Samples ◽  
Fitness Level ◽  
Igf System ◽  
Igf I ◽  
Igfbp 3

The influence of initial training status on the response of circulating insulin-like growth factor (IGF) and its binding proteins (IGFBP) to prolonged physical training was studied in young men. It was hypothesized that highly standardized training would result in more extensive changes in the circulating IGF system in untrained subjects because of lower fitness level. Seven untrained (UT) and 12 well-trained (WT) individuals performed 11 wk of intense physical training (2–4 h daily). Fasting serum samples were analyzed for total and free IGF-I and -II, for IGFBP-1 to -4, as well as for IGFBP-3 proteolysis. Eleven weeks of physical training resulted in decreased levels of total IGF-I, free IGF-I, and IGFBP-4 in both the UT and WT groups. In the UT group, IGFBP-2 increased, IGFBP-3 decreased [from 4,255 ± 410 (baseline) to 3,896 ± 465 (SD) μg/l ( week 4); P < 0.05], and IGFBP-3 proteolysis increased [from 28 ± 8% (baseline) to 37 ± 7% ( week 4) and 39 ± 12% ( week 11); P < 0.05], whereas no significant changes were found in the WT group. In conclusion, intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals. Also, prolonged physical training resulted in increased IGFBP-3 proteolysis in previously untrained individuals only, indicating that intense physical training affects trained and untrained individuals differently.

Insulin-like growth factor-binding protein-6 and cancer

2012 ◽  
Vol 124 (4) ◽  
pp. 215-229 ◽  
Author(s):  
Leon A. Bach ◽  
Ping Fu ◽  
Zhiyong Yang
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Cancer Therapeutics ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Igf System ◽  
Binding Preference ◽  
Inhibition Of Angiogenesis ◽  
Igf Binding ◽  
Independent Effects

The IGF (insulin-like growth factor) system is essential for physiological growth and it is also implicated in a number of diseases including cancer. IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because of its marked binding preference for IGF-II over IGF-I. A principal role for IGFBP-6 is inhibition of IGF-II actions, but recent studies have indicated that IGFBP-6 also has IGF-independent effects, including inhibition of angiogenesis and promotion of cancer cell migration. The present review briefly summarizes the IGF system in physiology and disease before focusing on recent studies on the regulation and actions of IGFBP-6, and its potential roles in cancer cells. Given the widespread interest in IGF inhibition in cancer therapeutics, increasing our understanding of the mechanisms underlying the actions of the IGF ligands, receptors and binding proteins, including IGFBP-6, will enhance our ability to develop optimal treatments that can be targeted to the most appropriate patients.

scholarly journals Insulin-like Growth Factor and its Therapeutic Potential for Diabetes Complications Mechanisms and Metabolic Links: A Review

2020 ◽  
Vol 16 (1) ◽  
pp. 24-34
Author(s):  
Belete Biadgo ◽  
Workineh Tamir ◽  
Sintayehu Ambachew
Keyword(s):  
Growth Factor ◽  
Diabetes Complications ◽  
Therapeutic Potential ◽  
Alternative Therapy ◽  
Vascular Complications ◽  
The Body ◽  
Insulin Like Growth Factor ◽  
Small Blood Vessel ◽  
Igf System ◽  
And Function

BACKGROUND: The insulin-like growth factor (IGF) system is an important system in normal physiological functioning of the body. In diabetes mellitus, alterations of IGF-binding protein (IGFBP) levels have been described, mainly in vascular complications. AIM: The aim of this review was to explore the role of the IGF system in reducing diabetes complications and its role as potential therapeutic target. RESULTS: IGF-1 plays a role in neuronal growth and developmental processes. Low concentrations of IGF-1 have been associated with neuropathy and other diabetes complications. Moreover, impaired IGF synthesis and function may result in cellular senescence and impaired vascular endothelial proliferation, adhesion, and integration. Of note, high IGF-1 bioavailability may prevent or delay the inception of diabetes-associated complications in diabetes patients. The mechanism of normal functioning IGF-1 is induced by increasing nitric oxide synthesis and potassium ion channel opening in cardiovascular physiology, which improves impaired small blood vessel function and reduces the occurrence of diabetes complications associated with reduced concentrations of IGF-1. CONCLUSIONS: IGF may be considered an alternative therapy for diabetes and diabetes-associated complications. Therefore, future studies should focus on the mechanism of action and therapeutic potential of IGFs in reducing the risk of development and progression of the disease in different clinical settings.

Polycystic ovary syndrome and insulin-like growth factor (IGF) system.

2018 ◽  
Author(s):  
Ivica Lazurova ◽  
Jana Figurova ◽  
Zora Lazurova ◽  
Silvia Toporcerova ◽  
Miroslava Rabajdova ◽  
...  
Keyword(s):  
Growth Factor ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Insulin Like Growth Factor ◽  
Ovary Syndrome ◽  
Igf System

scholarly journals Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.

1992 ◽  
Vol 267 (18) ◽  
pp. 12692-12699 ◽  
Author(s):  
M.C. Kiefer ◽  
C Schmid ◽  
M Waldvogel ◽  
I Schläpfer ◽  
E Futo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Insulin ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Recombinant Human Insulin ◽  
Factor Binding
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